Review Article
Volume 12 Issue 6 - 2020
Epilepsy in Elderly Population: A Comprehensive Review
Rajib Dutta
MD Neurology, India
*Corresponding Author: Rajib Dutta, MD Neurology, India.
Received: February 13, 2020; Published: May 29, 2020




Abstract

Epilepsy is becoming recognized as a common disorder of the elderly. Within that population, it is the third most common neurological disease, after cerebrovascular disease and dementia. Clinical history and details of the event from carers or relatives is considered as the golden standard for diagnosis. Comorbidities and multiple risk factors are increasingly recognised as an important aetiological and prognostic markers. Older patients most often present with focal seizures, with less prominent auras and automatisms, and longer duration of postictal confusion. Status epilepticus is common and has a high mortality. Inspite of advances in diagnosis, many cases are either misdiagnosed or undiagnosed. Care should be taken when prescribing anticonvulsants in this age group to minimize the drug side effects. The purpose of this review is to focus on epidemiology, aetiology, diagnosis and treatment of epilepsy in elderly population.

Keywords: Elderly; Seizures; Epilepsy; Diagnosis; Anticonvulsant

References

  1. Hauser W and Hesdorffer D. “Epilepsy, Frequency, Causes and Consequences”. New York: Demos Publications (1990).
  2. Fisher RS., et al. “ILAE official report: a practical clinical definition of epilepsy”. Epilepsia 55 (2014): 475-482.
  3. Saxena S and Li S. “Defeating epilepsy: A global public health commitment”. Epilepsia Open 2 (2017): 153-155.
  4. Ding D., et al. “Primary care treatment of epilepsy with phenobarbital in rural China: cost-outcome analysis from the WHO/ILAE/IBE global campaign against epilepsy demonstration project”. Epilepsia 49 (2008): 535-539.
  5. Megiddo I., et al. “Health and economic benefits of public financing of epilepsy treatment in India: An agent-based simulation model”. Epilepsia 57 (2016): 464-474.
  6. Hauser W., et al. “Prevalence of epilepsy in Rochester, Minnesota: 1940-1980”. Epilepsia 4 (1991): 429-445.
  7. De la Court A., et al. “Prevalence of epilepsy in the elderly: the Rotterdam Study”. Epilepsia 2 (1996): 141-147.
  8. Schachter SC., et al. “An evaluation of antiepileptic drug therapy in nursing facilities”. Journal of the American Geriatrics Society 9 (1998): 1137-1141.
  9. Galimberti CA., et al. “Antiepileptic drug use and epileptic seizures in elderly nursing home residents: a survey in the province of Pavia, Northern Italy”. Epilepsy Research 1 (2006): 1-8.
  10. Garrard J., et al. “Factors associated with antiepileptic drug use among elderly nursing home residents”. The Journals of Gerontology Series A Biological Sciences 7 (2000): M384-M392.
  11. Olafsson E., et al. “Incidence of unprovoked seizures and epilepsy in Iceland and assessment of the epilepsy syndrome classification: a prospective study”. The Lancet Neurology 10 (2005): 627-634.
  12. Annegers JF., et al. “Incidence of acute symptomatic seizures in Rochester, Minnesota, 1935-1984”. Epilepsia 4 (1995): 327-333.
  13. Hauser W., et al. “Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota”. Epilepsia3 (1993): 453-468.
  14. Wallace H., et al. “Age-specific incidence and prevalence rates of treated epilepsy in an unselected population of 2, 052, 922 and age-specific fertility rates of women with epilepsy”. Lancet 352 (1998): 1970-1973.
  15. Hauser W., et al. “Seizure recurrence after a 1st unprovoked seizure: an extended follow-up”. Neurology8 (1990): 1163-1170.
  16. Berg A and Shinnar S. “The risk of seizure recurrence following a first unprovoked seizure: a quantitative review”. Neurology 7 (1991): 965-972.
  17. First Seizure Trial Group (FIR. S. T. Group). “Randomized clinical trial on the efficacy of antiepileptic drugs in reducing the risk of relapse after a first unprovoked tonic-clonic seizure”. Neurology3-1 (1993): 478-483.
  18. Hart YM., et al. “National General Practice Study of Epilepsy: recurrence after a fi rst seizure”. Lancet8726 (1990): 1271-1274.
  19. Fisher RS., et al. “Operational classification of seizure types by the International League Against Epilepsy: position paper of the ILAE Commission for classification and terminology”. Epilepsia 58 (2017): 522-530.
  20. Fisher RS., et al. “Instruction manual for the ILAE 2017 operational classification of seizure types”. Epilepsia 58 (2017): 531-542.
  21. Scheffer IE., et al. “ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology”. Epilepsia 58 (2017): 512-521.
  22. Vignatelli L., et al. “Incidence and short-term prognosis of status epilepticus in adults in Bologna, Italy”. Epilepsia7 (2003): 964-968.
  23. DeLorenzo RJ., et al. “A prospective population-based epidemiologic study of status epilepticus in Richmond Virginia”. Neurology 46 (1996): 1029-1035.
  24. Knake S., et al. “Incidence of status epilepticus in adults in Germany: a prospective, population-based study”. Epilepsia 6 (2001): 714-418.
  25. Delorenzo R. “Clinical and epidemiologic study of status epilepticus in the elderly”. In: Rowan A, Ramsay R (editions) Seizures and Epilepsy in the Elderly. Boston, MA: Butterworth-Heineman (1997): 191-205.
  26. DeLorenzo RJ., et al. “Epidemiology of status epilepticus”. Journal of Clinical Neurophysiology 4 (1995): 316-325.
  27. Lhatoo SD., et al. “Mortality in epilepsy in the first 11 to 14 years after diagnosis: multivariate analysis of a long-term, prospective, population-based cohort”. Annals of Neurology 49 (2001): 336-344.
  28. Hauser WA., et al. “Prevalence of epilepsy in Rochester Minnesota”. Epilepsia4 (1991): 429-445.
  29. Hauser W. “Epidemiology of seizures and epilepsy in the elderly”. In: Rowan A, Ramsay R (eds) Seizures and Epilepsy in the Elderly. Boston, MA: Butterworth-Heineman (1997): 7-20.
  30. Loiseau J., et al. “A survey of epileptic disorders in southwest France: seizures in elderly patients”. Annals of Neurology 3 (1990): 232-237.
  31. Stephen L and Brodie M. “Epilepsy in elderly people”. Lancet 9213 (2000): 1441-1446.
  32. Giroud M., et al. “Early seizures after acute stroke: a study of 1, 640 cases”. Epilepsia 5 (1994): 959-964.
  33. Sung C and Chu N. “Epileptic seizures in thrombotic stroke”. Journal of Neurology 3 (1990): 166-170.
  34. Bladin CF., et al. “Seizures after stroke: a prospective multicenter study”. Arch Neurology 11 (2000): 1617-1622.
  35. Lancman ME., et al. “Risk factors for developing seizures after a stroke”. Epilepsia1(1993): 141-143.
  36. Hauser W. “Seizure disorders: the changes with age”. Epilepsia 4 (1992): S6-S14.
  37. Bruns JJ and Hauser W. “The epidemiology of traumatic brain injury: a review”. Epilepsia 10 (2003): 2-10.
  38. Gilmore R. “Seizures associated with non-neurological medical conditions”. In: Wyllie E (edition) The treatment of epilepsy: principles and practice, Baltimore, MA: Williams and Wilkins (2001): 657-669.
  39. Messing R., et al. “Drug-induced seizures: a 10-year experience”. Neurology 34 (1984): 1582.
  40. Shorvon S., et al. “Antiepileptic drugs: coprescription of proconvulsant drugs and oral contraceptives: a national study of antiepileptic drug prescribing practice”. Journal of Neurology, Neurosurgery, and Psychiatry 72 (2002): 114.
  41. Kearney TE., et al. “Seizures associated with poisoning and drug overdose”. American Journal of Emergency Medicine 12 (1994): 392.
  42. Ramsay RE., et al. “Special considerations in treating the elderly patient with epilepsy”. Neurology 62 (2004): S24-S29.
  43. Luhdorf K., et al. “Etiology of seizures in the elderly”. Epilepsia 27 (1986): 458-463.
  44. Sander JW., et al. “National General Practice Study of Epilepsy: newly diagnosed epileptic seizures in a general population”. Lancet 8726 (1990): 1267-1271.
  45. Roberts M., et al. “Epileptic seizures in the elderly: I. Aetiology and type of seizure”. Age Ageing 11 (1982): 24-28.
  46. Pugh MJ., et al. “New-onset epilepsy risk factors in older veterans”. Journal of the American Geriatrics Society 57 (2009): 237-242.
  47. So EL., et al. “Population-based study of seizure disorders after cerebral infarction”. Neurology 2 (1996): 350-355.
  48. Lancman ME., et al. “Risk factors for developing seizures after a stroke”. Epilepsia 34 (1993): 141-143.
  49. Cleary P., et al. “Late-onset seizures as a predictor of subsequent stroke”. Lancet 363 (2004): 1184-1186.
  50. Ng SK., et al. “Hypertension and the risk of new-onset unprovoked seizures”. Neurology2 (1993): 425-428.
  51. Hesdorffer DC., et al. “Dementia and adult-onset unprovoked seizures”. Neurology3 (1996): 727-730.
  52. McAreavey M., et al. “Epileptic seizures in elderly patients with dementia”. Epilepsia 33 (1992): 657-660.
  53. Amatniek JC., et al. “Incidence and predictors of seizures in patients with Alzheimer’s disease”. Epilepsia 47 (2006): 867-872.
  54. Hommet C., et al. “Epilepsy and dementia in the elderly”. Dementia and Geriatric Cognitive Disorders 25 (2008): 293-300.
  55. Rao SC., et al. “Recurrent seizures in patients with dementia: frequency, seizure types, and treatment outcome”. Epilepsy and Behavior 14 (2009): 118-120.
  56. Hiyoshi T and Yagi K. “Epilepsy in the elderly”. Epilepsia9 (2004): 31-35.
  57. Annegers JF., et al. “A population-based study of seizures after traumatic brain injuries”. The New England Journal of Medicine 338 (1998): 20-24.
  58. Annegers JF., et al. “The risk of unprovoked seizures after encephalitis and meningitis”. Neurology 9 (1988): 1407-1410.
  59. Dam AM., et al. “Late-onset epilepsy: etiologies, types of seizure, and value of clinical investigation, EEG, and computerized tomography scan”. Epilepsia3 (1985): 227-231.
  60. Chadwick D and Smith D. “The misdiagnosis of epilepsy”. British Medical Journal 324 (2002): 495-496.
  61. Detoledo J. “Changing presentation of seizures with ageing: clinical and aetiological factors”. Gerontology 45 (1999): 329-335.
  62. Ramsay RE and Pryor F. “Epilepsy in the elderly”. Neurology 1 (2000): S9-S14.
  63. Xu Y., et al. “Frequency of a false positive diagnosis of epilepsy: A systematic review of observational studies”. Seizure 41 (2016): 167-174.
  64. D’Souza WJ., et al. “The use of computer-assisted-telephone-interviewing to diagnose seizures, epilepsy and idiopathic generalized epilepsy”. Epilepsy Research 1 (2010): 20-27.
  65. Duncan JS., et al. “Adult epilepsy”. Lancet 367 (2006): 1087-1100.
  66. Holmes G. “The electroencephalogram as a predictor of seizures following cerebral infarction”. Electroencephalography and Clinical 2 (1980): 83-86.
  67. Bottaro FJ., et al. “Nonconvulsive status epilepticus in the elderly: a case-control study”. Epilepsia 48 (2007): 966-972.
  68. Towne AR., et al. “Prevalence of nonconvulsive status epilepticus in comatose patients”. Neurology 54 (2000): 340-345.
  69. Beyenburg S., et al. “Acute confusion or altered mental state: consider nonconvulsive status epilepticus”. Gerontology 53 (2007): 388-396.
  70. Sheth RD., et al. “Protracted ictal confusion in elderly patients”. Arch Neurology 60 (2006): 529-532.
  71. Drury I., et al. “Value of inpatient diagnostic CCTV-EEG monitoring in the elderly”. Epilepsia 40 (1999): 1100-1102.
  72. McBride A., et al. “Video-EEG monitoring in the elderly: a review of 93 patients”. Epilepsia 2 (2002): 165-169.
  73. Hirsch LJ., et al. “Cross-sensitivity of skin rashes with antiepileptic drug use”. Neurology 71 (2008): 1527-1534.
  74. Vecht CJ and Van Breemen M. “Optimizing therapy of seizures in patients with brain tumors”. Neurology 12-4 (2006): S10-S13.
  75. Grivas A., et al. “Surgical treatment for refractory temporal lobe epilepsy in the elderly: seizure outcome and neuropsychological sequels compared with a younger cohort”. Epilepsia 47 (2006): 1364-1372.
  76. Granger A. “Ginkgo biloba precipitating epileptic seizures”. Age Ageing 30 (2001): 523-525.
  77. French JA., et al. “Efficacy and tolerability of the new antiepileptic drugs. II: treatment of refractory epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society”. Neurology 8 (2004): 1261-1273.
  78. Brodie MJ., et al. “Multicentre, double-blind, randomised comparison between lamotrigine and carbamazepine in elderly patients with newly diagnosed epilepsy”. Epilepsy Research 37 (1999): 81-87.
  79. Saetre E., et al. “LAM 40089 Study Group. An international multicenter randomised double-blind controlled trial of lamotrigine and sustained-release carbamazepine in the treatment of newly diagnosed epilepsy”. Epilepsia 48 (2007): 1292-1302.
  80. Rowan AJ., et al. “New onset geriatric epilepsy: a randomised study of gabapentin, lamotrigine and carbamazepine”. Neurology 64 (2005): 1868-1873.
  81. Garcia-Escriva A and Lopez-Hernandez N. “The use of levetiracetam in monotherapy in post stroke seizures in the elderly population”. Revista de Neurología 45 (2007): 523-525.
  82. Alsaadi TM., et al. “Levetiracetam monotherapy for elderly patients with epilepsy”. Seizure 13 (2004): 58-60.
  83. Ferrendelli JA., et al. “Use of levetiracetam in a population of patients aged 65 years and older: a subset analysis of the KEEPER trial”. Epilepsy and Behavior 4 (2003): 702-709.
  84. Morrell MJ., et al. “The KEEPER(TM) trial: levetiracetam adjunctive treatment of partial-onset seizures in an open-label community-based study”. Epilepsy Research 43 (2003): 153-161.
  85. Kutluay E., et al. “Safety and tolerability of oxcarbazepine in elderly patients with epilepsy”. Epilepsy and Behavior 4 (2003): 175-180.
  86. Ramsay RE., et al. “Topiramate in older patients with partial-onset seizures: a pilot double-blind, dose-comparison study”. Epilepsia 49 (2008): 1180 -1185.
  87. Read CL., et al. “Cognitive effects of anticonvulsant monotherapy in elderly patients: a placebo-controlled study”. Seizure 7 (1998): 159-162.
  88. Cameron H and Macphee G. “Anticonvulsant therapy in the elderly -a need for placebo controlled trials”. Epilepsy Research 21 (1995): 149-157.
  89. Leppik IE and Birnbaum AK. “Epilepsy in the elderly”. Seminars in Neurology 22 (2002): 309-320.
  90. Cleary P., et al. “Late onset seizures as a predictor of subsequent stroke”. Lancet 363 (2004): 1184-1186.
  91. Chang B and Lowenstein D. “Practice parameter: antiepileptic drug prophylaxis in severe traumatic brain injury: report of the Quality Standards Subcommittee of the American Academy of Neurology”. Neurology 60 (2003): 10-16.
  92. Glantz MJ., et al. “Practice parameter: anticonvulsant prophylaxis in patients with newly diagnosed brain tumours: report of the Quality Standards Subcommittee of the American Academy of Neurology”. Neurology 54 (2000): 1886-1893.
  93. Rudà R., et al. “Epilepsy in brain metastasis: an emerging entity”. Current Treatment Options in Neurology 2 (2020): 6.
  94. Haut SR., et al. “Seizures in the elderly: impact on mental status, mood and sleep”. Epilepsy and Behavior 14 (2009): 540-544.
  95. Ranta A and Wooten G. “Hyponatraemia due to an additive effect of carbamazepine and thiazide diuretics”. Epilepsia 45 (2004): 879.
  96. Dong X., et al. “Hyponatraemia from oxcarbazepine and carbamazepine”. Neurology 65 (2005): 1976-1978.
  97. Acosta I., et al. “Epilepsy surgery after age 60”. Epilepsy and Behavior 2 (2008): 324-325.
  98. McLachlan RS., et al. “Temporal lobectomy for intractable epilepsy in patients over age 45 years”. Neurology3-1 (1992): 662-665.
  99. Sirven JI., et al. “Temporal lobectomy in older versus younger adults”. Neurology 54 (2000): 2166-2170.
  100. Boling W., et al. “Surgery for temporal lobe epilepsy in older patients”. Journal of Neurosurgery 95 (2001): 242-248.
  101. Grivas A., et al. “Surgical treatment for refractory temporal lobe epilepsy in the elderly: Seizure outcome and neuropsychological sequels compared with a younger cohort”. Epilepsia 47 (2006): 1364-1372.
  102. Tellez-Zenteno JF., et al. “Epilepsy surgery in the elderly: An unusual case of a 75 year old man with recurrent status epilepticus”. Epileptic Disorders 11 (2009): 144-149.
  103. Srikijvilaikul T., et al. “Outcome of temporal lobectomy for hippocampal sclerosis in older patients”. Seizure 20 (2011): 276-279.
  104. Nissen-Meyers LS., et al. “Levetiracetam, phenytoin, and differently on rat bone mass, structure and metabolism”. Epilepsia 48 (2007): 1850-1860.
  105. Sheth RD and Hermann BP. “Bone mineral density with lamotrigine monotherapy for epilepsy”. Pediatric Neurology 37 (2007): 250-254.
  106. Ensrud KE., et al. “Osteoporotic Fractures in Men (MrOS) Study Research Group. Antiepileptic drug use and rates of hip bone loss in older men: A prospective study”. Neurology 71 (2008): 723-730.
  107. Lin PT., et al. “Social functioning and health-related quality of life trajectories in people with epilepsy after epilepsy surgery”. Epilepsy and Behavior 103 (2020): 106849.
  108. Billakota S., et al. “Why we urgently need improved epilepsy therapies for adult patients”. Neuropharmacology (2019): 107855.
  109. Labar D., et al. “Non-convulsive status epilepticus in the elderly: A case series and review of the literature”. Journal of Epilepsy 11 (1998): 74-78.
  110. Manfredonia F., et al. “Prevalence and clinical correlates of non-convulsive status epilepticus in elderly patients with acute confusional state: A systematic literature review”. Journal of the Neurological Sciences 410 (2020): 116674.
  111. Leitinger M., et al. “Epidemiology of status epilepticus in adults: Apples, pears, and oranges - A critical review”. Epilepsy and Behavior 103 (2020): 106720.
  112. Fernandez H., et al. “Epilepsy and lifestyle behaviors related to bone health”. Epilepsia11 (2019): 2306-2313.
  113. Shaikh AS., et al. “The Impact of Antiepileptic Drugs on Vitamin Levels in Epileptic Patients”. Current Pharmaceutical Biotechnology 8 (2018): 674-681.
  114. Hernandez AR., et al. “Age and Ketogenic Diet Have Dissociable Effects on Synapse-Related Gene Expression Between Hippocampal Subregions”. Frontiers in Aging Neuroscience 11 (2019): 239.
  115. Martin-McGill KJ., et al. “The modified ketogenic diet for adults with refractory epilepsy: An evaluation of a set up service”. Seizure 52 (2017): 1-6.
  116. Kwon CS., et al. “Epilepsy and neuromodulation - randomized controlled trials”. Behavioral and Brain Sciences 8 (2018): 69.
  117. Boon P., et al. “Neurostimulation for drug-resistant epilepsy: a systematic review of clinical evidence for efficacy, safety, contraindications and predictors for response”. Current Opinion in Neurology 31 (2018): 198-210.
  118. Ryvlin P., et al. “The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial”. Epilepsia 55 (2014): 893-900.
  119. Olivié L., et al. “External trigeminal nerve stimulation: A long term follow up study”. Seizure 69 (2019): 218-220.
  120. Young, MG., et al. “Using electrocorticogram baseline seizure frequency to assess the efficacy of responsive neurostimulation”. Epilepsy and Behavior 85 (2018): 7-9.
  121. Skarpaas TL., et al. “Clinical and electrocorticographic response to antiepileptic drugs in patients treated with responsive stimulation”. Epilepsy and Behavior 83 (2018): 192-200.
  122. Révész D., et al. “Estimating Long-Term Vagus Nerve Stimulation Effectiveness: Accounting for Antiepileptic Drug Treatment Changes”. Neuromodulation8 (2018): 797-804.
  123. Elger CE and Hoppe C. “Diagnostic challenges in epilepsy: seizure underreporting and seizure detection”. The Lancet Neurology 17 (2018): 279-288.
  124. Van der Lende M., et al. “Value of video monitoring for nocturnal seizure detection in a residential setting”. Epilepsia 57 (2016): 1748-1753.
  125. Van Andel J., et al. “Non-EEG based ambulatory seizure detection designed for home use: what is available and how will it influence epilepsy care?” Epilepsy and Behavior 57 (2016): 82-89.
  126. Hoppe C., et al. “Epilepsy: accuracy of patient seizure counts”. Arch Neurology 64 (2007): 1595-1599.
  127. Jain P., et al. “Systematic review and network meta-analysis of resective surgery for mesial temporal lobe epilepsy”. Journal of Neurology, Neurosurgery, and Psychiatry 11 (2018): 1138-1144.
  128. Cloppenborg T., et al. “Trends in epilepsy surgery: stable surgical numbers despite increasing presurgical volumes”. Journal of Neurology, Neurosurgery, and Psychiatry 87 (2016): 1322-1329.
  129. Boon P., et al. “A prospective, multicenter study of cardiac-based seizure detection to activate vagus nerve stimulation”. Seizure 32 (2015): 52-61.
  130. Salanova V., et al. “SANTE Study Group. Long-term efficacy and safety of thalamic stimulation for drug-resistant partial epilepsy”. Neurology 84 (2015): 1017-1025.
  131. Bergey GK., et al. “Long-term treatment with responsive brain stimulation in adults with refractory partialseizures”. Neurology 84 (2015): 810-817.
  132. Elger CE and Hoppe C. “Diagnostic challenges in epilepsy: seizure underreporting and seizure detection”. Lancet Neurology 17 (2018): 279-288.
Citation: Rajib Dutta. “Epilepsy in Elderly Population: A Comprehensive Review”. EC Neurology 12.6 (2020): 61-71.

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We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the August issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for September Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the September issue of respective journals. Submissions are accepted on/before August 21, 2020.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk