Research Article
Volume 12 Issue 4 - 2020
A Pilot Study of Photobiomodulation Therapy Using Nir: Pre and Post 810 Nm Stimulation in Patients Affected by Neurological Diseases
Samorindo Peci1*, Giovanni Giannelli2, Rosjana Pica3, Giuseppina Salvo3, Katarina Ivic4 and Federica Peci3
1Ce.Ri.Fo.S, Milan, Italy
2Public Department “Centro Demenze e Disturbi Cognitivi”, Cesena, Italy
3M.S, Cerebro, Milan, Italy
4M.A, Cerebro, Milan, Italy
*Corresponding Author: Samorindo Peci, Ce.Ri.Fo.S, Milan, Italy.
Received: March 03, 2020; Published: March 31, 2020




Abstract

Photobiomodulation is known to become a very important tool in treatment and support of neurological disease. The cellular processes involved during Red and Infrared Light Stimulation allows alleviating and improving cognitive and motor functions. The aim of this article is to highlight the use of NIR by Cerebro® in patients with neurological disease and to assess, as it is a pilot study, the perceived improvements in everyday life. 29 Italian patients underwent NIR stimulation therapy for 1-month and were tested before and after this stimulation period in order to assess whether there will be a difference in their perception of cognitive failures that occur in everyday life based on the Cognitive Self-Assessment Questionnaire. Although the sample is small, the data collected show that there is an improvement in the perceived quality of life in each pathological group taken into account. This allows us to carry on research in this field trying to understand and improve the role of NIR during physical and neurological rehabilitation.

Keywords: NIR; Photobiomodulation; Neurological Disease; Cerebro®; Stimulation Therapy

References

  1. Heiskanen Vladimir and Michael R Hamblin. “Photobiomodulation: Lasers vs. Light Emitting Diodes?” Photochemical and Photobiological Sciences (2018).
  2. Mester Andrew and Adam Mester. “The history of photobiomodulation: Endre Mester (1903-1984)”. (2017): 393-394.
  3. Sharma Sulbha K., et al. "Dose response effects of 810 nm laser light on mouse primary cortical neurons”. Lasers in Surgery and Medicine8 (2011): 851-859.
  4. Ilic Sanja., et al. "Effects of power densities, continuous and pulse frequencies, and number of sessions of low-level laser therapy on intact rat brain”. Photomedicine and Laser Therapy 4 (2006): 458-466.
  5. Huang Ying-Ying., et al. "Biphasic dose response in low level light therapy”. Dose-response 4 (2009).
  6. Yip KK., et al. "The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia”. Neuroscience 190 (2011): 301-306.
  7. Abid Oueslati Blaise Lovisa, et al. "Photobiomodulation suppresses alpha-synuclein-induced toxicity in an AAV-based rat genetic model of Parkinson’s disease”. PloS one10 (2015).
  8. Ando Takahiro., et al. "Comparison of therapeutic effects between pulsed and continuous wave 810-nm wavelength laser irradiation for traumatic brain injury in mice”. PloS one10 (2011).
  9. De Taboada Luis., et al. "Transcranial laser therapy attenuates amyloid-β peptide neuropathology in amyloid-β protein precursor transgenic mice”. Journal of Alzheimer's Disease3 (2011): 521-535.
  10. Schiffer F., et al. “Psychological benefits 2 and 4 weeks after a single treatment with near infrared light to the forehead: a pilot study of 10 patients with major depression and anxiety”. Behavioral and Brain Functions 1 (2009): 46.
  11. Salehpour Farzad and Seyed Hossein Rasta. "The potential of transcranial photobiomodulation therapy for treatment of major depressive disorder”. Reviews in the Neurosciences 4 (2017): 441-453.
  12. Santana-Blank Luis., et al. “Quantum leap” in photobiomodulation therapy ushers in a new generation of light-based treatments for cancer and other complex diseases: perspective and mini-review”. Photomedicine and Laser Surgery 3 (2016): 93-101.
  13. Chen Yongmei, et al. “Thermal Effects of Transcranial near-Infrared Laser Irradiation on Rabbit Cortex”. Neuroscience Letters 553 (2013): 99-103.
  14. Purushothuman Sivaraman., et al. “Photobiomodulation with near Infrared Light Mitigates Alzheimer’s Disease-Related Pathology in Cerebral Cortex - Evidence from Two Transgenic Mouse Models”. Alzheimers Research and Therapy 1 (2014): 2.
  15. Quirk Brendan J., et al. “Near-Infrared Photobiomodulation in an Animal Model of Traumatic Brain Injury: Improvements at the Behavioral and Biochemical Levels”. Photomedicine and Laser Surgery9 (2012): 523-529.
  16. Liang Hl., et al. “Photobiomodulation Partially Rescues Visual Cortical Neurons from Cyanide-Induced Apoptosis”. Neuroscience 2 (2006): 639-649.
  17. Lee Hae In., et al. “Pre-Conditioning with Transcranial Low-Level Light Therapy Reduces Neuroinflammation and Protects Blood-Brain Barrier after Focal Cerebral Ischemia in Mice”. Restorative Neurology and Neuroscience2 (2016): 201-214.
  18. Moreira Maria Stella., et al. "Effect of phototherapy with low intensity laser on local and systemic immunomodulation following focal brain damage in rat”. Journal of Photochemistry and Photobiology B: Biology 3 (2009): 145-151.
  19. Yan Xiaodong., et al. "Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway”. Lasers in Medical Science1 (2017): 169-180.
  20. Xuan Weijun., et al. "Repeated transcranial low‐level laser therapy for traumatic brain injury in mice: biphasic dose response and long‐term treatment outcome”. Journal of Biophotonics 11-12 (2016): 1263-1272.
  21. Xu Zhiqiang., et al. "Low-level laser irradiation improves depression-like behaviors in mice”. Molecular Neurobiology 6 (2017): 4551-4559.
  22. Naeser Margaret A., et al. "Significant improvements in cognitive performance post-transcranial, red/near-infrared light-emitting diode treatments in chronic, mild traumatic brain injury: open-protocol study”. Journal of Neurotrauma11 (2014): 1008-1017.
  23. Lapchak Paul A. “Taking a Light Approach to Treating Acute Ischemic Stroke Patients: Transcranial near-Infrared Laser Therapy Translational Science”. Annals of Medicine 8 (2010): 576-586.
  24. Henderson Theodore A and Larry Morries. “Near-Infrared Photonic Energy Penetration: Can Infrared Phototherapy Effectively Reach the Human Brain?” Neuropsychiatric Disease and Treatment (2015): 2191.
  25. Freitas Lucas Freitas De and Michael R Hamblin. “Proposed Mechanisms of Photobiomodulation or Low-Level Light Therapy”. IEEE Journal of Selected Topics in Quantum Electronics 3 (2016): 348-364.,
  26. Hamblin Michael R and Tatiana N Demidova. “Mechanisms of Low Level Light Therapy”. Mechanisms for Low-Light Therapy (2006).
  27. Huang Ying‐Ying., et al. "Low‐level laser therapy (LLLT) reduces oxidative stress in primary cortical neurons In vitro”. Journal of Biophotonics 10 (2013): 829-838.
  28. Naeser Margaret A., et al. "Improved cognitive function after transcranial, light-emitting diode treatments in chronic, traumatic brain injury: two case reports”. Photomedicine and Laser Surgery5 (2011): 351-358.
  29. Karu TI. "Molecular mechanism of the therapeutic effect of low-intensity laser radiation”. Lasers Life Sciences1 (1988): 53-74.
  30. Cooper CE., et al. “Use of Mitochondrial Inhibitors to Demonstrate That Cytochrome Oxidase Near-Infrared Spectroscopy Can Measure Mitochondrial Dysfunction Noninvasively in the Brain”. British Journal of Pharmacology 19 (1999): 27-38.
  31. Hamblin Michael R. "Photobiomodulation for Alzheimer’s Disease: Has the Light Dawned?”. Photonics. Vol. 6. No. 3. Multidisciplinary Digital Publishing Institute (2019).
  32. Hennessy Hamblin. “Photobiomodulation of the Brain: a New Paradigm (Conference Presentation)”. Mechanisms of Photobiomodulation Therapy XII (2017).
  33. Lane Nick. "Cell biology: power games” (2006): 901.
  34. Waypa Gregory B., et al. "O2 sensing, mitochondria and ROS signaling: the fog is lifting”. Molecular Aspects of Medicine 47 (2016): 76-89.
  35. Zhao Yingzi., et al. "Vascular nitric oxide: Beyond eNOS”. Journal of Pharmacological Sciences2 (2015): 83-94.
  36. Filiano Anthony J., et al. "Interactions of innate and adaptive immunity in brain development and function”. Brain Research 1617 (2015): 18-27.
  37. Hamblin Michael R. "Shining light on the head: photobiomodulation for brain disorders”. BBA Clinical 6 (2016): 113-124.
  38. Saltmarche Anita E., et al. "Significant improvement in cognition in mild to moderately severe dementia cases treated with transcranial plus intranasal photobiomodulation: case series report”. Photomedicine and Laser Surgery8 (2017): 432-441.
  39. Berman Marvin H., et al. "Photobiomodulation with near infrared light helmet in a pilot, placebo controlled clinical trial in dementia patients testing memory and cognition”. Journal of neurology and Neuroscience1 (2017).
  40. Oron Amir., et al. "Low-level laser therapy applied transcranially to rats after induction of stroke significantly reduces long-term neurological deficits”. Stroke 10 (2006): 2620-2624.
  41. Yun Yeong-Chan., et al. "Laser acupuncture exerts neuroprotective effects via regulation of Creb, Bdnf, Bcl-2, and Bax gene expressions in the hippocampus”. Evidence-Based Complementary and Alternative Medicine 2017 (2017).
  42. Moro Cécile., et al. "Photobiomodulation inside the brain: a novel method of applying near-infrared light intracranially and its impact on dopaminergic cell survival in MPTP-treated mice”. Journal of Neurosurgery3 (2014): 670-683.
  43. Maloney Ryan., et al. "The application of low-level laser therapy for the symptomatic care of late stage Parkinson's Disease: a non-controlled, non-randomized study: # 185”. Lasers in Surgery and Medicine 42 (2010).
  44. Naeser M., et al. "Improved language after scalp application of red/near-infrared light-emitting diodes: pilot study supporting a new, noninvasive treatment for chronic aphasia”. Procedia-Social and Behavioral Sciences 61 (2012): 138-139.
  45. Ab Boonswang N., et al. "A new treatment protocol using photobiomodulation and muscle/bone/joint recovery techniques having a dramatic effect on a stroke patient's recovery: a new weapon for clinicians”. Case Reports (2012): bcr0820114689.
Citation: Samorindo Peci., et al. “A Pilot Study of Photobiomodulation Therapy Using Nir: Pre and Post 810 Nm Stimulation in Patients Affected by Neurological Diseases”. EC Neurology 12.4 (2020): 103-118.

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