Short Communication
Volume 12 Issue 5 - 2020
The Star Studded Protein and its Chaperone Mediated Pathways: Faulty Lysosomal-Autophagic System, Alpha-Synuclein Aggregates in Parkinson’s Disease and its Relevance to Therapeutic Intervention
Jeswinder Sian-Hulsmann*
Department of Medical Physiology, University of Nairobi, Kenya
*Corresponding Author: Jeswinder Sian-Hulsmann, Department of Medical Physiology, University of Nairobi, Kenya.
Received: March 05, 2020; Published: April 30, 2020

Plethora of research findings over recent years have led to the elevation of α-synuclein to star status in the etiology of PD. Rogue pathogenic proteins such as α-synuclein, appear to play a malevolent role in the development of Parkinson’s disease(PD) and other α-synucleinopathies. They share a common denominator, which is characterised by aggregates of misfolded α-synuclein, which results in the formation of intra-neuronal inclusions known as Lewy bodies (LB). The presence of LB in substantia nigra is mandatory for the neuropathological diagnosis of PD. Interestingly, the occurrence of these structures appear to mirror areas exhibiting neuronal cell loss such as the substantia nigra pars compacta and other brain areas burdened with the onslaught of the disease, thereby suggesting that they are of focal relevance to the disorder. Furthermore, the presence of LB in the asymptomatic phase of PD (incidental Lewy body disease; [1] endorses their role in the pathogenesis. It is unclear whether they represent a cause or consequence of the illness. Therefore, in order to advocate effective therapeutic intervention it is imperative to elucidate the pathways or mechanism(s) underlying disruption of protein homeostasis, α-synuclein accumulation LB formation.


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Citation: Jeswinder Sian-Hulsmann. “The Star Studded Protein and its Chaperone Mediated Pathways: Faulty Lysosomal-Autophagic System, Alpha-Synuclein Aggregates in Parkinson’s Disease and its Relevance to Therapeutic Intervention”. EC Neurology 12.5 (2020): 46-49.

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