Research Article
Volume 12 Issue 4 - 2020
Combined Bio-Impedance and Transcranial Doppler Ultrasonography in Parkinson’s Patients and Neurologically Normal Ageing Subjects
Vardy TC1*, Moskalenko Yu2, Mokhov3 and R Todd Dombroski4
1Queensland University of Technology, Brisbane, Australia
2Osteopathy Department, Mechnikov North-West State Medical University, Saint Petersburg, Russia
3Institute of Osteopathy, St. Petersburg State University, Saint Petersburg, Russia 4Department of Mechanical Engineering, University of North Texas, Denton, Texas, United States of America
*Corresponding Author: Vardy TC, Queensland University of Technology, Brisbane, Australia.
Received: February 10, 2020; Published: March 03, 2020


Objective: Current knowledge of intracranial fluid dynamics in Parkinson’s disease patients is limited. Magnetic Resonance Imaging, computerized tomography and Positron Emission Tomography provide important information of cranial fluid changes but are static. 

Materials and Methods: 20 Parkinson patients, stage I-III Hoehn and Yahr and 22 age and gender matched neurologically normal subjects were enrolled in a prospective 2 year study. Monitoring consisted of transcranial Doppler, bio-impedance, near infrared, Portapres®, electrocardiogram, chest respiratory band, and galvanic skin response. Transcranial Doppler measured blood flow into each brain hemisphere and the and bioimpedance device measured the volumes of cerebrospinal fluid (CSF) within the cranium. Perturbations were orthostatic and cognitive challenges. 

Results: Parkinson patients utilized their right brain hemisphere in contrast to neurologically normal ageing subjects (left hemisphere was dominant) pre and post all cognitive and orthostatic tests, p = 0.0039.

Significantly increased diastolic volume of cerebrospinal fluid was measured in the neurologically normal subjects left hemispheres pre and post all orthostatic and cognitive tests compared to the PD patients, p = 0.0275. 

Conclusion: The left-brain hemisphere is normally associated with analytical reasoning, mathematical calculations and logic and all neurologically normal subjects. In contrast, all Parkinson subjects used their right brain hemispheres for solving the arithmetic cognitive tests.

Keywords: Cranium; Brain; Blood; Cerebrospinal Fluid (CSF); Bio-Impedance; Parkinson’s Disease; Ageing; Doppler; Cognition


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Citation: Vardy TC., et al. “Combined Bio-Impedance and Transcranial Doppler Ultrasonography in Parkinson’s Patients and Neurologically Normal Ageing Subjects”. EC Neurology 12.4 (2020): 04-12.

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