Research Article
Volume 12 Issue 4 - 2020
The Decreased Serum Level of Vitamin D3 is Correlated with Impaired Sleep and Cognition in Patients with Chronic Insomnia Disorder
Ting-Ting Qian, Ying-Xue Li, Yi-Jun Ge, Ping Zhang, Xue-Yan Li, Xiao-Yi Kong and Gui-Hai Chen*
Department of Neurology (Sleep Disorders), The Affiliated Chaohu Hospital of Anhui Medical University, Hefei (Chaohu), China
*Corresponding Author: Gui-Hai Chen, Department of Sleep Disorders, The Affiliated Chaohu Hospital of Anhui Medical University, Hefei (Chaohu), China.
Received: February 17, 2020; Published: March 27, 2020




Abstract

Objectives: To explore serum level of 25-hydroxy vitamin D3 [25(OH)D3] and its correlations with sleep quality and cognitive function in the patients with chronic insomnia disorder (CID). 

Methods: Fifty CID patients and forty healthy controls were enrolled. Pittsburgh Sleep Quality Index (PSQI), Montreal Cognitive Assessment scale (MoCA) and Nine-Box Maze Test were used to assess insomnia severity, general cognitive function and the special memories, including object/spatial reference memories,object/spatial working memories and object recognition memory, with the objective sleep status being assessed using polysomnography overnight in 26 patients. The serum level of 25(OH)D3 was detected using ELISA. 

Results: Compared to the controls, the CID patients had significantly higher PSQI score (P < 0.001) and lower MoCA score (P < 0.001). The CID patients had significantly more errors in object working (Z = -2.304, P = 0.021), spatial working (Z = -4.927, P < 0.001) and object recognition memories (Z = -3.770, P < 0.001) in Nine-Box Maze Test than the controls, with lower serum level of 25(OH)D3 (P < 0.001). The partial correlation analysis showed that in the CID patients, the level of 25(OH)D3 correlated negatively with PSQI score (r = -0.320, P = 0.030), number of errors in spatial working memory (r = -0.300, P = 0.043) and duration of illness (r = -0.360, P = 0.014), and positively with total sleep time (r = 0.515, P = 0.014) and MoCA score (r = 0.422, P = 0.003). 

Conclusion: The level of 25(OH)D3 decreased in the CID patients, which was correlated with insomnia severity and illness duration, and might affect the general cognitive function and spatial working memory.

Keywords: Cognition; Insomnia; Polysomnography; Serum; Vitamin D

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Citation: Gui-Hai Chen., et al. “The Decreased Serum Level of Vitamin D3 is Correlated with Impaired Sleep and Cognition in Patients with Chronic Insomnia Disorder”. EC Neurology 12.4 (2020): 91-100.

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