Review Article
Volume 12 Issue 3 - 2020
Brain Network and Homeostatic Influences in Epileptogenic Spreading
Denis Larrivee1,2*
1Loyola University Chicago, USA
2University of Navarra Medical School, Pamplona, Spain
*Corresponding Author: Denis Larrivee, Loyola University Chicago, USA and University of Navarra Medical School, Pamplona, Spain.
Received: January 27, 2020; Published: February 07, 2020


After stroke, epilepsy is the second leading brain impairment, affecting over 50 million people worldwide. Its persistent seizures often cause various sequelae such as momentary deviations in perception and behavior, mild convulsions, and temporary loss of consciousness, which are due to the spread of epileptogenesis to various brain regions. Among the multifactorial influences contributing to the variation in the spread of seizure foci are particular domains affected, mechanisms of spatial distribution, and the nature of the disturbance eliciting seizure foci. Unlike the influence of homeostatic perturbations, these latter are likely to involve operational and global structures of cognition, that is, top down as opposed to bottom up influences that affect seizure distribution in complex ways. Current studies suggest that these mechanisms could entail the interaction of both ictal and extra-ictal electrical events with global oscillatory activity that mediates higher order cognitive events.

Keywords: Brain; Homeostatic; Epileptogenic; Consciousness Disorders; Temporal Lobe epilepsy; Global Workspace Model; General Epilepsy


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Citation: Denis Larrivee.“Brain Network and Homeostatic Influences in Epileptogenic Spreading”. EC Neurology 12.3 (2020): 01-09.

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