Review Article
Volume 18 Issue 8 - 2022
Overview of Lymphadenopathy Causes and Diagnosis
Baraa Faiez Rajab1*, Doaa Izzeldin Elsheikh Abdalla2, Mustafa Mohammed Fadlalla Mohammed3, Abdulaziz Jaber Alamri4, Abdullah Nabil Attar1, Mohammed Ahmed Alghamdi5, Tarik Abdulrahman Hobani6, Mutaz Abdalhakam Abdalazez Taha7, Khalid Abdulaziz Balbaid8, Saleh Ghormallah Alghamdi9, Emad Ahmed Ezzalddin1, Lojein Faisal Ahmed Alnomari10 and Wid Ameer Nawab6
1King Abdulaziz Hospital, Jeddah, Saudi Arabia
2Renew Clinics, Jeddah, Saudi Arabia
3King Saud Medical City, Riyadh, Saudi Arabia
4Umm Al Qura University, Makkah, Saudi Arabia
5Al-Baha Univeristy, Al-Baha, Saudi Arabia
6East Jeddah General Hospital, Jeddah, Saudi Arabia
7Derriford Hospital, Plymouth, England, UK
8Dhurma General Hospital, Dhurma, Saudi Arabia
9King Abdulaziz University, Jeddah, Saudi Arabia
10Ibn Sina National College Collage, Jeddah, Saudi Arabia
*Corresponding Author: Baraa Faiez Rajab, Consultant General Medicine, King Abdulaziz Hospital, Jeddah, Saudi Arabia.
Received: July 02, 2022; Published: July 28, 2022


Introduction: A wide variety of diseases can manifest as lymphadenopathy or swollen lymph nodes. When encountering a case of lymphadenopathy, certain diagnostic considerations include the age of the individual person, location of the pathology, duration of illness, and any associated symptoms. The critical task is to differentiate between benign, malignant, and any other condition requiring specific management. The differentiation is based on clinical, radiological, and histological investigations.

Aim of Work: The aim of this study is to overview lymphadenopathy.

Materials and Methods: This review is a comprehensive search of PUBMED from the year 1974 to 2021.

Conclusion: Since lymph nodes behave like the police stations of our body, lymphadenopathy involves a wide range of diseases. Several considerations influence both the incidence and prognosis of lymphadenopathy. In general, lymphadenopathy occurs more commonly among children and in the cervical region. The size and shapes of lymph nodes on radiographic imaging can suggest possible disease-causing lymphadenopathy. Further diagnostic evaluation, if needed, is done by FNAC, but excisional biopsy is considered the gold standard. A plethora of investigations comprising of history taking, physical exam, imaging, lab work, and finally, a biopsy may decide the possible treatment plan.

Keywords: Lymphadenopathy; Lymph Node; Ultrasound; Computed Tomography; FNAC; Biopsy; Malignancy


  1. Zeppa P and Cozzolino I. “Lymphadenitis and lymphadenopathy”. Lymph Node FNC 23 (2018): 19-33.
  2. Maini R and Nagalli S. “Lymphadenopathy”. In StatPearls [Internet]. StatPearls Publishing (2021).
  3. Aspelund A., et al. “Lymphatic system in cardiovascular medicine”. Circulation Research3 (2016): 515-530.
  4. Gowing NFC. “Tumours of the lymphoreticular system: nomenclature, histogenesis, and behaviour”. Journal of Clinical Pathology 7 (1974): 103.
  5. Habermann TM and Steensma DP. “Lymphadenopathy”. In Mayo Clinic Proceedings7 (2000): 723-732.
  6. Leung AK and Robson WLM. “Childhood cervical lymphadenopathy”. Journal of Pediatric Health Care1 (2004): 3-7.
  7. Lee YTN., et al. “Lymph node biopsy for diagnosis: a statistical study”. Journal of Surgical Oncology1 (1980): 53-60.
  8. Ganeshalingam S and Koh DM. “Nodal staging”. Cancer Imaging1 (2009): 104.
  9. Ferrer R. “Lymphadenopathy: differential diagnosis and evaluation”. American Family Physician6 (1998): 1313.
  10. Moor JW., et al. “Diagnostic biopsy of lymph nodes of the neck, axilla and groin: rhyme, reason or chance?” The Annals of The Royal College of Surgeons of England3 (2008): 221-225.
  11. Fijten GH and Blijham GH. “Unexplained lymphadenopathy in family practice”. The Journal of Family Practice 27 (1988): 373-376.
  12. Ahuja AT and Ying M. “Sonographic evaluation of cervical lymph nodes”. American Journal of Roentgenology5 (2005): 1691-1699.
  13. Mao Y., et al. “Radiologic assessment of lymph nodes in oncologic patients”. Current Radiology Reports2 (2014): 1-13.
  14. Fecher RA., et al. “Tonsillar small cell carcinoma: potential contribution of human papillomavirus”. The American Journal of Case Reports 19 (2018): 482.
  15. Hafez NH and Tahoun NS. “Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy”. Journal of the Egyptian National Cancer Institute3 (2011): 105-114.
  16. Özkan EA., et al. “Evaluation of peripheral lymphadenopathy with excisional biopsy: six-year experience”. International Journal of Clinical and Experimental Pathology11 (2015): 15234.
  17. Dogan NU., et al. “The basics of sentinel lymph node biopsy: anatomical and pathophysiological considerations and clinical aspects”. Journal of Oncology (2019).
  18. Mokhtari S. “Mechanisms of cyst formation in metastatic lymph nodes of head and neck squamous cell carcinoma”. Diagnostic Pathology1 (2012): 1-5.
  19. Ferrer R. “Lymphadenopathy: differential diagnosis and evaluation”. American Family Physician6 (1998): 1313.
Citation: Baraa Faiez Rajab., et al. “Overview of Lymphadenopathy Causes and Diagnosis”. EC Microbiology 18.8 (2022): 89-97.

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