Literature Review
Volume 18 Issue 7 - 2022
Colorectal Cancer and Campylobacter rectus, C. showae and C. concisus
Caroline Herløv1*, Stine Sloth2 and Leif Percival Andersen1
1Department Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
2Department of Stomach, Intestine and Liver Diseases, Herlev Hospital, Herlev, Denmark
*Corresponding Author: Caroline Herløv, Medical Student, Department Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Received: May 01, 2022; Published: June 30, 2022


The correlation between colorectal cancer and Campylobacter spp. was investigated in this review. 10 studies from 3 different databases were found useful to evaluate a possible correlation.

Focus has relied on the intestinal microbiome and its composition in colorectal cancer patients. Possible carcinogenic mechanisms of Campylobacter spp. were investigated. Studies presented in this review, showed a high incidence of Campylobacter spp. in the microbiome of patients with colorectal cancer.

In case of infection with Campylobacter spp. the permeability of the membrane in the infected cells and the stability of the cell will change with possible loss of function as a result. Due to Campylobacter spp. ability to induce the expression of COX-2 and IL-8 it seems that Campylobacter spp. possesses possible pathogenic and carcinogenic capabilities. It can be concluded that Campylobacter spp. are able to invade cells and cause inflammation, including IBD. In conclusion further investigation and studies are needed to verify a correlation between colorectal cancer and Campylobacter spp.

Keywords: Colorectal Cancer; Microbiota; Microbiome; Carcinogenesis; Campylobacter spp


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Citation: Caroline Herløv., et al. “Colorectal Cancer and Campylobacter rectus, C. showae and C. concisus”. EC Microbiology 18.7 (2022): 39-44.

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