Literature Review
Volume 18 Issue 7 - 2022
Colorectal Cancer and Campylobacter rectus, C. showae and C. concisus
Caroline Herløv1*, Stine Sloth2 and Leif Percival Andersen1
1Department Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark
2Department of Stomach, Intestine and Liver Diseases, Herlev Hospital, Herlev, Denmark
*Corresponding Author: Caroline Herløv, Medical Student, Department Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), Copenhagen, Denmark.
Received: May 01, 2022; Published: June 30, 2022




Abstract

The correlation between colorectal cancer and Campylobacter spp. was investigated in this review. 10 studies from 3 different databases were found useful to evaluate a possible correlation.

Focus has relied on the intestinal microbiome and its composition in colorectal cancer patients. Possible carcinogenic mechanisms of Campylobacter spp. were investigated. Studies presented in this review, showed a high incidence of Campylobacter spp. in the microbiome of patients with colorectal cancer.

In case of infection with Campylobacter spp. the permeability of the membrane in the infected cells and the stability of the cell will change with possible loss of function as a result. Due to Campylobacter spp. ability to induce the expression of COX-2 and IL-8 it seems that Campylobacter spp. possesses possible pathogenic and carcinogenic capabilities. It can be concluded that Campylobacter spp. are able to invade cells and cause inflammation, including IBD. In conclusion further investigation and studies are needed to verify a correlation between colorectal cancer and Campylobacter spp.

Keywords: Colorectal Cancer; Microbiota; Microbiome; Carcinogenesis; Campylobacter spp

References

  1. Elsalem L., et al. “The Bacterial Microbiota of Gastrointestinal Cancers: Role in Cancer Pathogenesis and Therapeutic Perspectives”. Clinical and Experimental Gastroenterology 13 (2020): 151-185.
  2. Kuipers EJ., et al. “Colorectal cancer”. Nature reviews”. Disease Primers 1 (2015): 15065.
  3. Kumar V., et al. “Robbins Basic Pathology (10th) (Chapter 15)”. Philadelphia, Pennsylvania: Elsevier (2018).
  4. Nachamkin I., et al. “Campylobacter (3rd)”. Washington, DC: ASM Press (2008).
  5. Kaakoush NO., et al. “Global Epidemiology of Campylobacter Infection”. Clinical Microbiology Reviews3 (2015): 687-720.
  6. Han YW and Wang X. “Mobile Microbiome”. Journal of Dental Research6 (2013): 485-491.
  7. Zhang Y., et al. “Changes in gut microbiota and plasma inflammatory factors across the stages of colorectal tumorigenesis: a case-control study”. BMC Microbiology (2018): 18.
  8. Gemmell MR., et al. “Comparative genomics of Campylobacter concisus: Analysis of clinical strains reveals genome diversity and pathogenic potential”. Emerging Microbes and Infections 7 (2018).
  9. Warren RL., et al. “Co-occurrence of anaerobic bacteria in colorectal carcinomas”. Microbiome 1 (2013): 16.
  10. Deshpande NP., et al. “Campylobacter concisus pathotypes induce distinct global responses in intestinal epithelial cells”. Scientific Reports 6 (2016).
  11. Kaakoush NO., et al. “Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus”. Infection and Immunity2 (2015): 832-845.
  12. Ovesen S., et al. “Motility and biofilm formation of the emerging gastrointestinal pathogen Campylobacter concisus differs under microaerophilic and anaerobic environments”. Gut Microbes1 (2018): 34-44.
  13. Lee D., et al. “Association between oral health and colorectal adenoma in a screening population”. Medicine37 (2018).
  14. Ismail Y., et al. “The Effects of Oral and Enteric Campylobacter concisus Strains on Expression of TLR4, MD-2, TLR2, TLR5 and COX-2 in HT-29 Cells”. PLoS ONE2 (2013).
  15. Amer A., et al. “The Microbiome of Potentially Malignant Oral Leukoplakia Exhibits Enrichment for Fusobacterium, Leptotrichia, Campylobacter, and Rothia Species”. Frontiers in Microbiology 8 (2017).
  16. Man SM., et al. “Host Attachment, Invasion, and Stimulation of Proinflammatory Cytokines by Campylobacter concisus and Other Non-Campylobacter jejuni Campylobacter Species | The Journal of Infectious Diseases | Oxford Academic”. Hentet 16 (2020).
  17. Thun MJ., et al. “Nonsteroidal Anti-Inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues”. Journal of the National Cancer Institute4 (2002): 252-266.
  18. Blaser MJ., et al. “Infections of the Gastrointestinal Tract (Chapter)”. New York, NY: Raven Press (1995): 56-57.
  19. Resende de Paiva C. “Kompendium i Patologi (1st edition)”. Frederiksberg C, DK: Kompendie For laget.
  20. Ning Y and Lenz HJ. “Targeting IL-8 in colorectal cancer”. Expert Opinion on Therapeutic Targets5 (2012): 491-497.
  21. Omrane I., et al. “MicroRNAs 146a and 147b Biomarkers for Colorectal Tumor’s Localization”. BioMed Research International (2014).
  22. Liu S., et al. “A miR-221/222-mediated feedback loop maintains constitutive activation of NF-κB and STAT3 signaling in human colorectal cancers”. Gastroenterology4 (2014): 847-859.e11.
  23. Castellarin M., et al. “Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma”. Genome Research2 (2012): 299-306.
  24. Kostic AD., et al. “Genomic analysis identifies association of Fusobacterium with colorectal carcinoma”. Genome Research2 (2012): 292-298.
  25. McCoy AN., et al. “Fusobacterium Is Associated with Colorectal Adenomas”. PLoS ONE1 (2013).
  26. Rubinstein MR., et al. “Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-cadherin/β-catenin signaling via its FadA adhesin”. Cell Host and Microbe2 (2013): 195-206.
  27. Flanagan L., et al. “Fusobacterium Nucleatum Associates with Stages of Colorectal Neoplasia Development, Colorectal Cancer and Disease Outcome”. European Journal of Clinical Microbiology and Infectious Diseases: Official Publication of the European Society of Clinical Microbiology8 (2014): 1381-1390.
Citation: Caroline Herløv., et al. “Colorectal Cancer and Campylobacter rectus, C. showae and C. concisus”. EC Microbiology 18.7 (2022): 39-44.

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