Review Article
Volume 18 Issue 5 - 2022
Review Malaria and Endemic Burkitt’s Lymphoma: Effects of the Parasite on the Pathogenesis of the Malignancy
Seifegebriel Teshome*
Department of Microbiology Immunology and Parasitology, Addis Ababa University, Ethiopia
*Corresponding Author: Seifegebriel Teshome, Department of Microbiology Immunology and Parasitology, Addis Ababa University, Ethiopia.
Received: March 16, 2022; Published: April 29, 2022


Burkitt lymphoma is the most common childhood cancer in equatorial Africa. A major risk factor in the development of endemic Burkitt lymphoma is Plasmodium falciparum malaria and Epstein-Barr virus exposure. EBV seropositivity in most African children is by three years of age with some infected before six months of age. EBV reactivation and Chronic or repeated P. falciparum coinfection.

Malaria transmission intensity can affect the age at which children become infected with EBV and contribute to a greater EBV burden in infected children. The frequency of EBV and BL co-infection varies depending on the patient group and geographical location. By deregulating the oncogene c-MYC via chromosomal translocation, EBV may have a role in the pathogenesis of BL.

Since its discovery, the epidemiological link between eBL and P. falciparum malaria has been frequently proven. Antigens specific to P. falciparum activate polyclonal B cells and improve the survival of EBV-infected B cells. Learning how to suppress or divert signaling pathways that interfere with normal EBV immune surveillance, as well as gaining a better knowledge of how chronic malaria contributes to eBL pathogenesis, could help avoid this pediatric malignancy in Africa. There will also be a discussion of unanswered topics and preventative techniques.

Keywords: Epstein-Barr Virus; Plasmodium Falciparum; Endemic Burkitt’s Lymphoma; B-Cell


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Citation: Seifegebriel Teshome. “Review Malaria and Endemic Burkitt’s Lymphoma: Effects of the Parasite on the Pathogenesis of the Malignancy”. EC Microbiology 18.5 (2022): 85-91.

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