Review Article
Volume 18 Issue 5 - 2022
Review Malaria and Endemic Burkitt’s Lymphoma: Effects of the Parasite on the Pathogenesis of the Malignancy
Seifegebriel Teshome*
Department of Microbiology Immunology and Parasitology, Addis Ababa University, Ethiopia
*Corresponding Author: Seifegebriel Teshome, Department of Microbiology Immunology and Parasitology, Addis Ababa University, Ethiopia.
Received: March 16, 2022; Published: April 29, 2022




Abstract

Burkitt lymphoma is the most common childhood cancer in equatorial Africa. A major risk factor in the development of endemic Burkitt lymphoma is Plasmodium falciparum malaria and Epstein-Barr virus exposure. EBV seropositivity in most African children is by three years of age with some infected before six months of age. EBV reactivation and Chronic or repeated P. falciparum coinfection.

Malaria transmission intensity can affect the age at which children become infected with EBV and contribute to a greater EBV burden in infected children. The frequency of EBV and BL co-infection varies depending on the patient group and geographical location. By deregulating the oncogene c-MYC via chromosomal translocation, EBV may have a role in the pathogenesis of BL.

Since its discovery, the epidemiological link between eBL and P. falciparum malaria has been frequently proven. Antigens specific to P. falciparum activate polyclonal B cells and improve the survival of EBV-infected B cells. Learning how to suppress or divert signaling pathways that interfere with normal EBV immune surveillance, as well as gaining a better knowledge of how chronic malaria contributes to eBL pathogenesis, could help avoid this pediatric malignancy in Africa. There will also be a discussion of unanswered topics and preventative techniques.

Keywords: Epstein-Barr Virus; Plasmodium Falciparum; Endemic Burkitt’s Lymphoma; B-Cell

References

  1. Burkitt D. “A sarcoma involving the jaws in African children”. British Journal of Surgery 46 (1958): 218-223.
  2. Chêne A., et al. “A molecular link between malaria and Epstein–Barr virus reactivation”. PLOS Pathogens6 (2007): e80.
  3. , et al. “!!! INVALID CITATION !!! (Jaffe and Pittaluga, (2011).
  4. Magrath I. “The pathogenesis of Burkitt's lymphoma”. Advances in Cancer Research (1990): 133-270.
  5. Organization WH. World malaria report 2020: 20 years of global progress and challenges (2020).
  6. Hämmerl L., et al. “The burden of Burkitt lymphoma in Africa”. Infectious Agents and Cancer1 (2019): 17.
  7. Moormann AM., et al. “The company malaria keeps: how co-infection with Epstein-Barr virus leads to endemic Burkitt lymphoma”. Current Opinion in Infectious Diseases5 (2011): 435.
  8. Bouvard V., et al. “Carcinogenicity of malaria and of some polyomaviruses”. Elsevier (2012).
  9. Parkin DM., et al. Cancer Epidemiology and Prevention Biomarkers 23.6 (2014): 953-966.
  10. Thorley-Lawson DA and Allday MJ. “The curious case of the tumour virus: 50 years of Burkitt's lymphoma”. Nature Reviews Microbiology12 (2008): 913-924.
  11. Ashley EA., et al. Malaria 391.10130 (2018): 1608-1621.
  12. Emmanuel B., et al. “African Burkitt lymphoma: age-specific risk and correlations with malaria biomarkers”. The American Journal of Tropical Medicine and Hygiene3 (2011): 397-401.
  13. Moormann AM., et al. “Exposure to holoendemic malaria results in elevated Epstein-Barr virus loads in children”. The Journal of Infectious Diseases8 (2005): 1233-1238.
  14. Donati D., et al. “Identification of a polyclonal B-cell activator in Plasmodium falciparum”. Infection and Immunity9 (2004): 5412-5418.
  15. Thorley-Lawson D., et al. The link between Plasmodium falciparum malaria and endemic Burkitt’s lymphoma-new insight into a 50-year-old enigma 12.1 (2016): e1005331.
  16. Ramiro AR., et al. AID is required for c-myc/IgH chromosome translocations in vivo4 (2004): 431-438.
  17. Jaffe ES. Pathology and genetics of tumours of haematopoietic and lymphoid tissues: Iarc (2001).
  18. Kalisz K., et al. “An update on Burkitt lymphoma: a review of pathogenesis and multimodality imaging assessment of disease presentation, treatment response, and recurrence”. Insights in to Imaging1 (2019): 56.
  19. Van Den Bosch C. “Is endemic Burkitt's lymphoma an alliance between three infections and a tumour promoter?” The Lancet Oncology12 (2004): 738-746.
  20. Schmitz R., et al. “Oncogenic mechanisms in Burkitt lymphoma”. Cold Spring Harbor Perspectives in Medicine2 (2014): a014282.
  21. Magrath IJBjoh. “Epidemiology: clues to the pathogenesis of Burkitt lymphoma 156.6 (2012): 744-756.
  22. Hochberg D., et al. “Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo1 (2004): 239-244.
  23. Orem J., et al. “Burkitt\'s lymphoma in Africa, a review of the epidemiology and etiology 7.3 (2007).
  24. Donati D., et al. “Increased B cell survival and preferential activation of the memory compartment by a malaria polyclonal B cell activator”. The Journal of Immunology5 (2006): 3035-3044.
  25. Kohn C., et al. “Mechanism for long-term survival discovered”. Immunotherapy Weekly (2002): 12-13.
  26. Calderwood MA., et al. “Epstein-Barr virus and virus human protein interaction maps”. Proceedings of the National Academy of Sciences18 (2007): 7606-7611.
  27. Rainey JJ., et al. “Spatial distribution of Burkitt’s lymphoma in Kenya and association with malaria risk”. Tropical Medicine and International Health8 (2007): 936-943.
  28. Burkitt D and Wright D. “Geographical and tribal distribution of the African lymphoma in Uganda”. British Medical Journal5487 (1966): 569.
  29. Biggar RJ., et al. “Primary Epstein‐Barr virus infections in African infants. II. Clinical and serological observations during seroconversion”. International Journal of Cancer3 (1978): 244-250.
  30. Mizuno Y., et al. In-vitro uptake of vitamin A by Plasmodium falciparum 97.3 (2003): 237-243.
  31. Mawson AR and Majumdar SJIjoc. Malaria, Epstein-Barr virus infection and the pathogenesis of Burkitt's lymphoma 141.9 (2017): 1849-1855.
  32. Baruch DI., et al. “Cloning the P. falciparum gene encoding PfEMP1, a malarial variant antigen and adherence receptor on the surface of parasitized human erythrocytes”. Cell 1 (1995): 77-87.
  33. Simone O., et al. TLRs innate immunereceptors and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) CIDR1α-driven human polyclonal B-cell activation 119.2-3 (2011): 144-150.
  34. Frech C and Chen NJPCB. Genome comparison of human and non-human malaria parasites reveals species subset-specific genes potentially linked to human disease 7.12 (2011): e1002320.
  35. Weiss GE., et al. “The Plasmodium falciparum-specific human memory B cell compartment expands gradually with repeated malaria infections”. PLOS Pathogens5 (2010): e1000912.
  36. Asito AS., et al. “Alterations on peripheral B cell subsets following an acute uncomplicated clinical malaria infection in children”. Malaria Journal1 (2008): 238.
  37. Leucci E., et al. “B‐cell differentiation in EBV‐positive Burkitt lymphoma is impaired at posttranscriptional level by miRNA‐altered expression”. International Journal of Cancer6 (2010): 1316-1326.
  38. Potup P., et al. “Blood stage Plasmodium falciparum antigens induce immunoglobulin class switching in human enriched B cell culture”. Southeast Asian Journal of Tropical Medicine and Public Health4 (2009): 651.
  39. He B., et al. “EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switching”. The Journal of Immunology10 (2003): 5215-5224.
  40. Burrows SR., et al. “Understanding human T‐cell‐mediated immunoregulation through herpesviruses”. Immunology and Cell Biology3 (2011): 352-358.
  41. Hislop AD., et al. “Cellular responses to viral infection in humans: lessons from Epstein-Barr virus”. Annual Review of Immunology 25 (2007): 587-617.
  42. Moormann AM., et al. “Exposure to holoendemic malaria results in suppression of Epstein-Barr virus-specific T cell immunosurveillance in Kenyan children”. The Journal of Infectious Diseases6 (2007): 799-808.
  43. Patte C., et al. The Societe Francaise d'Oncologie Pediatrique LMB89 protocol: highly effective multiagent chemotherapy tailored to the tumor burden and initial response in 561 unselected children with B-cell lymphomas and L3 leukemia 97.11 (2001): 3370-3379.
  44. Mbulaiteye SM., et al. African Burkitt's lymphoma: could collaboration with HIV-1 and malaria programmes reduce the high mortality rate? 375.9726 (2010): 1661-1663.
  45. Phillips JAJL. Is Burkitt's lymphoma sexy enough? 368.9554 (2006): 2251-2252.
  46. Moormann AM and Bailey JAJCoiv. Malaria-how this parasitic infection aids and abets EBV-associated Burkitt lymphomagenesis 20 (2016): 78-84.
Citation: Seifegebriel Teshome. “Review Malaria and Endemic Burkitt’s Lymphoma: Effects of the Parasite on the Pathogenesis of the Malignancy”. EC Microbiology 18.5 (2022): 85-91.

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