Review Article
Volume 17 Issue 9 - 2021
Factors Influencing Bone Remodeling in Diabetes Mellitus
Urge Gerema1* and Diriba Dereje2
1Department of Biomedical Sciences, Division of Anatomy, College of Medical Sciences, Institute of Health Sciences, Jimma University, Ethiopia
2Department of Biomedical Sciences, Physiology, College of Medical Sciences, Institute of Health Sciences, Jimma University, Ethiopia
*Corresponding Author: Urge Gerema, Department of Biomedical Sciences, Division of Anatomy, College of Medical Sciences, Institute of Health Sciences, Jimma University, Ethiopia.
Received: May 18, 2021; Published: August 30, 2021


Diabetes Mellitus is group of metabolic disorder that occurs when the pancreas is no longer able to make insulin, or when the body cannot make proper use of the insulin it produce. Diabetes Mellitus increases risk of osteoporosis, interfere with bone formation and impairs bone remodeling. Human skeleton is an important structure in our body, which is influenced by diabetes mellitus. Both Type one diabetes mellitus (T1DM) and type two diabetes mellitus (T2DM) increase osteoporosis, bone formation, bone remodeling. There are different factors influencing bone remodeling in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). These factors are influence on osteoblasts and osteoclasts and reduce the numbers of osteoblasts and bone formation and bone remodeling. Increased advanced glycation end product (AGE) formation, hyper glycaemia, Reactive oxygen species (ROS) production and inflammation are among the common factors that influence the bone remodeling in both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM). The aim of this review was to explore factors influence bone remodeling both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM).

Keywords: Diabetes Mellitus; Bone Fracture Remodeling; Factors


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Citation: Urge Gerema and Diriba Dereje. “Factors Influencing Bone Remodeling in Diabetes Mellitus” EC Microbiology 17.9 (2021): 52-58.

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