Review Article
Volume 17 Issue 3 - 2021
Coronavirus Disease (COVID-19) and the Search for Effective Treatment Options: A Systematic Review
Hamza Sule*, AS Kumurya, MY Gwarzo and AI Adamu
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University, Kano, Nigeria
*Corresponding Author: Hamza Sule, Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University, Kano, Nigeria.
Received: August 16, 2020; Published: February 27, 2021


As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to order, to the global health system, because, as at the moment, there is no nation or group of nations spared off the disease. This review aimed to assess, the journey so far, with regards to the search for effective treatment options for covid-19. Relevant data were obtained using various search engines, like Google,, Bing and yandex among others. In the course of that, it was discovered based on the previous restudies that, many different agents are candidates for treatment of Covid-19. These include antiviral, antibacterial/antiparasitic as well as anti-inflammatory agents. Due to the significance of the disease to public health, World Health Organization (WHO) initiated a large-scale trial called (“Solidarity Trial”), covering many countries and enrolling large number of hospitalized patients at once. This was designed to cut down the normal lengthy period clinical trials and evaluation of drugs takes, by up to 80%. In the course of that, as at 1st July, 2020, a total of 5500 patients were enrolled from 21 out of 36 countries approved to participate. Documented evidence from published works reviewed, also suggest that, Chloroquine/hydroxychloroquine, Remdesivir, Lopinavir-ritonavir and Favipivir; which are primarily; malaria drugs, experimental antiviral drug; HIV drugs combination and immunomodulators respectively, could be used for this fight. However, their function is now further redirected to become (repurposed drugs) to help contain the Covid-19 pandemic, as such their effectiveness is being evaluated in that direction. It could therefore be concluded that, there are some head ways in the search for treatment options, but much more needs to be done to arrive at the desired destination with regards prevention and cure of the Covid-19.

Keywords: Coronavirus Disease; Treatment Options; Solidarity Trial; Repurposed Drugs


  1. World Health Organization. “Report of the WHO – China Joint Mission on Coronavirus Disease 2019 (COVID-19)”. Geneva: WHO (2020).
  2. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. Lancet 395 (2020): 497.
  3. Zhou F., et al. “Clinical course and risk factors for mortality of adult in patients with COVID-19 in Wuhan, China: a retrospective cohort study”. Lancet (2020).
  4. Liu J., et al. “Neutrophil-to-lymphocyte ratio predicts severe illness patients with 2019 novel coronavirus in the early stage”. Med Rxiv (2020).
  5. Cao Q., et al. “SARS-CoV-2 infection in children: transmission dynamics and clinical characteristics”. Journal of the Formosan Medical Association 119 (2020): 670-673.
  6. Huang WH., et al. “Novel coronavirus disease (COVID-19) in Taiwan: reports of two cases from Wuhan, China”. Journal of Microbiology, Immunology and Infection 53 (2019): 481-484.
  7. Chen N., et al. “Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study”. Lancet 395 (2020): 507-513.
  8. Lee PI., et al. “Are children less susceptible to COVID-19?” Journal of Microbiology, Immunology and Infection (2020).
  9. To KW., et al. “Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV2: an observational cohort study”. The Lancet Infectious Diseases (2020).
  10. “Information for Clinicians on Investigational Therapeutics for Patients with COVID-19 Updated April 25, 2020 (CDC 2020) 18 March 2020 WHO Director-General's opening remarks at the media briefing on COVID-19” (2020).
  11. Kupferschmidt K. “WHO launches global megatrial of the four most promising coronavirus treatments”. Science Magazine (2020).
  12. Belhadi D., et al. “A brief review of antiviral drugs evaluated in registered clinical trials for COVID-19”. Med Rxiv (2020).
  13. Touret F and de Lamballerie XOF. “Chloroquine and COVID-19”. Antiviral Research 177 (2020): 104762.
  14. Wilde AH., et al. “Screening of an FDA-approved compound library identifies four small-molecule inhibitors of Middle East respiratory syndrome coronavirus replication in cell culture”. Antimicrobial Agents and Chemotherapy 58 (2014) 4875-4884.
  15. Keyaerts E., et al. “In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine”. Biochemical and Biophysical Research Communication 323 (2004): 264-268.
  16. Wang M., et al. “Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) In vitro”. Cell Research 30 (2020): 269-271.
  17. Gao J., et al. “Breakthrough: chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies”. Bioscience Trends 14 (2020): 72-73.
  18. Gautret P., et al. “Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial”. International Journal of Antimicrobial Agents (2020): 105949.
  19. Warren TK., et al. “Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys”. Nature 531 (2016): 381-385.
  20. Sheahan TP., et al. “Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses”. Science Translational Medicine 9 (2017): eaal3653.
  21. Sheahan TP., et al. “Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV”. Nature Communication 11 (2020): 1-14.
  22. Holshue ML., et al. “First case of 2019 novel coronavirus in the United States”. The New England Journal of Medicine 382 (2020): 929-936.
  23. Chan JFW., et al. “Broad-spectrum antivirals for the emerging Middle East respiratory syndrome coronavirus”. Journal of Infection 67 (2013): 606-616.
  24. Chan KS., et al. “Treatment of severe acute respiratory syndrome with lopinavir/ritonavir: a multicentre retrospective matched cohort study”. The Hong Kong Journal of Emergency Medicine 9 (2003): 399-406.
  25. Delang L., et al. “Favipiravir as a potential countermeasure against neglected and emerging RNA viruses”. Antiviral Research 153 (2018): 85-94.
  26. Cai Q., et al. “Experimental treatment with favipiravir for COVID-19: an open-label control study”. Engineering (2020).
Citation: Hamza Sule., et al. “Coronavirus Disease (COVID-19) and the Search for Effective Treatment Options: A Systematic Review”. EC Microbiology 17.3 (2021): 38-43.

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