Review Article
Volume 17 Issue 3 - 2021
Coronavirus Disease (COVID-19) and the Search for Effective Treatment Options: A Systematic Review
Hamza Sule*, AS Kumurya, MY Gwarzo and AI Adamu
Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University, Kano, Nigeria
*Corresponding Author: Hamza Sule, Department of Medical Laboratory Science, Faculty of Allied Health Sciences, College of Health Sciences, Bayero University, Kano, Nigeria.
Received: August 16, 2020; Published: February 27, 2021




Abstract

As corona virus disease (Covid-19) reaches a pandemic status within short time, it is a call to order, to the global health system, because, as at the moment, there is no nation or group of nations spared off the disease. This review aimed to assess, the journey so far, with regards to the search for effective treatment options for covid-19. Relevant data were obtained using various search engines, like Google, Ask.com, Bing and yandex among others. In the course of that, it was discovered based on the previous restudies that, many different agents are candidates for treatment of Covid-19. These include antiviral, antibacterial/antiparasitic as well as anti-inflammatory agents. Due to the significance of the disease to public health, World Health Organization (WHO) initiated a large-scale trial called (“Solidarity Trial”), covering many countries and enrolling large number of hospitalized patients at once. This was designed to cut down the normal lengthy period clinical trials and evaluation of drugs takes, by up to 80%. In the course of that, as at 1st July, 2020, a total of 5500 patients were enrolled from 21 out of 36 countries approved to participate. Documented evidence from published works reviewed, also suggest that, Chloroquine/hydroxychloroquine, Remdesivir, Lopinavir-ritonavir and Favipivir; which are primarily; malaria drugs, experimental antiviral drug; HIV drugs combination and immunomodulators respectively, could be used for this fight. However, their function is now further redirected to become (repurposed drugs) to help contain the Covid-19 pandemic, as such their effectiveness is being evaluated in that direction. It could therefore be concluded that, there are some head ways in the search for treatment options, but much more needs to be done to arrive at the desired destination with regards prevention and cure of the Covid-19.

Keywords: Coronavirus Disease; Treatment Options; Solidarity Trial; Repurposed Drugs

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Citation: Hamza Sule., et al. “Coronavirus Disease (COVID-19) and the Search for Effective Treatment Options: A Systematic Review”. EC Microbiology 17.3 (2021): 38-43.

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