Opinion
Volume 17 Issue 2 - 2021
Gut Microbiota - Preventive and Therapeutic Approach in Management of diseases
Shrihari TG*
Assistant Professor, Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru, India
*Corresponding Author: Shrihari TG, Assistant Professor, Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru, India.
Received: January 02, 2021; Published: January 27, 2021




Gut microorganisms governs human health, gut micro biota is a diversified microbial colonies consist of symbiotic bacteria’s, viruses, fungi and protozoa’s. There are around 2 - 3 billion germs are present in only in gut, which are involved in anti-inflammatory activity and immunity [1-5,10-13]. Pathogen associated molecular patterns (PAMPs) such as LPS (Lipopolysaccharide) of bacteria’s and surface glycoprotein of viruses recognized by pattern recognition receptor, which belongs to toll like receptors (TLRs) activate NF-KB a key transcription factor, which inter activate immune mediators such as cytokines in (IL-2, TNF-α, TGF-β, IL- 12, interferon ϒ, IL-17) from inflammatory cells such as macrophages, neutrophils, mast cells, natural killer cells, dendritic cells involving innate and adaptive immunity [1,6-9,14,15].

References

  1. Baohong W., et al. “The human microbiota in health and disease”. Engineering1 (2017): 71-82.
  2. Franzosa EA., et al. “Relating the metatranscriptome and metagenome of the human gut”. Proceedings of the National Academy of Sciences of the United States of America 22 (2014): E2329-E2338.
  3. Yamashiro Y. “Gut microbiota in health and disease”. Annals of Nutrition and Metabolism 3-4 (2017): 242-246.
  4. Icaza-Chávez ME. “Gut microbiota in health and disease”. Revista de Gastroenterología de México 4 (2013): 240-248.
  5. Tremaroli V and Bäckhed F. “Functional interactions between the gut microbiota and host metabolism”. Nature 7415 (2012): 242-249.
  6. Castellarin M., et al. “Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma”. Genome Research 2 (2012): 299-306.
  7. Burcelin R. “Gut microbiota and immune crosstalk in metabolic disease”. Molecular Metabolism 9 (2016): 771-781.
  8. Ursell LK., et al. “The intestinal metabolome: an intersection between microbiota and host”. Gastroenterology6 (2014): 1470-1476.
  9. Round JL and Mazmanian SK. “The gut microbiota shapes intestinal immune responses during health and disease”. Nature Reviews Immunology 5 (2009): 313-323.
  10. Grehan MJ., et al. “Durable alteration of the colonic microbiota by the administration of donor fecal flora”. Journal of Clinical Gastroenterology 8 (2010): 551-561.
  11. Zarco MF., et al. “The oral microbiome in health and disease and the potential impact on personalized dental medicine”. Oral Diseases 2 (2012): 109-120.
  12. Rodrigues Hoffmann A., et al. “The microbiome: The trillions of microorganisms that maintain health and cause disease in humans and companion animals”. Veterinary Pathology 1 (2016): 10-21.
  13. Integrative HMP (iHMP) Research Network Consortium (2014) The integrative human microbiome project: Dynamic analysis of microbiome-host omics profiles during periods of human health and disease”. Cell Host and Microbe 3 (2014): 276-289.
  14. Yost S., et al. “Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis”. Genome Medicine 1 (2015): 27.
  15. Xiong W., et al. “Development of an enhanced metaproteomic approach for deepening the microbiome characterization of the human infant gut”. Journal of Proteome Research 1 (2015): 133-141.
  16. Faith JJ., et al. “Creating and characterizing communities of human gut microbes in gnotobiotic mice”. The ISME Journal 9 (2010): 1094-1098.
  17. Human Microbiome Project C. “A framework for human microbiome research”. Nature7402 (2012): 215-221.
  18. Khoruts A., et al. “Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea”. Journal of Clinical Gastroenterology 5 (2010): 354-360.
  19. Silverman MS., et al. “Success of self-administered home fecal transplantation for chronic Clostridium difficile infection”. Clinical Gastroenterology and Hepatology 5 (2010): 471-473.
  20. De Martel C., et al. “Global burden of cancers attributable to infections in 2008: a review and synthetic analysis”. The Lancet Oncology 6 (2012): 607-615.
Citation: Shrihari TG. “Gut Microbiota - Preventive and Therapeutic Approach in Management of diseases”. EC Microbiology 17.2 (2021): 251-252.

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