Volume 17 Issue 2 - 2021
Gut Microbiota - Preventive and Therapeutic Approach in Management of diseases
Shrihari TG*
Assistant Professor, Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru, India
*Corresponding Author: Shrihari TG, Assistant Professor, Department of Oral Medicine and Oral Oncology, Krishnadevaraya College of Dental Sciences, Bengaluru, India.
Received: January 02, 2021; Published: January 27, 2021

Gut microorganisms governs human health, gut micro biota is a diversified microbial colonies consist of symbiotic bacteria’s, viruses, fungi and protozoa’s. There are around 2 - 3 billion germs are present in only in gut, which are involved in anti-inflammatory activity and immunity [1-5,10-13]. Pathogen associated molecular patterns (PAMPs) such as LPS (Lipopolysaccharide) of bacteria’s and surface glycoprotein of viruses recognized by pattern recognition receptor, which belongs to toll like receptors (TLRs) activate NF-KB a key transcription factor, which inter activate immune mediators such as cytokines in (IL-2, TNF-α, TGF-β, IL- 12, interferon ϒ, IL-17) from inflammatory cells such as macrophages, neutrophils, mast cells, natural killer cells, dendritic cells involving innate and adaptive immunity [1,6-9,14,15].


  1. Baohong W., et al. “The human microbiota in health and disease”. Engineering1 (2017): 71-82.
  2. Franzosa EA., et al. “Relating the metatranscriptome and metagenome of the human gut”. Proceedings of the National Academy of Sciences of the United States of America 22 (2014): E2329-E2338.
  3. Yamashiro Y. “Gut microbiota in health and disease”. Annals of Nutrition and Metabolism 3-4 (2017): 242-246.
  4. Icaza-Chávez ME. “Gut microbiota in health and disease”. Revista de Gastroenterología de México 4 (2013): 240-248.
  5. Tremaroli V and Bäckhed F. “Functional interactions between the gut microbiota and host metabolism”. Nature 7415 (2012): 242-249.
  6. Castellarin M., et al. “Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma”. Genome Research 2 (2012): 299-306.
  7. Burcelin R. “Gut microbiota and immune crosstalk in metabolic disease”. Molecular Metabolism 9 (2016): 771-781.
  8. Ursell LK., et al. “The intestinal metabolome: an intersection between microbiota and host”. Gastroenterology6 (2014): 1470-1476.
  9. Round JL and Mazmanian SK. “The gut microbiota shapes intestinal immune responses during health and disease”. Nature Reviews Immunology 5 (2009): 313-323.
  10. Grehan MJ., et al. “Durable alteration of the colonic microbiota by the administration of donor fecal flora”. Journal of Clinical Gastroenterology 8 (2010): 551-561.
  11. Zarco MF., et al. “The oral microbiome in health and disease and the potential impact on personalized dental medicine”. Oral Diseases 2 (2012): 109-120.
  12. Rodrigues Hoffmann A., et al. “The microbiome: The trillions of microorganisms that maintain health and cause disease in humans and companion animals”. Veterinary Pathology 1 (2016): 10-21.
  13. Integrative HMP (iHMP) Research Network Consortium (2014) The integrative human microbiome project: Dynamic analysis of microbiome-host omics profiles during periods of human health and disease”. Cell Host and Microbe 3 (2014): 276-289.
  14. Yost S., et al. “Functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis”. Genome Medicine 1 (2015): 27.
  15. Xiong W., et al. “Development of an enhanced metaproteomic approach for deepening the microbiome characterization of the human infant gut”. Journal of Proteome Research 1 (2015): 133-141.
  16. Faith JJ., et al. “Creating and characterizing communities of human gut microbes in gnotobiotic mice”. The ISME Journal 9 (2010): 1094-1098.
  17. Human Microbiome Project C. “A framework for human microbiome research”. Nature7402 (2012): 215-221.
  18. Khoruts A., et al. “Changes in the composition of the human fecal microbiome after bacteriotherapy for recurrent Clostridium difficile-associated diarrhea”. Journal of Clinical Gastroenterology 5 (2010): 354-360.
  19. Silverman MS., et al. “Success of self-administered home fecal transplantation for chronic Clostridium difficile infection”. Clinical Gastroenterology and Hepatology 5 (2010): 471-473.
  20. De Martel C., et al. “Global burden of cancers attributable to infections in 2008: a review and synthetic analysis”. The Lancet Oncology 6 (2012): 607-615.
Citation: Shrihari TG. “Gut Microbiota - Preventive and Therapeutic Approach in Management of diseases”. EC Microbiology 17.2 (2021): 251-252.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for upcoming Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 21, 2021.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk