Research Article
Volume 17 Issue 2 - 2021
Visual Outcome and Quality of Life after Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK)
Basil Alhusssin1*, Nourah Altuwaijri2, Rabia Bashir1, Shiji Gangadharan1, Albandary Alhamzah2 and Fahad Alfardan1
1King Abdulaziz Medical City, Riyadh, Saudi Arabia
2King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
*Corresponding Author: Basil Alhusssin, King Abdulaziz Medical City, Riyadh, Saudi Arabia..
Received: January 16, 2021; Published: January 20, 2021




Abstract

Purpose: To evaluate the visual outcome and patient-related quality of life (QoL) after Descemets stripping automated endothelial keratoplasty (DSAEK).

Methods: Patients were enrolled if they had pseudophakic bullous keratopathy or Fuchs endothelial dystrophy and underwent DSAEK. Data were collected on patient demographics and best corrected visual acuity (BCVA) before and after DSAEK. Patients completed the National Eye Institute Visual Functioning Questionnaire - 39 (NEI VFQ-39) at least 1 year after DSAEK. Descriptive statistics are reported. The Student t-test was used to compare means between genders. A P value less than 0.05 was considered statistically significant.

Results: The study sample was comprised of 13 patients. Preoperatively, one eye had BCVA 20/100 and all other eyes had vision < 20/200. At last postoperative visit, BCVA improved by 2 or more lines in all eyes. The mean improvement in BCVA was 2.5 lines. Complications after DSAEK included rejection in 2 eyes for which DSAEK was repeated without further sequelae. The NEI VFQ-39 total score was 84.25 ± 18.96. The scores per subscales varied from 72.5 ± 21.38 for the “General health” subscale to 93.27 ± 10.66 for the “Dependency” subscale (Table 2). There were no statistically significant differences between genders for the different subscales (P < 0.05, all between-gender subscale comparisons).

Conclusion: A clinically significant increase in BCVA improved patient related quality of life.

Keywords: Quality of Life (QoL); Descemets Stripping Automated Endothelial Keratoplasty (DSAEK); Best Corrected Visual Acuity (BCVA)

References

  1. Sorkin N., et al. “Outcomes of Descemet Membrane Endothelial Keratoplasty in Eyes With a Previous Descemet Stripping Automated Endothelial Keratoplasty Graft”. Cornea 6 (2018): 678-681.
  2. Williams KA., et al. “Long-term outcome after corneal transplantation. Visual result and patient perception of success”. Ophthalmology5 (1991): 651-657.
  3. Melles GR., et al. “A surgical technique for posterior lamellar keratoplasty”. Cornea 6 (1998): 618-626.
  4. Melles GRJ., et al. “A technique to excise the Descemet membrane from a recipient cornea (descemetorhexis)”. Cornea3 (2004): 286-288.
  5. Gorovoy MS. “Descemet-stripping automated endothelial keratoplasty”. Cornea 25 (2006): 886-889.
  6. Melles GRJ Ong., et al. “Descemet membrane endothelial keratoplasty (DMEK)”. Cornea8 (2006): 987-990.
  7. Busin M Madi., et al. “Ultrathin descemets stripping automated endothelial keratoplasty with the microkeratome double-pass technique: two-year outcomes”. Ophthalmology6 (2013): 1186-1194.
  8. Price MO and Price FW. “Descemet’s stripping endothelial keratoplasty”. Current Opinion in Ophthalmology 18 (2007): 290-294.
  9. Mitry D., et al. “Descemet Stripping Automated Endothelial Keratoplasty After Failed Penetrating KeratoplastySurvival, Rejection Risk, and Visual Outcome”. JAMA Ophthalmology 6 (2014): 742-749.
  10. Park CY Lee., et al. “Keratoplasty in the United States: A 10-Year Review from 2005 through 2014”. Ophthalmology12 (2015): 2432-2442.
  11. Lee WB., et al. “Descemet’s stripping endothelial keratoplasty: Safety and outcomes: A report by the American Academy of Ophthalmology”. Ophthalmology 116 (2009): 1818‐1830.
  12. Bahar I., et al. “Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty”. Ophthalmology 115 (2008): 1525-1533.
  13. Hjortdal J and Ehlers N. “Descemet’s stripping automated endothelial keratoplas- ty and penetrating keratoplasty for Fuchs’ endothelial dystrophy”. Acta Ophthalmology 87 (2009): 310-314.
  14. McLaren JW., et al. “Corneal wavefront errors 24 months after deep lamellar endothelial keratoplasty and penetrating keratoplasty”. American Journal of Ophthalmology 147 (2009): 959-965.
  15. Price MO., et al. “Descemet’s stripping automated endothelial keratoplasty outcomes compared with penetrating keratoplasty from the Cornea Donor Study”. Ophthalmology 117 (2010): 438‐444.
  16. Price MO and Price FW. “Endothelial cell loss after descemet stripping with endothelial keratoplasty in uencing factors and 2‐year trend”. Ophthalmology 115 (2008): 857‐865.
  17. Yoeruek E., et al. “Histological and ultrastructural findings of corneal tissue after failed descemet membrane endothelial keratoplasty”. Acta Ophthalmologica 92 (2014): e213-e216.
  18. Dirisamer M., et al. “Identifying causes for poor visual outcome after DSEK/DSAEK following secondary DMEK in the same eye”. Acta Ophthalmologica 91 (2013): 131-139.
  19. Ham L., et al. “Secondary DMEK for poor visual outcome after DSEK”. Cornea 29 (2010): 1278-1283.
  20. Weller JM., et al. “Descemet membrane endothelial keratoplasty as treatment for graft failure after Descemet stripping automated endothelial keratoplasty”. American Journal of Ophthalmology 159 (2015): 1050- 1057.
  21. Mangione CM., et al. “National Eye Institute Visual Function Questionnaire Field Test Investigators. Development of the 25-item National Eye Institute Visual Function Questionnaire”. Archives of Ophthalmology 7 (2001): 1050-1058.
  22. Zitte K., et al. “DSAEK after failed penetrating keratoplasty”. The Journal français d'ophtalmologie 1 (2015): 22-33.
  23. Green M and Wilkins M. “Comparison of DSAEK and DMEK learning curves”. Clinical and Experimental Ophthalmology 42 (2014): 85.
  24. Sengupta S., et al. “Driving habits in older patients with central vision loss”. Ophthalmology 121 (2014): 727-732.
Citation: Basil Alhusssin., et al. “Visual Outcome and Quality of Life after Descemet’s Stripping Automated Endothelial Keratoplasty (DSAEK)”. EC Microbiology 17.2 (2021): 196-202.

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