Research Article
Volume 17 Issue 1 - 2021
Platelet-Rich Plasma in the Treatment of Hand, Foot, and Ankle Osteoarthritis: A Systematic Review
Hussein Assaggaf1*, Mohamed Mahmoud Aljondi2, Ziyad Humaidi Alonizi3, Mazen Ali Alshahrani4, Albashiq Mahmoud Albalwi5, Kasseb Mohammad Abaalwakl6, Ahmed Owaid Alruwaili7, Moaz Ahmed Safar5, Bandar Abdulaziz Aljehaiman8, Musaab Fahad Alslaihem9, Bader Abdulaziz Aldakhil10 and Mohammed Saleh Abalharith11
11Consultant of Orthopedics, Department of Orthopedics, East Jeddah Hospital, Jeddah, Saudi Arabia
22Department of Orthopedic, King Abdullah Specialized Children Hospital, Riyadh, Saudi Arabia
33College of Medicine, Alfarabi Colleges, Riyadh, Saudi Arabia
44General Practice, Ahad Rufaidah General Hospital, Khamis Mushait, Saudi Arabia
55College of Medicine, Ibn Sina National College, Jeddah, Saudi Arabia
66Department of Orthopedics, Prince Mutaib bin Abdulaziz Hospital, Aljouf, Saudi Arabia
77College of Medicine, Jouf University, Aljouf, Saudi Arabia
88College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia
99College of Medicine, Imam Muhammad Ibn Saud Islamic University, Riyadh, Saudi Arabia
10College of Medicine, Qassim University, Qassim, Saudi Arabia
11College of Medicine, Masaryk University, Brno, Czech Republic
*Corresponding Author: Hussein Assaggaf, Consultant of Orthopedics, Department of Orthopedics, East Jeddah Hospital, Jeddah, Saudi Arabia.
Received: November 18, 2020; Published: December 10, 2020


Platelet-rich plasma (PRP) administration has been considered an ideal approach for the management of symptomatic joint disorders when other conservative treatments fail to reduce the symptoms. In this systematic review, we aim to discuss the effectiveness of PRP in the management of hand, foot and ankle osteoarthritis as reported by previous studies. For that, we conducted a systematic electronic database search for suitable studies from inception till 22nd October 2020 in nine databases. We included original studies with no restrictions on study design, country, language or publication date. Finally, 13 studies were included in the current study. The current literture shows that PRP injection into the ankle was effective in reducing the pain and enhancing the mobility of this joint 24 weeks after the injection measured by the VAS, Japanese Society for Surgery of the Foot (JSSF), and the self-administered foot evaluation questionnaire (SAFE-Q) scales. For the foot, PRP injection significantly improved the pain and movememnt when compared to the hyaloronic acid (HA) injection; nevertheless, the PRP results were comparable to prolotherapy. For the hand, the patient was able to pursue his daily activities with improved functions, better VAS, DASH scores, and SAFE-Q scores, with a reported high satisfaction from the patient about this treatment modality and its efficacy compared to steroids or lidocaine. However, HA was significantly better at longer outcomes than PRP modality which failed to have a maintained efficacy. In conclusion, among the majority of the studies included, PRP showed a significant improvement in patients receiving for the management of osteoarthritis in small joints involving the hands and feet.

Keywords: Platelet-Rich Plasma; PRP; Arthritis; Hand; Ankle, Feet; Hyaluronic Acid


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Citation: Hussein Assaggaf., et al. “Platelet-Rich Plasma in the Treatment of Hand, Foot, and Ankle Osteoarthritis: A Systematic Review”. EC Microbiology 17.1 (2021): 61-74.

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