Mini Review
Volume 16 Issue 11 - 2020
Why Some Riboswitches are Suitable Targets for Antibacterial Drug Discovery?
Lozena A Otcheva, Nikolet Pavlova, Katya B Popova, Martina Traykovska and Robert Penchovsky*
Department of Genetics, Faculty of Biology, Sofia University “Saint Kliment Ohridski”, Sofia, Bulgaria
*Corresponding Author: Robert Penchovsky, Department of Genetics, Faculty of Biology, Sofia University “Saint Kliment Ohridski”, Sofia, Bulgaria.
Received: October 02, 2020; Published: October 15, 2020


The global spread of a growing number of antibiotic-resistant strains of human pathogenic bacteria imposes the pressing need for the development of novel antibiotics using novel antibacterial drugs. One promising strategy is to use novel targets for antibacterial drug discovery such as bacterial riboswitches. They have conservative and well-known RNA sequences and structures and regulate the synthesis of essential metabolites in different pathogenic bacteria by sensing their presence in the cell. In this review, we summarized three different bioinformatic-based criteria for the assessment of the suitability of riboswitches as suitable drug targets. They enable us to focus our research on the most suitable and promising riboswitches as antibacterial drug targets.

Keywords: Antibiotics; Antibacterial Drug Discovery; Bioinformatics Analyses; Drug Targets; Riboswitches


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Citation: Robert Penchovsky., et al. “Why Some Riboswitches are Suitable Targets for Antibacterial Drug Discovery?”. EC Microbiology 16.11 (2020): 48-51.

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