Mini Review
Volume 16 Issue 10 - 2020
Characterization of the Host Receptor Binding by the Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2), SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Yusra Binte Sikandar, Syeda Muntaka Maniha, Waziha Islam Taaseen and Rashed Noor*
School of Life Sciences (SLS), Independent University, Bangladesh (IUB), Bashundhara, Dhaka, Bangladesh
*Corresponding Author: Rashed Noor, Associate Professor (Microbiology), School of Environment and Life Sciences (SELS), Independent University, Bangladesh (IUB), Bashundhara, Dhaka, Bangladesh.
Received: May 23, 2020; Published: September 10, 2020




Abstract

Current global COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is of the emergency public health concern. Prior to SARS-CoV-2 infection, the epidemics caused by the acute respiratory syndrome coronavirus (SARS-CoV) and by the Middle East respiratory syndrome coronavirus (MERS-CoV) were noticed. Therefore, unravelling the pathogenesis scheme of these β-coronaviruses is of major clinical significance of which the mechanism of viral entry demands the foremost focus. The first and foremost strategy of the viral pathogenicity into the host mostly relies on its entry into the host cell as revealed by the identification of the angiotensin-converting enzyme 2 (ACE2) in case of the ongoing COVID-19 disease caused by the SARS-CoV-2 and by the previous etiological agent SARS-CoV. In case of the initiation of the MERS-CoV infection, the dipeptidyl peptidase 4 (DPP4) was discovered as the host receptor. Since all these receptors play important biochemical and immunological roles on triggering the viral infectivity, current review highlighted on these receptor proteins in a comparative way between these three viruses.

Keywords: Severe acute respiratory coronavirus-2 (SARS-CoV-2); SARS-CoV; The Middle East Respiratory Syndrome (MERS); Angiotensin- Converting Enzyme 2 (ACE 2) Receptor; Dipeptidyl Peptidase 4 (DPP4) Receptor

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Citation: Rashed Noor., et al. “Characterization of the Host Receptor Binding by the Severe Acute Respiratory Coronavirus-2 (SARS-CoV-2), SARS-CoV and the Middle East Respiratory Syndrome Coronavirus (MERS-CoV)”. EC Microbiology 16.10 (2020): 24-27.

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