Research Article
Volume 16 Issue 8 - 2020
Synovial Fluid Lactate for the Diagnosis of Joint Infection: A Systematic Review
Adel Hossny Hegaze1*, Walied Abdulaziz Alaleet2, Ahmad Mohammed Alghraibi3, Abdullah Mohammed Asiri4, Fahad Saad Alshahrani4, Abdulrahman Mudhhi Alabdali5, Taher Ahmed Babkr5, Mohammed Hamdan Alghamdi5, Yasser Abdulrhman Alessa4, Nasser Abdulrhman Altamimi6 and Faisal Fahad Alshammari6
1Assitant Professor, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
2Department of Orthopaedics, Buraydah Central Hospital, Buraydah, Saudi Arabia
3College of Medicine, Masaryk University, Brno, Czechia
4College of Medicine, King Khalid University, Abha, Saudi Arabia
5College of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia
6College of Medicine, Hail University, Hail, Saudi Arabia
*Corresponding Author: Adel Hossny Hegaze, Assistant Professor, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia..
Received: June 16, 2020; Published: July 03, 2020




Abstract

Many host-specific synovial fluid biomarkers were investigated for the diagnosis of joint infections; including lactate, adenosine deaminase, calprotectin, alfa-defensin, alpha-2- macroglobulin, C-reactive protein (CRP), leukocyte esterase, and interleukin-6 (IL-6). Therefore, we aimed to systematically review the current evidence discussing the usage of synovial fluid lactate as a biomarker in the diagnosis of joint infection. The search was conducted through seven databases with the usage of the search, followed by searching the references of included papers to avoid missing relevant included papers. We included papers reporting the use of D-lactate in synovial fluid for the diagnosis of joint infections. Finally, 13 papers, with 2243 recruited patients, were included in the study. In general, the synovial lactate showed a good diagnostic value with an area under the receiver operating characteristic curve (AUC) ranging from 76% [23] to 95% [8]. The sensitivity of diagnosing joint infection ranged from 73.3% [23] to 95.7% [8], while specificity ranged from 66.7% to 96%. In conclusion, the synovial fluid lactate can be used as a screening biomarker for septic arthritis, with having the advantages of being inexpensive, needs a small volume of synovial fluid, and short turnaround time.

Keywords: Lactate; Lactic Acid; Septic Arthritis; Joint Infection

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Citation: Adel Hossny Hegaze., et al. “Synovial Fluid Lactate for the Diagnosis of Joint Infection: A Systematic Review”. EC Microbiology 16.8 (2020): 01-13.

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