Research Article
Volume 16 Issue 7 - 2020
Prevalence and Length of Open Reading Frames Vary Across Randomly Generated Sequences of Different Nucleotide Compositions
Chuan Yang Neo1 and Maurice HT Ling1,2*
1School of Applied Sciences, Temasek Polytechnic, Singapore
2HOHY PTE LTD, Singapore
*Corresponding Author: Maurice HT Ling, School of Applied Sciences, Temasek Polytechnic and HOHY PTE LTD, Singapore.
Received: May 27, 2020; Published: June 18, 2020


The emergence of open reading frames is an important step in the origination of de novo genes. However, the conditions leading to the origination of de novo genes is not well-understood. This study aims to determine the effect of nucleotide composition on the length and occurrence of ORFs by examining various ORF parameters using randomly generated sequences from 85 different nucleotide compositions. Our results suggest that various ORF parameters are significant across different nucleotide compositions (p-value < 1E-120). The average length, standard error of the average length, average maximum length and standard error of the average maximum length of ORFs can be moderately predictable (0.43 < r2 < 0.59) by nucleotide compositions. These results suggest that the prevalence and length of ORFs may be function of the underlying nucleotide composition.

Keywords: Open Reading Frames (ORF); Nucleotide Compositions


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Citation: Chuan Yang Neo and Maurice HT Ling. “Prevalence and Length of Open Reading Frames Vary Across Randomly Generated Sequences of Different Nucleotide Compositions”. EC Microbiology 16.7 (2020): 72-78.

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