Review Article
Volume 5 Issue 7 - 2020
Chronic Heart Failure in Insulin-Treated Patients with Type 2 Diabetes Mellitus: A Systematic Review of Clinical Trials
Meshael Meshal Aljoaid1*, Ramzi Ibrahim Alsulami2, Saeed Saleh Nazih3, Hassan Abdulwahab Aljifri4, Ali Naji Al Nihab5, Turki Sanat Al Harbi6, Raed Fahad Almutairi7, Yusuf Salh Allehaidan8 and Musaab Khalil Albalawi9
1Primary Health Center, Ministry of Health, Taif, Saudi Arabia
2College of Medicine, King Abdulaziz University, Saudi Arabia
3College of Medicine, King Khalid University, Abha, Saudi Arabia
4College of Medicine, Umm Al-Qura University, Mecca, Saudi Arabia
5Department of Emergency Medicine, Anak General Hospital, Eastern Province, Saudi Arabia
6College of Medicine, Shaqra University, Shaqra, Saudi Arabia
7Administration of Specialized Centers and Visiting Doctors, Ministry of Health, Riyadh, Saudi Arabia
8Department of Nephrology and Health Affairs, King Saud Medical City, Riyadh, Saudi Arabia
9Alsharqiyah Primary Health Care Center, Ministry of Health, Yanbu, Saudi Arabia
*Corresponding Author: Meshael Meshal Aljoaid, Primary Health Center, Ministry of Health, Taif, Saudi Arabia.
Received: June 12, 2020; Published: June 23, 2020


It is well established that there is a reciprocal association between heart failure (HF) and type 2 diabetes mellitus (DM). In the current study, we aim to give an overview of chronic HF in insulin-treated patients with type 2 diabetes mellitus. For that, we conducted a systematic electronic database search for suitable studies from inception till 8th June 2020 in seven databases. We included all relevant randomized controlled studies (RCTs) reporting insulin-related chronic HF in patients with type 2 diabetes mellitus. Finally, we included five papers in this systematic review. Patients allocated to Insulin + sulphonylurea had a higher risk of HF with an incidence of 8% compared to 3.6% of patients allocated to conventional treatment. Of patients receiving pioglitazone 45 mg + insulin or pioglitazone 30 mg + insulin, 4 patients experienced HF with an incidence of 1%. For Balaglitazone 20 mg + insulin group or the placebo group, the incidence was 2%, while it was 0% for patients received Balaglitazone 10 mg + insulin. No significant difference was observed between HF hospitalization rates between patients randomized to insulin glargine or standard care (0.63). In conclusion, close monitoring of heart pathologies-especially heart failure- in type 2 DM patients is of extreme importance for improving the quality and expectancy of life in those patients.

Keywords: Insulin; Heart Failure; Diabetes Mellitus


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Citation: Meshael Meshal Aljoaid., et al.. “Chronic Heart Failure in Insulin-Treated Patients with Type 2 Diabetes Mellitus: A Systematic Review of Clinical Trials”. EC Microbiology 16.7 (2020): 58-65.

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