Abstract

Aim: Interleukin-17 (IL-17) family cytokines are involved with the response to Bacillus Calmette-Guérin (BCG) vaccination, and IL-17A and IL-17F share a common IL-17 receptor A (IL-17RA). We evaluated the association of the IL17RA gene polymorphisms with serum IL-17A and IL-17F concentrations in adult BCG osteitis survivors.

Methods: Data on IL17RA rs4819553, rs4819554 and rs4819558 polymorphisms were available from 131 BCG survivors. The three included variations were in full linkage within a cluster of eight single nucleotide polymorphisms (SNPs). Variant IL17RA genotypes were present in 71.3%. In addition, Data on serum IL-17A and IL-17F concentrations were available from 129 adult BCG survivors. The present study is a secondary analysis combining these two datasets.

Results: There were no significant differences in serum IL-17A and IL-17F concentrations in either continuous or categorized analyses between cases with wild versus variant IL17RA genotypes. The categorized analyses were done using the detection limits, the outlier limits, and the limits of 25^th, 50^th and 75^th percentiles. The small number of homozygous variant genotypes (3.1%) did not allow to study them separately.

Conclusion: IL17RA variations showed no association with IL-17A or IL-17F production in Finnish BCG osteitis survivors.

Keywords: Bacillus Calmette Guérin; BCG Osteitis; Gene Polymorphism; Interleukin-17A; Interleukin-17F; Interleukin-17 receptor A

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