Research Article
Volume 16 Issue 4 - 2020
Serum Interleukin-17F in Relation to Genotypes and Haplotypes of Three IL17F Polymorphisms in Bacillus Calmette-Guerin Osteitis Survivors
Matti Korppi1*, Johanna Teräsjärvi2, Alex-Mikael Barkoff2, Eero Lauhkonen1, Heini Huhtala3, Kirsi Nuolivirta4 and Qiushui He5,6
1Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland
2Institute of Biomedicine, University of Turku, Turku, Finland
3Faculty of Social Sciences, University of Tampere, Tampere, Finland
4Department of Pediatrics, Seinäjoki Central Hospital, Seinäjoki, Finland
5Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland
6Department of Medical Microbiology, Capital Medical University, Beijing, China
*Corresponding Author: Matti Korppi, Professor, Center for Child Health Research, Faculty of Medicine and Life Sciences, University of Tampere and University Hospital, Tampere, Finland.
Received: January 27, 2020; Published: March 16, 2020




Abstract

Aim: Interleukin-17 (IL-17) cytokines are encoded by the respective IL17 genes. This paper evaluates the association of three functional IL17F polymorphisms with IL-17F production. 

Design: We studied IL17F rs763780 (N = 132), rs7741835 (N = 131) and rs11465553 (N = 132) polymorphisms and serum IL-17F concentrations (N = 129) in adults who presented with BCG osteitis in early childhood. Serum IL-17F concentrations were evaluated in relation to IL17F genotypes and haplotypes.

Results: The IL17F genotype was variant in 15.1% for the rs763780, in 34.3% for the rs7741835 and in 13.6% for the rs11465553 polymorphism. Thirteen % of the haplotypes comprised two variant IL17F alleles but none comprised all three variant alleles. IL17F genotypes or haplotypes were not associated with serum IL-17F concentrations in continuous nor in categorized analyses.

Conclusion: IL17F gene variations had no impact on IL-17F production. 

Keywords: BCG Osteitis; Gene Polymorphism; Interleukin-17F; IL17F Genotype; IL17F Haplotype

References

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Citation: Matti Korppi., et al. “Serum Interleukin-17F in Relation to Genotypes and Haplotypes of Three IL17F Polymorphisms in Bacillus Calmette-Guerin Osteitis Survivors". EC Microbiology 16.4 (2020): 12-18.

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