Review Article
Volume 16 Issue 3 - 2020
Bacterial Resistance; A Perspective on Beta-Lactamase Enzymes
Orole Olukayode Olugbenga*
Department of Microbiology, Federal University of Lafia, Nigeria
*Corresponding Author: Orole Olukayode Olugbenga, Department of Microbiology, Federal University of Lafia, Nigeria.
Received: November 11, 2019; Published: February 10, 2020




Abstract

Bacteria with resistant genes are spreading fast, from place to place, and genes formerly encoded by the chromosome are now encoded by plasmids, and by lateral transfer can now jump from one bacteria species to a completely new species. Decade of treating bacteria and especially the resistant strains have not brought solace but fear and concern as newer super resistant bacteria are evolving without an equal treatment plan to counter them. Beta-lactamases with their prevalence and increasing types have been successful in raising a worthwhile defense mechanism in bacteria against beta-lactam antibiotics which is the most used group of antibiotics. As a result of the resistance build up to these antibiotics and cost of finding and producing new antibiotics, research has led to a means of overcoming the plague of resistance, hence the introduction of chemical compounds known as inhibitors. Inhibitors work on the premise that beta-lactamase messes up beta-lactam ring of the antibiotic, then the inhibitor messes up the beta-lactamase by deactivation in defense of the antibiotic. They are added to beta-lactam antibiotics to make them more efficient and effective. New antibiotics are seldom produced due to high cost involved, and the saving wall of inhibitors is continually breached by newer version of beta-lactamases. Problem resulting from this failure include increasing cost of treatment, mortalities, and community prone to bacterial resistant scourge. The review summarily highlight the strength of beta-lactamases over beta-lactam antibiotics, and called for pro-active measures to tackle the problem.

Keywords: Bacteria; Resistance; Plasmid; Beta-lactamase; Antibiotics

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Citation: Orole Olukayode Olugbenga. “Bacterial Resistance; A Perspective on Beta-Lactamase Enzymes". EC Microbiology 16.3 (2020): 01-12.

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