Research Article
Volume 15 Issue 6 - 2019
Prevalence of Anemia in Hypothyroidism: Systematic Review and Meta-Analysis
Saeed Awad Alqahtani1*, Nabil Mohammed Alfaify1, Ali Ibrahim Alhilali2, Nawal Misfer Alawadi2, Muhammad Hassan Shubaili2, Salem Jaber Alasiri2, Hatim Saeed Raffaa2, Zeyad Hamdan Alshehri2, Mohammed Abdullah Alshahrani2, Alhassan Mohammed Alhasani2 and Mohammad Abdullah Al Bakkar2
1Department of Internal Medicine, Khamis Mushait General Hospital, Khamis Mushait, Saudi Arabia
2Department of Internal Medicine, Armed Forces Hospital, Khamis Mushait, Saudi Arabia
*Corresponding Author: Saeed Awad Alqahtani, Department of Internal Medicine, Khamis Mushait General Hospital, Khamis Mushait, Saudi Arabia.
Received: May 03, 2019; Published: May 31, 2019


Objective: To evaluate the prevalence rate of different types of anemia in hypothyroidism patients.

Methods: Eight databases were searched systematically for any original study measuring the prevalence rate of anemia in hypothyroidism. In addition, manual search with different methods was performed to retrieve all possible studies. Three independent reviewers scanned retrieved references for possible inclusion.

Results: A total of eight studies were finally included in the meta-analysis of this systematic review. The pooled overall prevalence rate of anemia among hypothyroid patients was 33.77% with 95% CI (21.53 to 52.95). Regarding different types of anemias, the highest prevalence rate was for normocytic anemia [PR (95%) = 46.27 (34.46 to 62.14)] followed by microcytic [PR (95%) = 24.36 (14.68 to 40.44)] and macrocytic anemias [PR (95%) = 16.36 (11.66 to 22.96)], respectively. Regarding different types of hypothyroidism, the prevalence of anemia in overt hypothyroidism was 24.79% (95% CI = 11.01 to 55.81) and 24.47% (95% CI = 13.41 to 44.67) for subclinical hypothyroidism.

Conclusions: The high prevalence of anemia in patients with hypothyroidism suggests screening for hypothyroidism during the differential diagnosis of cases presenting with anemia.

Keywords: Anemia; Hypothyroidism; Prevalence; Screening; Meta-Analysis


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Citation: Saeed Awad Alqahtani., et al. “Prevalence of Anemia in Hypothyroidism: Systematic Review and Meta-Analysis”. EC Microbiology 15.6 (2020): 514-522.

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