Editorial
Volume 9 Issue 1 - 2020
How Close we have Reached in Overcoming the Limiting Factor in IVF-ET Success Namely the Endometrium
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: November 11, 2019; Published: December 04, 2019




With the advances in getting novel stimulation protocols, reproductive immunology, having facilities of embryo culture along with testing technologies, implantation continues to be the step which basically prevents the success in artificial reproductive technology (ART). Earlier we reviewed on how chronic endometritis has become a major factor in limiting implantation and how lot of advances have been achieved in diagnosis and treatment of chronic endometritis (CE) and steps that are being taken to optimize diagnosis and treatment of CE which is one step that might help in improving implantation [1]. Here we discuss another factor creating controversy regarding implantation concerning the role of endometrium thickness at the time of transfer of embryos. There has been no doubt that having the most thick endometrium has >relation with success in implantation at the time of in vitro fertilization (IVF) [2-5]. Almost all of us have had in mind that if the endometrium is thin it is not suitable for moving on to embryo transfer (ET). We presume at that stage that once ET has crossed 7 or 8mm that further results are on the basis of the embryo. Of these the latest study by Liu., et al. [2] documented a reduction in both clinical pregnancy along with live birth rates at a significant level for every mm decrease below 8mm in preovulatory phase in 24,000 fresh IVF-ET cycles. Similarly, in frozen thawed embryo transfer (FET) cycles with every mm decrease in Endometrial Thickness < 7 mm in > 20,000 FET cycles.

References

      1. Kulvinder Kochar Kaur., et al. “Importance of Chronic Endometritis (CE) in RIF-An update on diagnosis and treatment”. OAJSRD 5 (2019).
      2. Liu KE., et al. “The impact of a thin lining on fresh and frozen thaw IVF outcomes: an analysis of over 40, 000 embryo transfers”. Human Reproduction 10 (2018): 1883-1888.
      3. Isaacs JD Jr., et al. “Endometrial Thickness is a valid monitoring parameter in cycles of ovulation induction with menotropins alone”. Fertility and Sterility 65 (1996): 262-266.
      4. Weissman A., et al. “The detrimental effect of increased Endometrial Thickness on implantation and pregnancy rates and outcomes in an in vitro fertilization program”. Fertility and Sterility 1 (1999): 147-149.
      5. Haas J., et al. “Endometrial compaction (decreased thickness) in response to progesterone results in optimal pregnancy outcome in frozen embryo transfers”. Fertility and Sterility 3 (2019): 503-509.
      6. Labarta E., et al. “Low serum progesterone on the day of embryo transfer is associated with a diminished ongoing pregnancy rate inn oocyte donation cycles after artificial endometrial preparation: a prospective study”. Human Reproduction 12 (2017): 2437-2442.
      7. Kofinas JD., et al. “Serum progesterone levels greater pregnancy than 20 ng/dl [sic]on day of embryo transfer is associated with lower live birth and higher pregnancy rates”. Journal of Assisted Reproduction and Genetics 9 (2015): 1395-1399.
      8. Colombo S., et al. “Significance of endometrial lining decrease after progesterone start in synthetic frozen embryo transfer (FET) cycles”. Fertility and Sterility 5 (2017): e304-e305.
      9. Kulvinder Kochar Kaur., et al. “Autologous Platelet rich plasma (PRP): A Possibility of becoming a revolutionary therapy in the field of Gynaecology and reproductive Endocrinology and Infertility-A Systematic Review”. Progress in Women's Health Care1 (2019): 1-13.
      10. Forman EJ. “The receptive endometrium: the thinner the better?” Fertility and Sterility 3 (2019): 469-470.
Citation: Kulvinder Kochar Kaur., et al. “How Close we have Reached in Overcoming the Limiting Factor in IVF-ET Success Namely the Endometrium”. EC Gynaecology 9.1 (2020): 01-03.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


May Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the May issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before May 25, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.