Mini Review
Volume 11 Issue 9 - 2022
Prominence of the Evolutionary and Personalized Strategy in the Breast Cancer Management: A Junction Between Cancer Cell Genetics and Clinical Oncology
Parvin Mehdipour*
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author: Parvin Mehdipour, Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Received: June 23, 2022 Published: August 22, 2022




Abstract

ATM has the key role in different cancers including breast. The molecular alteration of D1853N polymorphism, accompanied by the IVS 38- 63T>A and IVS38-30A>G alterations in the exon 37 and its 5’-splicing region, played the instructive role in the development of astrocytoma, as three-hit hypothesis. The D1853N polymorphism, is considered as a predisposing factor in a proband affected with primary BC.

The eight-hit event in a breast cancer patient, presented the sequential molecular alterations including the inherited D1853N predisposing factor as the first hit. The cascade of additional molecular alterations include IVS 36-8 T>C as the 2nd hit, V1833M as the 3rd hit and L1888L as the 4th- hit and the complementary somatic variants (IVS 36-46 C>T, L1842L, H1864H, and S1872R). Protein expression of ATM revealed, as a confirmative role is found to be low.

The hits with influential impact on the function of ATM was, also, confirmed by in silico analysis.

The strategic and programmed events of the breast cells are shaped through the multi-developmental processes including the programmed proliferation accompanied by different cascade of events to secure the occurrence of breast carcinoma (BC).

The major focal points of this commentary includes the evolutionary events including Five-hit and Eight-hit hypothetic personalized events in the breast cancer patients.

Key considerations: Major Concerns and the essential step in Cancer Prevention includes: 1) an early detection; 2) Considering the right of the proband’s relatives through the pedigree-based strategy; 3) considering the personalized insight; 4) application of combination of technologies including molecular and single cell-based functional assays.

 

Keywords: Evolution; Personalized; Hit Hypothesis; Breast Cancer; ATM Polymorphism; Predisposing Gene

 

References

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Citation: Parvin Mehdipour. “Prominence of the Evolutionary and Personalized Strategy in the Breast Cancer Management: A Junction Between Cancer Cell Genetics and Clinical Oncology”. EC Gynaecology 11.9 (2022): 46-51.

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