Case Report
Volume 11 Issue 8 - 2022
Arterial Stiffness in Pregnant with Non-Alcoholic Fatty Liver Disease During 4th to 31th Gestational Week Follow-Up: A Case Report of Preterm Birth
Avramovska Maja1, Poposki Vlatko2, Stefan Talev3, Stoilova Snezana4, Mira Mladenovska5, Kosta Sotiroski6, Vesna Shiklovska7 and Avramovski Petar8*
1Department of Obstetrics and Gynecology, Specialist of Obstetrics and Gynecology, Clinical Hospital, Bitola, North Macedonia
2Senior Resident of Epidemiology, Department of Public Health, Bitola, North Macedonia
3Department of Surgery, Specialist of Surgery, Clinical Hospital, Bitola, North Macedonia
4Professor, High Medical School, Department of Medical Statistics, St. Clement of Ohrid University of Bitola, Clinical Hospital, Bitola, North Macedonia
5Diabetologist, Department of Endocrinology, Specialist of internal medicine, Clinical Hospital, Bitola, North Macedonia
6Professor, Faculty of Economics - Prilep, Department of Statistics, St. Clement of Ohrid University of Bitola, Clinical Hospital, Bitola, North Macedonia
7Radiologist, Department of Radiology, Specialist of Radiology, Clinical Hospital, Bitola, North Macedonia
8Associate Professor, Department of Internal Medicine, Primarius, Specialist of Internal Medicine, St. Clement of Ohrid University of Bitola, Clinical Hospital, Bitola, North Macedonia
*Corresponding Author: Avramovski Petar, Associate Professor, Department of Internal Medicine, St. Clement of Ohrid University of Bitola, Clinical Hospital, Bitola, North Macedonia.
Received: July 13, 2022; Published: July 28, 2022


Introduction: There is a strong correlation between nonalcoholic fatty liver disease (NAFLD) and increased pulse wave velocity (PWV) which is in association with hypertensive complication, postpartum hemorrhage and preterm birth. This is a case report of PWV and NAFLD progressive changes, also laboratory markers in pregnant women during a 4th to 31th gestational week (g.w.) follow-up period with preterm delivery.

Case Presentation: We found by ultrasonography (at 4 g.w.) a mild NAFLD according measured hepatorenal index (HRI) = 1.187 and elevated PWV = 6.37 cm/s in 32-year-old pregnant overweight woman [Body mass index (BMI) = 25.6 kg/m2] with accelerated aminotransferases activity, and impaired glucose and lipid metabolism. The ultrasound examination performed at 31 g.w. found increased BMI by 16%, PWV by 6.4% and HRI by 11.6%. Increased systolic/diastolic blood pressure (10.1%/22.7%) and impaired metabolism of insulin, glucose and lipid were detected, too. The baby boy was born preterm, with normal 5-min and 10-min Apgar score, in 36 g.w.

Conclusion: Increased PWV, NAFLD, impaired metabolism of glucose and lipids, high BMI, insulin resistance and gestational diabetes are risk factors for the premature delivery. Early detection of NAFLD and PWV rise, blood pressure, lipid and glucose metabolism will improve the mother's and newborn's health, and will also contribute to on term deliveries.

Keywords: Non-Alcoholic Fatty Liver Disease; Pulse Wave Velocity; Hepatorenal Index; Preterm Birth; Arterial Stiffness


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Citation: Avramovski Petar., et al. “Arterial Stiffness in Pregnant with Non-Alcoholic Fatty Liver Disease During 4th to 31th Gestational Week Follow-Up: A Case Report of Preterm Birth”. EC Gynaecology 11.8 (2022): 37-43.

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