Short Communication
Volume 10 Issue 6 - 2021
Advantage of Utilizing Highly Purified Human Menotropin (Possessing HCG Activity) Over Plain Recombinant FSH in High Responders Presenting with AMH ≥ 5 ng/ml Undergoing IVF/ICSI-A Short Communication
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Ex-Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Noel Taboada Lugo, Medical Doctor, Family Medicine Specialist, Clinical Genetics Specialist, Master’s Degree in Comprehensive Child Health, Associate Professor of the Medical University of Villa Clara, Cuba.
Received: April 15, 2021; Published: May 05, 2021




Abstract

It is well understood that patients with Polycystic ovary syndrome (PCOS) possessing high anti-Mullerian hormone (AMH) amount have a higher risk of getting ovarian hyperstimulation when attempting controlled ovarian hyperstimulation (COS) in cases undergoing ‘in vitro fertilization’ (IVF). Although with utilization of gonadotropin releasing hormone (GnRH) agonists for trigger for oocyte maturation in Gn RH antagonist cycles helps in avoiding Ovarian hyperstimulation Syndrome (OHSS), the ideal stimulation protocol is further required to be evaluated so that we can optimize the best pregnancy rates, live birth rates (LBR), avoid preterm or other pregnancy losses secondary to the stimulation protocol, here Witz., et al’s multicenter study points that utilizing only HPhMG (possessing HCG activity like menopur or humog against recombinant follicle stimulating hormone (FSH)) alone might yield the best results with least complications.

Keywords: PCOS; High AMH; HPhMG; OHSS

References

  1. Orvieto R. “hMG, versus recombinant FSH in ovarian stimulation for IVF: does the source of LH matter?”. Reproductive BioMedicine Online 6 (2019): 1001-1006.
  2. Andersen AN., et al. “Clinical outcomes following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor blind controlled trial”. Human Reproduction 12 (2006): 3217-27.
  3. Devroey P., et al. “A randomized assessor blind controlled trial comparing highly purified hMG and recombinant FSH in a GnRH antagonist cycle with compulsory single blastocyst transfer”. Fertility and Sterility 3 (2012): 561-571.
  4. Arce JC., et al. “The rate of high ovarian response in women identified at risk b y a high serum AMH serum level is influenced by the type of gonadotropin”. Gynecological Endocrinology 6 (2014): 444-450.
  5. Kulvinder Kochar Kaur and Bhatia SK. “Role of LH Activity in Poor Responders AS HCG Activity with Advantage of Implantation with HCG”. Poster presented in COGI Congress in Singapore (2012).
  6. Witz CA., et al. “Menopur in GnRH antagonist cycles with single embryo transfer-High responders (MEGASET HR) trial Group: A randomized assessor blind controlled trial comparing highly purified human menotropin (HPhMG) and recombinant follicle stimulating hormone (FSH) in High responders undergoing ICSI”. Fertility and Sterility 2 (2020): 321-330.
  7. Engmann L., et al. “The use of gonadotropin releasing hormone (GnRH) agonist to induce oocyte maturation after cotreatment with GnRH antagonist in high risk patients undergoing in vitro fertilization prevents Ovarian hyperstimulation Syndrome: a prospective randomized controlled study”. Fertility and Sterility 1 (2008): 84-91.
  8. Kalra S., et al. “Ovarian stimulation and low birth weight in newborns conceived through in vitro fertilization”. Obstetrics and Gynaecology 4 (2011): 863-871.
  9. Molinaro T. “Taking the ‘’art’’ out of ‘’ART’’”. Fertility and Sterility 2 (2020): 263-264.
Citation: Kulvinder Kochar Kaur., et al. “Advantage of Utilizing Highly Purified Human Menotropin (Possessing HCG Activity) Over Plain Recombinant FSH in High Responders Presenting with AMH ≥ 5 ng/ml Undergoing IVF/ICSI-A Short Communication”. EC Gynaecology 10.6 (2020): 19-21.

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