Research Article
Volume 10 Issue 5 - 2021
Maternal and Fetal Outcome in Dual Gestational Endocrinopathy
Veena M Vernekar1*, Shruti K2, Sumayya Sana2, Razia Begam1, Prashanth FG1, Pooja P1, Chandana HS1, Ananya I1 and Sreelatha S3
1Junior Resident, Department of OBG, ESICMC PGIMSR, Rajajinagar, Bengaluru, India
2Senior Resident, Department of OBG, ESICMC PGIMSR, Rajajinagar, Bengaluru, India
3Professor, Department of OBG, ESICMC PGIMSR, Rajajinagar, Bengaluru, India
*Corresponding Author: Veena M Vernekar, Junior Resident, Department of OBG, ESICMC PGIMSR, Rajajinagar, Bengaluru, India.
Received: March 15, 2021; Published: April 06, 2021




Abstract

Background: Hypothyroidism and diabetes are the endocrine disorders commonly observed in pregnancy and each has been associated with adverse maternal and foetal outcomes. As there is a very high prevalence of hypothyroidism among GDM patients, this study is aimed at determining the prevalence of hypothyroidism among GDM patients and the maternal outcome and fetal outcome in pregnant women with dual endocrinopathy.

Aims and Objectives:

  1. To determine the proportion of hypothyroidism in pregnant with gestational diabetes mellitus.
  2. To assess the maternal and foetal outcome in antenatal patients with gestational diabetes mellitus and hypothyroidism.

Methodology: This is a descriptive study conducted in department of OBG, ESIC-PGIMSR Bangalore between January 2020 to June 2020. All women attending antenatal OPD with gestational diabetes mellitus and thyroid dysfunction are followed up, and the maternal and foetal outcome evaluated.

Results: In our study the prevalence of hypothyroidism in patients with GDM is found to be 37.5%. Dual endocrinopathy is associated with increased risk of preeclampsia (27.3%) and risk for cesearean section (64.4%) and increased neonatal morbidity.

Conclusion: There is a high prevalence of hypothyroidism among patients with GDM and the dual endocrinopathy is associated with adverse maternal and foetal outcome. Hence pregnant women diagnosed with one of these endocrinopathies should be screened for the other.

 

Keywords: Gestational Diabetes Mellitus; Thyroid Dysfunction; Dual Endocrinopathy; Preeclampsia; Foetal Outcome; Caesarean Section

References

  1. Tirosh D., et al. “Hypothyroidism and diabetes mellitus - a risky dual gestational endocrinopathy”. Peer Journal 1 (2013): e52.
  2. Shahbazian H., et al. “Evaluation of thyroid dysfunction in pregnant women with gestational and pre-gestational diabetes”. Pakistan Journal of Medical Sciences 29 (2013): 638-641.
  3. Kadiyala R., et al. “Thyroid dysfunction in patients with diabetes: clinical implications and screening strategies”. International Journal of Clinical Practice 64 (2010): 1130-1139.
  4. Prasad DB., et al. “Relationship of gestational diabetes mellitus with hypothyroidism in pregnancy”. Scholars Journal of Applied Medical Sciences 7 (2015): 2719-2723.
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  7. Divakar H., et al. “Dual Endocrinopathy- The nexus between hyperglycemia (gestational diabetes) and hypothyroidism among pregnant women in India”. Journal of Evidence Based Medicine and Healthcare61 (2017): 3658-3661.
  8. Parveen H., et al. “Association of Hypothyroidism in Pregnant Women with Hyperglycaemia”. International Journal of Health Sciences and Research9 (2019): 325-329.
  9. Yang J., et al. “Fetal and neonatal outcomes of diabetic pregnancies”. Obstetrics and Gynecology 108 (2006): 644-650.
  10. Feely J and Isles TE. “Screening for thyroid dysfunction in diabetics”. British Medical Journal 1 (1979): 1678.
  11. Sahu MT., et al. “Overt and subclinical thyroid dysfunction among Indian pregnant women and its effect on maternal and fetal outcome”. Archives of Gynecology and Obstetrics 281 (2010): 215-220.
  12. Wiznitzer A., et al. “Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study”. American Journal of Obstetrics and Gynecology 201 (2009): 482.
  13. Amudha P., et al. “Implications of combined endocrinopathy of diabetes mellitus and hypothyroidism on pregnancy”. International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6 (2017): 266-270.
Citation: Veena M Vernekar., et al. “Maternal and Fetal Outcome in Dual Gestational Endocrinopathy”. EC Gynaecology 10.5 (2020): 16-23.

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