Research Article
Volume 10 Issue 4 - 2021
Serum FSH Levels during IVF Cycles: A New Paradigm for Clinical Management of Ovarian Stimulation
Barry Perlman1*, Kulak D1,2,3, Oh C4 and McGovern PG1,2
1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women’s Health, Rutgers New Jersey Medical School, Newark, NJ, USA
2University Reproductive Associates, Hasbrouck Heights, NJ, USA
3Genesis Fertility, Brooklyn, NY, USA
4New York University School of Medicine, New York, NY, USA
*Corresponding Author: Barry Perlman, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics, Gynecology and Women’s Health, Rutgers New Jersey Medical School, Newark, NJ, USA.
Received: January 04, 2021; Published: March 10, 2021




Abstract

Exogenous FSH is the catalyst controlling controlled ovarian stimulation (COS), with high dosing being associated with negative outcomes. A retrospective cohort study of COS cycles was performed to determine the effect dosing and BMI has on serum FSH levels and to determine if serum FSH levels are associated with changes in live birth rates. In this study, 397 GnRH suppressive cycles were analyzed. Serum FSH levels were measured every 48-72 hours throughout COS and the change (delta) in serum FSH levels from baseline was calculated. Elevated day 3 serum FSH levels were significantly associated with decreased live births (OR: 0.86; 95%CI: 0.78 - 0.94, p = 0.002), while antral follicle count (OR: 01.077; 95%CI: 1.028 - 1.128, p = 0.002), number of oocytes retrieved (OR: 1.053; 95%CI: 1.002 - 1.107, p = 0.04), and number of embryos transferred (OR: 1.292; 95%CI: 1.284 - 1.301, p < 0.001) were significantly associated with an increased birth rate. Elevated delta FSH and maximum serum FSH significantly (p < 0.001) correlated with a decrease in live births. Increased BMI significantly reduced serum FSH levels, suggesting BMI should be considered when calculating FSH dose. Overall, maximum serum FSH and elevated serum delta FSH levels were associated with lower live birth rates supporting a rationale for measuring serum FSH during COS.

Keywords: IVF; Serum FSH; BMI; Live Birth Rate

References

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Citation: Barry Perlman., et al. “Serum FSH Levels during IVF Cycles: A New Paradigm for Clinical Management of Ovarian Stimulation”. EC Gynaecology 10.4 (2020): 13-21.

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