Abstract
Currently reproductive function of men is usually monitored by semen and hormones analysis, which are insensitive and highly variable indicators of testicular functions. Testicular protein, glycogen, sialic acid and cholesterol play an important role in spermatogenesis and fertilizing capacity of spermatozoa. Therefore, measuring these biomarkers provides insight into testicular response to occupational and environmental exposures. This study has developed a predictive tool to measure altered testicular functions following exposure to occupational and environmental exposure. It will allow the physicians to monitor the reproductive capacity of patients and help them to better counsels their patients about their fertility.
Keywords: Testicular Dysfunction Biomarkers; Hormones; Semen; Fertility
References
- Kayode OT., et al. “Alcoholic bitters modulates sex hormones and some biochemical parameters of testicular function in male Wistar rats”. F1000 Research1838 (2018): 1838.
- Kayode OT., et al. “Monosodium glutamate (MSG)-induced male reproductive dysfunction: A mini review”. Toxics1 (2020): 7.
- Steger K and Weidner W. “Anatomy of the male reproductive system”. In Practical Urology: Essential Principles and Practice Springer, London (2011): 57-68.
- Olaolu TD., et al. “Effect of alcohol infusion of Cissus populnea root on testicular function and serum hormone of male Wistar rats”. Asian Pacific Journal of Reproduction 3 (2018): 117.
- McKay AC and Sharma S. “Anatomy, seminal vesicle”. Statpearls. Treasure Island (FL) (2018).
- Baskaran S., et al. “Exosomes of male reproduction”. In Advances in Clinical Chemistry Elsevier 95 (2020): 149-163.
- Pereira GR., et al. “Effect of scrotal insulation on sperm quality and seminal plasma proteome of Brangus bulls”. Theriogenology 144 (2020): 194-203.
- Kowaltowski A and Abdulkader F. “How Metabolism Works. In Where Does All That Food Go?” Copernicus, Cham (2020): 5-15.
- Vandenberg LN., et al. “Hormones and endocrine-disrupting chemicals: low-dose effects and nonmonotonic dose responses”. Endocrine Reviews 3 (2012): 378-455.
- Van Casteren JI., et al. “Development of time-resolved immunofluorometric assays for rat follicle-stimulating hormone and luteinizing hormone and application on sera of cycling rats”. Biology of Reproduction4 (2000): 886-894.
- Kayode OT., et al. “Ketogenic diet improves and restores redox status and biochemical indices in monosodium glutamate-induced rat testicular toxicity”. Biomedicine and Pharmacotherapy 127 (2020): 110227.
- Hunter I., et al. “Tissue control of androgen action: The ups and downs of androgen receptor expression”. Molecular and Cellular Endocrinology 465 (2018): 27-35.
- Ahmed T., et al. “Is Testosterone Replacement Safe in Men with Cardiovascular Disease?”. Cureus3 (2020).
- Kanakis GA., et al. “Measuring testosterone in women and men”. Maturitas 125 (2019): 41-44.
- Yassin A., et al. “Testosterone, testosterone therapy and prostate cancer”. The Aging Male 4 (2019): 219-227.
- Bhasin S., et al. “Testosterone therapy in men with hypogonadism: an Endocrine Society clinical practice guideline”. The Journal of Clinical Endocrinology and Metabolism 5 (2018): 1715-1744.
- De Souza GL and Hallak J. “Anabolic steroids and male infertility: a comprehensive review”. BJU International 11 (2011): 1860-1865.
- Allan CM., et al. “A Novel Transgenic Model to Characterize the Specific Effects of Follicle-Stimulating Hormone on Gonadal Physiology in the Absence of Luteinizing Hormone Actions”. Endocrinology 6 (2001): 2213-2220.
- Liu XM., et al. “FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca2+/CREB pathway”. Aging Cell3 (2015): 409-420.
- Olaolu TD and Rotimi DE. “Evaluation of the effect of Cissus populnea aqueous root infusion on some testicular function indices and serum hormones of male rats”. Nigerian Journal of Biotechnology1 (2017): 105-116.
- Shi JF., et al. “Characterization of cholesterol metabolism in Sertoli cells and spermatogenesis”. Molecular Medicine Reports1 (2018): 705-713.
- Ando H. “Luteinizing Hormone. In Handbook of Hormones”. Academic Press (2016): 104-114.
- Schoeller EL., et al. “The effects of type 1 diabetes on the hypothalamic, pituitary and testes axis”. Cell and Tissue Research3 (2012): 839-847.
- Haroun HS. “Reproductive cycles in females”. MOJ Womens Health2 (2016): 62-64.
- Corradi PF., et al. “Physiology of the hypothalamic pituitary gonadal axis in the male”. Urologic Clinics2 (2016): 151-162.
- Tsutsui K., et al. “Gonadotropin-inhibitory hormone (GnIH): discovery, progress and prospect”. General and Comparative Endocrinology3 (2012): 305-314.
- Maroto-Morales A., et al. “Current status and potential of morphometric sperm analysis”. Asian Journal of Andrology6 (2016): 863.
- Yakubu MT. “Effect of a 60‐Day Oral Gavage of a Crude Alkaloid Extract From Chromolaena odorata Leaves on Hormonal and Spermatogenic Indices of Male Rats”. Journal of Andrology6 (2012): 1199-1207.
- Patil SA and Patil SB. “Toxicological studies of Momordica charantia Linn". Seed extracts in male mice”. The International Journal of Morphology 4 (2011): 1212-1218.
Journal Menu
PubMed Indexed Article
EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
PMID: 31143884 [PubMed]
PMCID: PMC6536005
EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.
PMID: 31565701 [PubMed]
PMCID: PMC6764777
EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.
PMID: 27747317 [PubMed]
PMCID: PMC5065347
EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?
PMID: 31460519 [PubMed]
PMCID: PMC6711478
EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?
PMID: 30215059 [PubMed]
PMCID: PMC6133253
EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.
PMID: 30417173 [PubMed]
PMCID: PMC6226033
EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.
PMID: 30264037 [PubMed]
PMCID: PMC6155992
EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.
PMID: 30198026 [PubMed]
PMCID: PMC6124505
EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.
PMID: 30294723 [PubMed]
PMCID: PMC6169793
EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs
PMID: 29285526 [PubMed]
PMCID: PMC5743211
EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique
PMID: 29911204 [PubMed]
PMCID: PMC5999047
EC Microbiology
Macrophages and the Viral Dissemination Super Highway
PMID: 26949751 [PubMed]
PMCID: PMC4774560
EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.
PMID: 27390782 [PubMed]
PMCID: PMC4933318
EC Microbiology
Reactive Oxygen Species in HIV Infection
PMID: 28580453 [PubMed]
PMCID: PMC5450819
EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population
PMID: 26280024 [PubMed]
PMCID: PMC4533840
EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis
PMID: 28066845 [PubMed]
PMCID: PMC5214344
EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology
PMID: 28936490 [PubMed]
PMCID: PMC5604476
EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia
PMID: 28713879 [PubMed]
PMCID: PMC5510658
EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature
PMID: 28133641 [PubMed]
PMCID: PMC5267489
EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling
PMID: 29333536 [PubMed]
PMCID: PMC5766278
EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.
PMID: 31032493 [PubMed]
PMCID: PMC6483108
EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.
PMID: 30957099 [PubMed]
PMCID: PMC6448571
EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.
PMID: 30101228 [PubMed]
PMCID: PMC6086333
EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.
PMID: 31080964 [PubMed]
PMCID: PMC6508883
EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.
PMID: 31093608 [PubMed]
PMCID: PMC6513001
EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.
PMID: 31552397 [PubMed]
PMCID: PMC6758937
EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.
PMID: 31681909 [PubMed]
PMCID: PMC6824723
EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.
PMID: 31681910 [PubMed]
PMCID: PMC6824726
EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.
PMID: 31528859 [PubMed]
PMCID: PMC6746603
EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?
PMID: 31276119 [PubMed]
PMCID: PMC6604646
EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.
PMID: 31406965 [PubMed]
PMCID: PMC6690616
EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.
PMID: 31517314 [PubMed]
PMCID: PMC6741290
EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.
PMID: 31633124 [PubMed]
PMCID: PMC6800226
EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.
PMID: 29662969 [PubMed]
PMCID: PMC5898812
EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.
PMID: 30215058 [PubMed]
PMCID: PMC6133268
News and Events
March Issue Release
We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the March issue of respective journals and the latest articles can be viewed on the current issue pages.
Submission Deadline for Upcoming Issue
ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before April 03, 2023.
Certificate of Publication
ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.
Best Article of the Issue
Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.
Certifying for Review
ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.
Latest Articles
The latest articles will be updated immediately on the articles in press page of the respective journals.