Review Article
Volume 9 Issue 11 - 2020
Markers of Connective Tissue Dysfunction in the Aspect of Surgical Treatment of Pelvic Organ Prolapse
Bezhenar VF, Derii EK, Ivanov OA, Azhimova Sh M and Palastin PM*
Federal State Budgetary Educational Institution of Higher Education “Academician I. P. Pavlov First St. Petersburg State Medical University” of the Ministry of Healthcare of the Russion Federation, Department of Obstetrics, Gynecology and Neonatology, St.-Petersburg, Russia
*Corresponding Author: Palastin PM, Federal State Budgetary Educational Institution of Higher Education “Academician I. P. Pavlov First St. Petersburg State Medical University” of the Ministry of Healthcare of the Russion Federation, Department of Obstetrics, Gynecology and Neonatology, St.-Petersburg, Russia.
Received: June 04, 2020; Published: October 19, 2020




Abstract

Pelvic organ prolapse (POP) is a serious and relevant urogynecological problem. According to modern data, about 47% of women of working age suffer from this condition [1]. Due to the lack of established criteria for choosing a surgical correction method, recurrence of pelvic organ prolapse and stress urinary incontinence after pelvic floor surgery with native tissue repair vary between 30 - 58% [2] and with mesh implants - 6,9% [3]. Choosing a method of surgical treatment, it is necessary to take into account medical history, clinical, instrumental, genetic, biochemical, morphological and immunohistochemical examinations. Combination of various methods is used to identify pelvic organ prolapse markers in each clinical case. The choice of surgical treatment is made after obtaining results on the state of the pelvic floor.

Key words: Markers; Gene Expression; Pelvic Organ Prolapse; Predictors

References

  1. Krasnopolsky VI., et al. “Combined treatment of patients with internal genital lowering and falling out and urinary incontinence using anti-stress technologies”. Physician's Allowance (2003): 41.
  2. Olsen AL., et al. “Epidemiology of surgically managed pelvic organ prolapse and urinary incontinence”. Obstetrics and Gynecology 4 (1997): 501-506.
  3. Whiteside JL., et al. “Risk factors for prolapse recurrence after vaginal repair”. American Journal of Obstetrics and Gynecology 5 (2004):1533-1538.
  4. Yashchuk AG., et al. “Clinical and genetic parallels between connective tissue disease, genital prolapse and joint hypermobility syndrome”. Gynecology, Obstetrics and Perinatology4 (2018): 31-35.
  5. Gutikova LV. “Genital prolapse: the current state of the problem”. Journal of the Grodno State Medical University37 (2012): 86-89.
  6. Beer M and AKuhn. “Surgical techniques for vault prolapse: a review of literature”. European Journal of Obstetrics and Gynecology and Reproductive Biology 2 (2005): 144-155.
  7. Bezhenar VF., et al. “Complications arising from the surgical treatment of pelvic organ prolapse using the Prolift system”. Journal of Obstetrics and Women's Diseases5 (2009): 25-26.
  8. Kadurina TI and Abbakumova LN. “Connective tissue dysplasia: the path to diagnosis”. Bulletin of Iv GMA3 (2014): 5-11.
  9. S Kurt E., et al. “Can striae be used as a marker for the prediction of pelvic organ prolapse?”. European Journal of Obstetrics and Gynecology and Reproductive Biology 180 (2014): 116-119.
  10. Van Raalte H and Egorov V. “Tactile Imaging Markers to Characterize Female Pelvic Floor Conditions”. Open Journal of Obstetrics and Gynecology 9 (2015): 505-515.
  11. Egorov V., et al. “Biomechanical Mapping of the Female Pelvic Floor: Prolapse versus Normal Conditions”. Open Journal of Obstetrics and Gynecology 10 (2018): 900-924.
  12. Apolikhina IA., et al. “Pelvic floor dysfunction: modern principles of diagnosis and treatment. Effective pharmacotherapy”. Obstetrics and Gynecology 22 (2016): 16-23.
  13. Patcharatrakul T and Rao SSC. “Update on the Pathophysiology and Management of Anorectal Disorders”. Gut Liver 4 (2018): 375-384.
  14. Ziganshin AM., et al. “Method of computer vaginotensometric study of the force of contractions of the obturator vaginal muscle”. Basic Research 5-2 (2013): 283-285.
  15. Lukyanenko NS., et al. “Markers of impaired fibrillogenesis in children with different variants of the course of pyelonephritis”. Kidneys2 (2018): 100-106.
  16. Ilyina UJ., et al. “The significance of biochemical markers of collagen breakdown in predicting the recurrence of genital prolapse in women with connective tissue dysplasia”. Bulletin of the Russian State Medical University 1 (2012): 44-46.
  17. Pareishvili VV., et al. “Study of the content of the N-terminal propeptide of type III procollagen for the diagnosis of undifferentiated connective tissue dysplasia in pregnant women”. Tauride Medical and Biological Bulletin1 (2018): 110-115.
  18. Rusina EI., et al. “Features of polymorphism of the MMP1, MMP3, PAI1 genes in patients with pelvic organ prolapse and stress urinary incontinence”. Obstetrics and Gynecology 9 (2014): 63-68.
  19. Ghersel FR., et al. “Assessment of Metalloproteinase Matrix 9 (MMP9) Gene Polymorphisms Risk Factors for Pelvic Organ Prolapse in the Brazilian Population”. Revista Brasileira de Ginecologia e Obstetrícia 3 (2019): 164-169.
  20. Dubinskaya ED., et al. “NAT2 gene polymorphism as a predictor of relapse after surgical treatment of pelvic organ prolapse”. Bulletin of the Russian Academy of Medical Sciences6 (2017): 466-472.
  21. Cartwright R., et al. “Systematic review and metaanalysis of genetic association studies of urinary symptoms and prolapse in women”. American Journal of Obstetrics and Gynecology 2 (2015): 199.e1-199.e24.
  22. Khadzhieva MB., et al. “Verification of the Chromosome Region 9q21 Association with Pelvic Organ Prolapse Using RegulomeDB Annotations”. BioMed Research International (2015): 837904.
  23. Rao S., et al. “Exome Sequencing Identifies a Novel Gene, WNK1, for Susceptibility to Pelvic Organ Prolapse (POP)”. PLoS One3 (2015): e0119482.
  24. Yılmaz N., et al. “HOXA11 and MMP2 gene expression in uterosacral ligaments of women with pelvic organ prolapsed”. Journal of The Turkish-German Gynecological Association 2 (2014): 104-108.
  25. Liu C., et al. “Collagen metabolic disorder induced by oxidative stress in human uterosacral ligament derived fibroblasts: A possible pathophysiological mechanism in pelvic organ prolapsed”. Molecular Medicine Reports4 (2016): 2999-3008.
  26. Jakus IA., et al. “Immunohistochemical expression of hypoxia-inducible factor-1α in stromal cells of vaginal tissue in post-menopausal women with pelvic organ prolapsed”. Indian Journal of Medical Research 8 (2017): 63-67.
  27. Fang G., et al. “Oxidative status of cardinal ligament in pelvic organ prolapsed”. Experimental and Therapeutic Medicine 4 (2018): 3293-3302.
  28. Lu Y., et al. “Correlations between Mitofusin 2 Expression in Fibroblasts and Pelvic Organ Prolapse: An In vitro Study”. Chinese Medical Journal 24 (2017): 2951-2959.
  29. Hong S., et al. “The role of GPX1 in the pathogenesis of female pelvic organ prolapsed”. PLoS One8 (2017): e0181896.
  30. Sun ZJ., et al. “Proteomic Analysis of the Uterosacral Ligament in Postmenopausal Women with and without Pelvic Organ Prolapse”. Chinese Medical Journal 23 (2015): 3191-3196.
  31. Zhao B., et al. “Interferon-γ and its pathway-associated gene expression in the vaginal tissue of premenopausal females with pelvic organ prolapsed”. Experimental and Therapeutic Medicine 4 (2014): 1145-1149.
  32. Vetuschi A., et al. “Changes in Muscularis Propria of Anterior Vaginal Wall in Women with Pelvic Organ Prolapse”. European Journal of Histochemistry 1 (2016): 2604.
  33. Zhao X., et al. “Hypoxia Induces Apoptosis through HIF-1α Signaling Pathway in Human Uterosacral Ligaments of Pelvic Organ Prolapse”. BioMed Research International (2017): 8316094.
  34. Zhao X., et al. “Hypoxia-Inducible Factor 1-α (HIF-1α) Induces Apoptosis of Human Uterosacral Ligament Fibroblasts Through the Death Receptor and Mitochondrial Pathways”. Medical Science Monitor 24 (2018): 8722-8733.
  35. Allen-Brady K., et al. “Evidence for Pelvic Organ Prolapse Predisposition Genes on Chromosomes 10 and 17”. American Journal of Obstetrics and Gynecology 6 (2015): 771.e1-771.e7.
Citation: Palastin PM., et al. “Markers of Connective Tissue Dysfunction in the Aspect of Surgical Treatment of Pelvic Organ Prolapse”. EC Gynaecology 9.11 (2020): 45-50.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


September Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the September issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before October 14, 2022.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.