Mini Review
Volume 9 Issue 9 - 2020
PhotoBioModulation: Promising Supplement in Women’s Health
Arne Grinsted1* and Maja Grinsted Hillegass2
1Founder and President of PowerMedic ApS, Denmark and PowerMedic Lasers, Inc, USA
2Sales Manager, PowerMedic Lasers, Inc, USA
*Corresponding Author: Arne Grinsted, Founder and President of PowerMedic ApS, Denmark and PowerMedic Lasers, Inc, USA.
Received: May 17, 2020; Published: August 14, 2020


PhotoBioModulation (PBM) is widely recognized as a fast and effective way to increasing energy (ATP) in the cells and thereby strengthening the mitochondria [29,30].

PhotoBioModulation was first discovered in 1967 and a large amount of research has since documented its benefits for a wide range of applications, including acute injuries, neck pain, arthritis, epicondylitis, wound healing, and much more [29,31].

In recent years, a number of clinics have also successfully been using PBM to treat women facing fertility issues, to help improve their chances of conception [1]. The article “PhotoBioModulation for Infertility”, published in EC Gynaecology 8.9 (2019): 875-879, concluded that “PBM could be a viable choice as a natural, non-invasive addition to other methods of ART”.

In addition to infertility, PBM also appears to be beneficial in other areas related to reproductive health, including endometriosis and Polycystic Ovary Syndrome (PCOS), as well as other women’s health issues, such as carpal tunnel syndrome, fibromyalgia, and some autoimmune diseases.

Our conclusion is that PBM could be a valuable option as a natural, non-invasive supplement in the treatment of a wide range of women’s health issues.

Keywords: PhotoBioModulation (PBM); Low Level Laser Therapy (LLLT); Laser Therapy; Cold Laser Therapy; Reproductive Health; Women’s Health


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  6. Fujii S., et al. “Proximal priority treatment using the neck irradiator for adjunctive treatment of female infertility” (2007).
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  11. Firestone R., et al. “The effects of low-level light exposure on sperm motion characteristics and DNAdamage” (2013).
  12. Salman Yazdi R., et al. “Effect of 830 nm diode laser irradiation on human sperm motility” (2014).
  13. Frangez H., et al. “Photomodulation with light emitting diodes improves sperm motility in men with asthenozoospermia” (2014).
  14. Sato H. “The effects of laser light on sperm motility and velocity In vitro” (1984).
  15. Cohen N and Lubart R. “Light irradiation of mouse spermatozoa: Stimulation of in vitro fertilization andcalcium signals”. Photochemistry and Photobiology 3 (1998): 407-413.
  16. Ocaña-Quero J., et al. “Biological effects of helium-neon (He-Ne) laser irradiation on acrosome reaction in bull sperm cells”. Journal of Photochemistry and Photobiology B: Biology3 (1997): 294-298.
  17. Montag M., et al. “Laser induced immobilization and plasma membrane permeabilization in human spermatozoa” (2000).
  18. Corral-Baques M., et al. “Effect of 655-nm diode laser on dog sperm motility” (2005).
  19. Corral-Baques M., et al. “Effect of 655-nm laser at different powers on dog sperm motility parameter” (2006).
  20. Corrral-Baqués M., et al. “The effect of low-level laser irradiation on dog spermatozoa motility is dependent on laser output power” (2009).
  21. Bianchi-Alves M., et al. “17 testicular histopathological characteristics of rams treated with low-level laser therapy: preliminary results” (2013).
  22. Sergey Vladimirovich Moskvin and Oleg Ivanovich Apolikhin. “Effectiveness of low level laser therapy for treating male infertility” (2018).
  23. Schoolcraft W., et al. “Paving the way for a gold standard of care for infertility treatment: improving outcomes through standardization of laboratory procedures” (2017).
  24. American Society for Reproductive Medicine: “Assisted Reproductive Technologies (booklet)” (2018).
  25. Koli S. “12 Mind-blowing Stats Everyone Should Know About Infertility" (2017).
  26. Kincaid E. “The success rate of ‘test tube babies’ are nowhere near what people think” (2015).
  27. SCRC Contributor (Southern California Reproductive Center). “How Long Does IVF Take? An Overview of the IVF Process” (2016).
  28. Gurevich R. “The Chances for IVF Pregnancy Success”. (very well family) (2018).
  29. Hamblin M. “Mechanisms of Low Level Light Therapy” (2008).
  30. Hamblin M. “Mechanisms and Mitochondrial Redox Signaling in Photobiomodulation” (2017).
  31. Chow RT., et al. “Efficacy of low-level laser therapy in the management of neck pain: Efficacy of low- level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials”. Lancet 374.9705 (2009): 1897-1908.
  32. Thabet AAE., et al. “Effect of Pulsed High-Intensity Laser Therapy on Pain Adhesions, and Quality of Life inWomen Having Endometriosis: A Randomized Controlled Trial”. Photobiomodulation, Photomedicine, and Laser Surgery 7 (2018): 363-369.
  33. Alves ED., et al. “Photobiomodulation can improve ovarian activity in polycystic ovary syndrome- induced rats” (2019).
  34. Elshamy Fayiz F., et al. “Effectiveness of Laser Acupoints on Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial”. Journal of Lasers in Medical Sciences 2 (2018):113-120.
  35. Fusakul Y., et al. “Low-level laser therapy with a wrist splint to treat carpal tunnel syndrome: a double blinded randomized controlled trial” (2014).
  36. Yeh S., et al. “Low-Level Laser Therapy for Fibromyalgia: A Systematic Review and Meta-Analysis” (2019).
  37. Alves AC., et al. “Low -level laser therapy in different stages of rheumatoid arthritis: a histological study” (2013).
  38. Office on Women’s Health: “Endometriosis” (2019).
  39. Office on Women’s Health: “Polycystic Ovary Syndrome” (2019).
  40. Office on Women’s Health: “Carpal tunnel syndrome” (2019).
  41. Office on Women’s Health: “Fibromyalgia” (2019).
  42. Office on Women’s Health: Autoimmune diseases” (2019).
Citation: Arne Grinsted and Maja Grinsted Hillegass. “PhotoBioModulation: Promising Supplement in Women’s Health”. EC Gynaecology 9.9 (2020): 67-71.

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