Short Communication
Volume 9 Issue 9 - 2020
Significance of Thyroid Peroxidase Antibodies in Cases of Recurrent Pregnancy Loss in Patients who are Euthyroid-A Short Communication
Kulvinder Kochar Kaur1*, Gautam Allahbadia2 and Mandeep Singh3
1Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India
2Scientific Director, Rotunda-A Centre for Human Reproduction, Mumbai, India
3Consultant Neurologist, Swami Satyanand Hospital, Jalandhar, Punjab, India
*Corresponding Author: Kulvinder Kochar Kaur, Scientific Director, DR Kulvinder Kaur Centre for Human Reproduction, Jalandhar, Punjab, India.
Received: June 30, 2020; Published: August 05, 2020


Recurrent pregnancy loss (RPL) is really a depressing problem. Random chromosomal alterations numerically like trisomy, monosomy, as w ell as polyploidy are the commonest reasons of miscarriage during the 1st 10 weeks of gestation age (GA), that literally are responsible for 50% of cases [1]. Following exclusion of these explained miscarriages, RPL correlates with endocrinopathies, immunological, anatomical as well as inherited genetic causes [2].


  1. Stephenson MD., et al. “Cytogenetic analysis of miscarriages from couples with Recurrent Miscarriage: a case control study”. Human Reproduction 17 (2002): 446-451.
  2. Stephenson MD. “Frequency of factors associated with habitual abortion in 197 couples”. Fertility and Sterility 66 (1996): 24-29.
  3. Krassas GE. “Thyroid disease and female reproduction”. Fertility and Sterility 74 (2000): 1063-1070.
  4. De Escobar GM., et al. “Maternal Thyroid Hormones early in pregnancy and fetal brain development”. Best Practice and Research Clinical Endocrinology and Metabolism 18 (2004): 225-248.
  5. Stagnaro Green., et al. “Detection of at risk pregnancy by means of highly sensitive assays for thyroid autoantibodies”. The Journal of the American Medical Association 264 (1990): 1422-1425.
  6. Taylor PN., et al. “TSH levels and risk of Miscarriage in women with long term levothyroxine: a community based study”. The Journal of Clinical Endocrinology and Metabolism 99 (2014): 3895-3902.
  7. Alexander EK., et al. “2017 Guidelines of the per American Thyroid Association for the diagnosis and management of Thyroid disease during pregnancy and postpartum”. Thyroid 27 (2017): 315-389.
  8. American Society of Reproductive Medicine. “Evaluation and treatment of Recurrent pregnancy loss: a committee opinion”. Fertility and Sterility 98 (2012): 1103-1111.
  9. Bender Atik R., et al. “ESHRE Guidelines: Recurrent pregnancy loss”. Human Reproduction Open (2018).
  10. Royal College of Obstetricians and Gynaecologist. Recurrent Miscarriage, Investigation and treatment of Couples(Green –top Guideline No.17). 3RD edition. London: RCOG (2011).
  11. Dong AC., et al. “Subclinical hypothyroidism and thyroid autoimmunity in Recurrent pregnancy loss: a systematic review and meta-analysis”. Fertility and Sterility 3 (2020): 587-600.
  12. Rotondi M., et al. “Management of Subclinical hypothyroidism in pregnancy: a comment from the Italian Society of endocrinology and Italian Thyroid Association to the 2017 American Thyroid Association Guideline-‘’The Italian Way’’. Thyroid 28 (2018): 551-555.
  13. Dhillon Smith RK., et al. “Levothyroxine in women with thyroid peroxidase antibodies before conception”. The New England Journal of Medicine 380 (2019): 1316-1325.
  14. Ong SG and Choy CH. “Autoimmune thyroid disease in a cohort of Malaysian SLE patients: frequency ,clinical and immunological associations”. Lupus 25 (2016): 67-74.
  15. Kim NY., et al. “Thyroid autoimmunity and its association with cellular and humoral immunity in women with reproductive failures”. American Journal of Reproductive Immunology 65 (2011): 78-87.
  16. Allesandru D and Garcia-Vellasco JA. “Levothyroxine and thyroid peroxidase antibodies in women with Recurrent pregnancy loss”. Fertility and Sterility 3 (2020): 546-546.
  17. Biddal S., et al. “Thyroid Peroxidase Antibodies and Prospective Live Birth Rate: A Cohort Study of Women With Recurrent Pregnancy Loss”. Thyroid 10 (2019): 1465-1474.
  18. Amrane S and McConnel R. “Endocrine causes of Recurrent pregnancy loss”. Seminars in Perinatology 2 (2019): 80-83.
  19. Kulvinder Kochar Kaur., et al. “An Overview of Therapeutic Management of Recurrent Pregnancy Loss”. Journal of Gynecology 3 (2017): 000144.
Citation: Kulvinder Kochar Kaur., et al. “Significance of Thyroid Peroxidase Antibodies in Cases of Recurrent Pregnancy Loss in Patients who are Euthyroid-A Short Communication”. EC Gynaecology 9.9 (2020): 01-04.

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