Research Article
Volume 9 Issue 8 - 2020
The Efficacy of HE4 and ROMA in Prediction of Ovarian Malignancy in Comparison to CA-125 and RMI
Hend S Saleh*, Hala E Sherif, Ahmed Mahmoud Abdou and Ahmed H Elsayad
Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Egypt
*Corresponding Author: Hend S Saleh, Obstetrics and Gynecology Department, Faculty of Medicine, Zagazig University, Egypt.
Received:May 19, 2020; Published: July 25, 2020


Introduction: Cancer of the Ovary is one of the most communal gynecologic malignancy. It has the highest fatality due to its vague and unspecific clinical presentation.

Aim of the Study: Is the evaluation of CA-125, RMI, HE4, and ROMA as diagnostic concert amongst women with nonfunctional ovarian cysts for cancer recognition

Methods: It is a prospective clinical study in females presented by ovarian cysts ≥ 4 cm who were prepared for surgery at Zagazig University hospital, Egypt between April 2018 and July 2019. Ultrasound findings and blood sample assembly were accomplished pre- operative. All information and pathologic results were achieved and were evaluated statistically under SPSS software version 21.

Results: 140 females with ovarian cysts were assessed. (75.7%) were benign and (24.3%) were malignant. HE4 had the lowest sensitivity( 51.2%) and the highest specificity (96.9%). In comparison to CA125, it had NPV (90.3% vs. 94.1%) and PPV (89.2% vs. 27.9%) in distinguishing between malignant and benign ovarian tumors. ROMA of postmenopausal women had sensitivity (90.1%) which is slightly more than that of CA125 (88.1%) and NPV (91.6%) which is slightly lower than that of CA125 (94.1%). Also, higher specificity (72.1% vs.( 43.7%) {postmenopausal} and (89.2%vs 43.7%) {premenopausal} and PPV (46.9% vs. 27.9%). HE4 at 70 pMol/L, would provide the sensitivity (71.2%) and specificity (84.3%) to distinguish between benign and malignant ovarian tumors which were analogous to diagnostic value of ROMA.

Conclusion: CA-125 and RMI had lesser performance than ROMA and HE4 as they had (higher specificity, PPV) when matched to CA-125 and RMI. Also 70 pMol/L of HE4 could be the firsthand cutoff value for ovarian cysts differentiation

Keywords: Cancer; Ovary; CA125; RAI; ROMA; HE4


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Citation: Hend S Saleh., et al. “The Efficacy of HE4 and ROMA in Prediction of Ovarian Malignancy in Comparison to CA-125 and RMI”. EC Gynaecology 9.8 (2020): 50-54.

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