Research Article
Volume 9 Issue 8 - 2020
The Response of the Local Immune System to the Introduction of Polypropylene Synthetic Implants (Experimental Study)
Palastin PM1*, Bezhenar VF1, Petrov VA2, Azhimova Sholpan2 and Revenko Anastassiya2
1Department of Obstetrics, Gynecology and Neonatology, "The First St. Petersburg State Medical University Named After Academician I. P. Pavlov" of the Ministry of Health of the Russian Federation, Russia
2"State Research Institute of Highly Pure Biopreparations" of Federal Medico-Biological Agency of Russia, Saint - Petersburg, Russia
*Corresponding Author: Palastin PM, Department of Obstetrics, Gynecology and Neonatology, "The First St. Petersburg State Medical University Named After Academician I. P. Pavlov" of the Ministry of Health of the Russian Federation, Russia.
Received:March 5, 2020; Published: July 09, 2020


The number of operations increases together with the number of implant-associated complications despite the good biocompatibility and inertness of modern mesh implants. The pathogenesis of these complications is important to be investigated in the conditions of the experiment. This study aims at investigating the peculiarities of tissue reactions in the experiment with introduction of a suspension from polypropylene mesh implant into the abdomen with minimal surgical trauma. The fragment of the implant frozen in the cryostat was cut with a microtome to particles smaller than 10 μm, then dried, sterilized, resuspended in sterile saline, and injected intraperitoneally to small laboratory mice with a syringe. The parameters of the functional activity of various biologically active substances were further examined to estimate the reactions of the experimental animals to the introduction of a mesh implant. The animals were withdrawn from the experiment after 20, 40, and 60 days. On the 20th day after the suspension introduction, the phagocytic index significantly decreased by 25%. The values of IL-1 and IL-5 in the lavage samples did not exceed the sensitivity of the used method (25 pg/ml). Elevated levels of IL-4, IL-6, IL-22 and interferon-ɣ were found in the lavage of only few animals. Thus, a good biocompatibility and inertness of the synthetic material have been confirmed. A moderate local immunosuppressive effect of the implant suggests that any deviations in the more traumatic surgical manipulations than in the experiment will increase the risk of complications. In addition, the degree of local immunosuppression depends on the tissue condition at the time of surgery. Moreover, the method of the exudate extraction at any stage of the postoperative period can be used for other purposes.

Keywords: Mesh Implants; Tissue Reaction; Biocompatibility; Experimental Animals


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Citation: Palastin PM., et al. “The Response of the Local Immune System to the Introduction of Polypropylene Synthetic Implants (Experimental Study)”. EC Gynaecology 9.8 (2020): 05-09.

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