Research Article
Volume 9 Issue 7 - 2020
Receptor Status of Women with Uterine Fibroids and Adenomyosis
Gutikova LV*, Kukharchyk YV and Pavlovskaya MA
Grodno State Medical University, Grodno, Belarus
*Corresponding Author: Gutikova LV, Grodno State Medical University, Grodno, Belarus.
Received: April 14, 2020; Published: June 02, 2020




Abstract

Based on these studies, it was found that in women with uterine fibroids, combined with adenomyosis, there is a pronounced endometrial dysfunction, manifested by a violation of secretory transformations, an increase in fibroblastic changes in stromal cells and its progressive fibrosis, damage to the surface epithelium of the endometrium, a decrease in the level of expression of progesterone receptors and an increase intensities of expression of estrogen receptors both in the nuclei of superficial epithelial cells and gland glandulocytes and in stromal cells. Due to impaired reproductive health in women with myoma uterus and adenomyosis. When choosing therapeutic measures, it is necessary to evaluate two conditions: the morphotype of the node and the presence of adenomyosis. Drug therapy should include the appointment of progestins or antiestrogen drugs.

Keywords: Uterine Fibroids; Adenomyosis; Estrogen Receptors; Progesterone Receptors

References

  1. Andreeva EN. “Review of a new clinical protocol for the diagnosis and treatment of uterine fibroids: the Ministry of Health strongly recommends”. Status PG Raesens 1 (2016): 41-50.
  2. Baranov VS. “Endometriosis and uterine fibroids from the perspective of systemic genetics”. Journal of Obstetrics and Women's Diseases (2016): 5-7.
  3. Genton YC. “Histopathology aspect of lesions”. Archives of Gynecology and Obstetrics 2 (1994): 76-79.
  4. Kazachkov EL., et al. “Morphological and functional characteristics of the uterine mucosa in women with the syndrome of early pregnancy loss of infectious origin”. The Archives of Pathology 1 (2010): 23-26.
  5. Khorolsky VA. “The rationale for performing myomectomy in women with infertility associated with uterine myoma”. Practical Medicine93 (2016): 91-94.
  6. Kim JJ. “The role of progesterone signaling in the pathogenesis of uterine leiomyoma”. Molecular and Cellular Endocrinology 2 (2012): 223-231.
  7. Kogan EA., “Morphological and immunohistochemical parallels in endometrial hyperplasia”. Medicine 6 (2007): 21-24.
  8. Lenis NE and NA Root. “A differentiated approach to the treatment of uterine fibroids, taking into account the determination of the content of estrogen and progesterone receptors”. Problems of Reproduction 3 (2009): 24-29.
  9. Lieberman JR., et al. “Estrogen and progesterone receptors in uterine artery of rats during and after pregnancy”. European Journal of Obstetrics and Gynecology and Reproductive Biology 51 (1993): 158-166.
  10. Podzolkova NM., et al. “Myoma uterus”. M: GEOTAR-Media (2015).
  11. Richards PA and AJ Tiltman. “Anatomical variation of the estrogen receptor in the non–neoplastic myometrium of fibromyomatous uteri”. Virchows Archiv8 (1996): 265-275.
  12. Sidorova, I.S. “Uterine fibroids (modern problems of etiology, pathogenesis, diagnosis and treatment)”. MIA (2003): 256.
  13. Strizhakov NV., et al. “The role of sex hormones and their receptor apparatus in the selection of treatment methods for patients with endometrial hyperplastic processes in combination with uterine myoma”. Obstetrics and Gynecology 3 (2008): 30-33.
  14. C Nezhat., et al. “Strong Association Between Endometriosis and Symptomatic Leiomyomas”. Journal of the Society of Laparoendoscopic Surgeons 3 (2016): 20-23.
  15. B Carranza-Mamane., et al. “The management of uterine fibroids in women with otherwise unexplained infertility”. Journal of Obstetrics and Gynaecology Canada 3 (2015): 277-285.
  16. LE Corona., et al. “Use of other treatments before hysterectomy for benign conditions in a statewide hospital collaborative”. American Journal of Obstetrics and Gynecology 3 (2015): 304-307.
  17. Wilsin EA., et al. “Estradiol and progesterone binding in uterine leiomyomata and in normal uterine tissues”. Obstetrics and Gynecology 55 (1980): 347-353.
Citation: Gutikova LV., et al. “Receptor Status of Women with Uterine Fibroids and Adenomyosis”. EC Gynaecology 9.7 (2020): 10-16.

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