Case Study
Volume 9 Issue 3 - 2020
New Criteria for the Use of Growth Hormone in the Treatment of Female Infertility: Minireview and a Case Series
Jan Tesarik* and Raquel Mendoza-Tesarik
MARGen Clinic, Granada, Spain
*Corresponding Author: Jan Tesarik, MARGen Clinic, Granada, Spain.
Received: January 26, 2020; Published: February 18, 2020


Most studies published so far suggest that the administration of growth hormone (GH) during ovarian stimulation improves in vitro fertilization (IVF) outcomes, especially in older women, but also in some younger ones who suffered repeated IVF failures during their previous IVF attempts. However, clearly defined criteria with which to distinguish between those women who are likely to benefit from GH treatment and those who are not are still lacking. This minireview resumes the latest advances as to the indication of GH for female infertility treatment. A small case series, showing one way how to address this question, is also included.

Keywords: Growth Hormone Treatment; Insulin-Like Growth Factor-1; Female Infertility; Diagnostic Criteria; Treatment Strategies


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  2. Weall BM., et al. “A direct action for GH in improvement of oocyte quality in poor-responder patients”. Reproduction 149 (2015): 147-154.
  3. Keane KN., et al. “Single-centre retrospective analysis of growth hormone supplementation in IVF patients classified as poor-prognosis”. British Medical Journal 7 (2017): e018107.
  4. Keane KN., et al. “DHEA supplementation confers no additional benefit to that of growth hormone on pregnancy and live birth rates in IVF patients categorized as poor prognosis”. Frontiers in Endocrinology 9 (2018): 14.
  5. Lan KC., et al. “Growth hormone supplementation may improve the pregnancy rate and endometrial receptivity among women aged more than 40 years undergoing in vitro fertilization”. Biomedical Journal 42 (2019): 411-416. 
  6. Blumenfeld Z., et al. “Growth hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles, in clonidine negative but not clonidine positive patients”. Human Reproduction 9 (1994): 209-213.
  7. Hazout A., et al. “Effect of growth hormone on oocyte competence in patients with multiple IVF failures”. Reproductive Biomedicine Online 18 (2009): 664-670. 
  8. de Ziegler D., et al. “The value of growth hormone supplementation in ART for poor ovarian responders”. Fertility and Sterility 96 (2011): 1069-1075.
  9. Altmäe S., et al. “Effect of growth hormone on uterine receptivity in women with repeated implantation failure in an oocyte donation program: a randomized controlled trial”. Journal of the Endocrine Society 2 (2017): 96-105. 
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  11. Bassiouny YA., et al. “Does the addition of growth hormone to the in vitro fertilization/intracytoplasmic sperm injection protocol improve outcomes in poor responders? A randomized, controlled trial”. Fertility and Sterility 105 (2016): 697-702.
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  17. Yovich JL., et al. “The concept of growth hormone deficiency affecting clinical prognosis in IVF”. Frontiers in Endocrinology 10 (2019): 650.
  18. Zhu H., et al. “Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy chinese adults”. PLoS One 12 (2017): e0185561.
  19. Yovich JL., et al. “Growth hormone adjuvant trial for poor responders undergoing IVF”. European Journal of Obstetrics Gynecology and Reproductive Biology 236 (2019): 249.
  20. Xu Y-M., et al. “Application of growth hormone in in vitro fertilization”. Frontiers in Endocrinology 10 (2019): 502.
Citation: Jan Tesarik and Raquel Mendoza-Tesarik. “New Criteria for the Use of Growth Hormone in the Treatment of Female Infertility: Minireview and a Case Series”. EC Gynaecology 9.3 (2020): 01-07.

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