Case Study
Volume 9 Issue 3 - 2020
New Criteria for the Use of Growth Hormone in the Treatment of
Female Infertility: Minireview and a Case Series
MARGen Clinic, Granada, Spain
*Corresponding Author: Jan Tesarik, MARGen Clinic, Granada, Spain.
Received: January 26, 2020; Published: February 18, 2020
Abstract
Most studies published so far suggest that the administration of growth hormone (GH) during ovarian stimulation improves in vitro fertilization (IVF) outcomes, especially in older women, but also in some younger ones who suffered repeated IVF failures during their previous IVF attempts. However, clearly defined criteria with which to distinguish between those women who are likely to benefit from GH treatment and those who are not are still lacking. This minireview resumes the latest advances as to the indication of GH for female infertility treatment. A small case series, showing one way how to address this question, is also included.
Keywords: Growth Hormone Treatment; Insulin-Like Growth Factor-1; Female Infertility; Diagnostic Criteria; Treatment Strategies
References
- Tesarik J., et al. “Improvement of delivery and live birth rates after ICSI in women aged >40 years by ovarian co-stimulation with growth hormone”. Human Reproduction 20 (2005): 2536-2541.
- Weall BM., et al. “A direct action for GH in improvement of oocyte quality in poor-responder patients”. Reproduction 149 (2015): 147-154.
- Keane KN., et al. “Single-centre retrospective analysis of growth hormone supplementation in IVF patients classified as poor-prognosis”. British Medical Journal 7 (2017): e018107.
- Keane KN., et al. “DHEA supplementation confers no additional benefit to that of growth hormone on pregnancy and live birth rates in IVF patients categorized as poor prognosis”. Frontiers in Endocrinology 9 (2018): 14.
- Lan KC., et al. “Growth hormone supplementation may improve the pregnancy rate and endometrial receptivity among women aged more than 40 years undergoing in vitro fertilization”. Biomedical Journal 42 (2019): 411-416.
- Blumenfeld Z., et al. “Growth hormone co-treatment for ovulation induction may enhance conception in the co-treatment and succeeding cycles, in clonidine negative but not clonidine positive patients”. Human Reproduction 9 (1994): 209-213.
- Hazout A., et al. “Effect of growth hormone on oocyte competence in patients with multiple IVF failures”. Reproductive Biomedicine Online 18 (2009): 664-670.
- de Ziegler D., et al. “The value of growth hormone supplementation in ART for poor ovarian responders”. Fertility and Sterility 96 (2011): 1069-1075.
- Altmäe S., et al. “Effect of growth hormone on uterine receptivity in women with repeated implantation failure in an oocyte donation program: a randomized controlled trial”. Journal of the Endocrine Society 2 (2017): 96-105.
- Efekhar M., et al. “Adjuvant growth hormone therapy in antagonist protocol in poor responders undergoing assisted reproductive technology”. Archives of Gynecology and Obstetrics 287 (2013): 1017-1021.
- Bassiouny YA., et al. “Does the addition of growth hormone to the in vitro fertilization/intracytoplasmic sperm injection protocol improve outcomes in poor responders? A randomized, controlled trial”. Fertility and Sterility 105 (2016): 697-702.
- Green H., et al. “A dual effector theory of growth-hormone action”. Differentiation 29 (1985): 195-198.
- Underwood LE., et al. “Paracrine functions of somatomedins”. Clinics in Endocrinology and Metabolism 15 (1986): 59-77.
- Ipsa E., et al. “Growth hormone and insulin-like growth factor action in reproductive tissues”. Frontiers in Endocrinology 10 (2019): 777.
- Mendoza C., et al. “Follicular fluid markers of oocyte developmental potential”. Human Reproduction 17 (2002): 1017-1022.
- Peacey SR Shalet SM. “Insulin-like growth factor 1 measurement in diagnosis and management of acromegaly”. Annals of Clinical Biochemistry 38 (2001): 297-303.
- Yovich JL., et al. “The concept of growth hormone deficiency affecting clinical prognosis in IVF”. Frontiers in Endocrinology 10 (2019): 650.
- Zhu H., et al. “Reference ranges for serum insulin-like growth factor I (IGF-I) in healthy chinese adults”. PLoS One 12 (2017): e0185561.
- Yovich JL., et al. “Growth hormone adjuvant trial for poor responders undergoing IVF”. European Journal of Obstetrics Gynecology and Reproductive Biology 236 (2019): 249.
- Xu Y-M., et al. “Application of growth hormone in in vitro fertilization”. Frontiers in Endocrinology 10 (2019): 502.
Citation: Jan Tesarik and Raquel Mendoza-Tesarik. “New Criteria for the Use of Growth Hormone in the Treatment of Female Infertility: Minireview and a Case Series”. EC Gynaecology 9.3 (2020): 01-07.
Copyright: © 2020 Jan Tesarik and Raquel Mendoza-Tesarik. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Journal Menu
Articles 
Downloads
PubMed Indexed Article
EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.
PMID: 31143884 [PubMed]
PMCID: PMC6536005
EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.
PMID: 31565701 [PubMed]
PMCID: PMC6764777
EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.
PMID: 27747317 [PubMed]
PMCID: PMC5065347
EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?
PMID: 31460519 [PubMed]
PMCID: PMC6711478
EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?
PMID: 30215059 [PubMed]
PMCID: PMC6133253
EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.
PMID: 30417173 [PubMed]
PMCID: PMC6226033
EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.
PMID: 30264037 [PubMed]
PMCID: PMC6155992
EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.
PMID: 30198026 [PubMed]
PMCID: PMC6124505
EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.
PMID: 30294723 [PubMed]
PMCID: PMC6169793
EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs
PMID: 29285526 [PubMed]
PMCID: PMC5743211
EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique
PMID: 29911204 [PubMed]
PMCID: PMC5999047
EC Microbiology
Macrophages and the Viral Dissemination Super Highway
PMID: 26949751 [PubMed]
PMCID: PMC4774560
EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.
PMID: 27390782 [PubMed]
PMCID: PMC4933318
EC Microbiology
Reactive Oxygen Species in HIV Infection
PMID: 28580453 [PubMed]
PMCID: PMC5450819
EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population
PMID: 26280024 [PubMed]
PMCID: PMC4533840
EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis
PMID: 28066845 [PubMed]
PMCID: PMC5214344
EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology
PMID: 28936490 [PubMed]
PMCID: PMC5604476
EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia
PMID: 28713879 [PubMed]
PMCID: PMC5510658
EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature
PMID: 28133641 [PubMed]
PMCID: PMC5267489
EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling
PMID: 29333536 [PubMed]
PMCID: PMC5766278
EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.
PMID: 31032493 [PubMed]
PMCID: PMC6483108
EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.
PMID: 30957099 [PubMed]
PMCID: PMC6448571
EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.
PMID: 30101228 [PubMed]
PMCID: PMC6086333
EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.
PMID: 31080964 [PubMed]
PMCID: PMC6508883
EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.
PMID: 31093608 [PubMed]
PMCID: PMC6513001
EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.
PMID: 31552397 [PubMed]
PMCID: PMC6758937
EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.
PMID: 31681909 [PubMed]
PMCID: PMC6824723
EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.
PMID: 31681910 [PubMed]
PMCID: PMC6824726
EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.
PMID: 31528859 [PubMed]
PMCID: PMC6746603
EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?
PMID: 31276119 [PubMed]
PMCID: PMC6604646
EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.
PMID: 31406965 [PubMed]
PMCID: PMC6690616
EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.
PMID: 31517314 [PubMed]
PMCID: PMC6741290
EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.
PMID: 31633124 [PubMed]
PMCID: PMC6800226
EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.
PMID: 29662969 [PubMed]
PMCID: PMC5898812
EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.
PMID: 30215058 [PubMed]
PMCID: PMC6133268
News and Events
September Issue Release
We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the September issue of respective journals and can be viewed in the current issue pages.
Submission Deadline for October Issue
Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the November issue of respective journals. Submissions are accepted on/before October 07, 2020.
Certificate of Publication
Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.
Best Article of the Issue
Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.
Certifying for Review
Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.
Latest Articles
The latest articles will be updated immediately on the articles in press page of the respective journals.
Immediate Assistance
The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to editor@ecronicon.uk
