Research Article
Volume 9 Issue 3 - 2020
Prevalence and Characterization of High-Risk Human Papillomavirus Genotypes among a Group of Sex Workers in Ouagadougou, Burkina Faso
Régine Ilboudo1,3,4, Esther MA Traoré1,2, Théodora Mahoukèdè Zohoncon1,2,5, Rogomenoma Alice Ouédraogo1,2, Ina Marie Angèle Traore1,2, Prosper Bado1,2,Florencia Wendkuuni Djigma1,2, Dorcas Obiri-Yeboah6, Jean Sakandé4, Jacques Simpore1,2,5 and Charlemagne Ouedraogo1,3,4*
1Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Burkina Faso
2Pietro Annigoni Biomolecular Research Centre (CERBA), Burkina Faso
3Obstetrician-gynecologist, UFR/SDS, University of Ouagadougou, Burkina Faso
4Yalgado Ouedraogo University Hospital (CHU/YO), Burkina Faso
5Faculty of Medicine, University Saint Thomas d’Aquin, Burkina Faso
6Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Ghana
*Corresponding Author: Charlemagne Ouedraogo, Laboratory of Molecular Biology and Genetics (LABIOGENE), University of Ouagadougou, Burkina Faso.
Received: December 05, 2019; Published: February 06, 2020




Abstract

Background: Human papillomavirus (HPV) is the most common cause of cervical cancer worldwide. The aim of this study was to determine the prevalence and to characterize circulating high-risk HPV genotypes among female sex workers in Ouagadougou.

Patients and Methods: A total of 200 sex workers voluntarily agreed to take part in this study and swabs were taken from the endocervical canal for HPV detection. Real-time PCR was used for HPV genotype identification.

Results: Overall HPV carriage infection was 53%. One hundred six (106) sex workers were positive for at least one high-risk HPV genotype. Fourteen genotypes corresponding to 225 infections, were characterized: HPV 68 (14.6%), HPV 31 (12%), HPV 52 (9.3%), HPV 51 (8.9%), HPV 56 (7, 6%), HPV 66 (7.6%), HPV 58 (7.1%), HPV 35 (7.1%), HPV 39 (6.2%), HPV 18 (6.2%), HPV 45 (5.8%), HPV 59 (3.1%), HPV 16 (2.7%), HPV 33 (1.8%). Multiple infection (2 - 9 genotypes) was detected in 53.8% of infected sex workers. The number of sexual partners was statistically associated with carriage of HPV (p ≤ 0.01, OR = 2.000, 95% CI = 0.56 - 7.14), early intercourse was not.

Conclusion: The prevalence of HPV carriage in this study was high and associated with having a high number of multiple infections. Primary preventions such as sex education and vaccine use could significantly decrease the incidence of HPV infections.

Keywords: Sex-Workers; HPV; Genotypes; PCR

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Citation: Charlemagne Ouedraogo., et al. “Prevalence and Characterization of High-Risk Human Papillomavirus Genotypes among a Group of Sex Workers in Ouagadougou, Burkina Faso”. EC Gynaecology 9.3 (2020): 01-09.

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