Mini Review
Volume 7 Issue 2 - 2020
Porto-Splenic Thrombosis-An Intriguing Complication of Tuberculosis
Deepak Jain1*, Shaveta Dahiya2, Pavan Kumar YM3 and Jay Prakash Kumar3
1Associate Professor, Department of Medicine, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
2Assistant Professor, Department of Medicine, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
3Resident, Department of Medicine Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India
*Corresponding Author: Deepak Jain, Associate Professor, Department of Medicine, Pt. B.D. Sharma University of Health Sciences, Rohtak, Haryana, India.
Received: December 18, 2019; Published: January 11, 2020


Tuberculosis is one of the most common infectious diseases in developing countries. Rather than a localized disease it is now considered as a cause of systemic inflammation. Thrombovascular complications secondary to tuberculosis are now increasingly been reported. Porto splenic thrombosis is one such rare category which sometimes presents as an atypical manifestation of tuberculosis. In this article we reviewed various case reports of Porto splenic thrombosis and discuss about the mechanism behind it.

Keywords: Porto Splenic Thrombosis; Tuberculosis (TB)


  1. Sasindran Smitha J and Torrelles JB. “Mycobacterium Tuberculosis Infection and Inflammation: what is Beneficial for the Host and for the Bacterium?”. Frontiers in Microbiology 2.2 (2011): 1-16. 
  2. Alikhan R., et al. “Risk factors for venous thromboembolism in hospitalized patients with acute medical illness: analysis of the MEDENOX Study”. Archives of Internal Medicine 164.9 (2004): 963-968.
  3. Dentan C., et al. “Active tuberculosis and venous thromboembolism: association according to international classification of diseases, ninth revision hospital discharge diagnosis codes”. Clinical Infectious Diseases 58.4 (2014): 495-501. 
  4. Gupta A., et al. “Pulmonary tuberculosis - An erging risk factor for venous thromboembolism: A case series and review of literature”. Lung India 34.1 (2017): 65-69. 
  5. Kakkar N., et al. “Aseptic cerebral venous thrombosis associated with abdominal tuberculosis”. Neurology India 51 (2003): 128-129.
  6. Fullerton DG., et al. “Pulmonary tuberculosis presenting with central retinal vein occlusion”. British Journal of Ophthalmology 91 (2007): 1714-1715.
  7. Sharma A and Sharma V. “Abdominal aortic thrombosis and tuberculosis: an uncommon association”. Gastroenterol Reports 2.4 (2014): 311-312.
  8. Jain D., et al. “Disseminated tuberculosis manifesting as hepatic abscess and IVC thrombus: A rare presentation”. Erciyes Medical Journal 40.2 (2018): 103-106. 
  9. Kourilsky R., et al. “Obstructive jaundice with portal hypertension caused by compression of the hepatic pedicle by tuberculous lymph nodes”. Bulletins et Mémoires de la Société Médicale des Hôpitaux de Paris 20.77 (1961): 25-30.
  10. Tête R., et al. “Segmental portal hypertension due to bacillar adenopathy compressing the splenic vein”. Rev Lyon médical 19.10 (1970): 421-425.
  11. Ruttenberg D., et al. “Abdominal tuberculosis-A cause of portal vein thrombosis and portal hypertension”. Digestive Diseases and Sciences 36.1 (1991): 112-115. 
  12. Caroli-Bosc FX., et al. “Abdominal tuberculosis involving hepatic hilar lymph nodes. A cause of portal vein thrombosis and portal hypertension”. Journal of Clinical Gastroenterology 25.3 (1997): 541-543.
  13. Gogna A., et al. “Isolated Hepatic Inferior Vena Cava Thrombosis in a Case of Tuberculosis”. Journal, Indian Academy of Clinical Medicine 5.3 (2004): 266-268.
  14. Venkatesh SK., et al. “Macronodular hepatic tuberculosis associated with portal vein thrombosis and portal hypertension”. Australasian Radiology 49.4 (2005): 322-324.
  15. Bhalla AS., et al. “Abdominal lymphatic tuberculosis and portal hypertension”. Gastroentérologie Clinique et Biologique 34.12 (2010): 696-701.
  16. Ozşeker B., et al. “Abdominal tuberculosis leading to portal vein thrombosis, mimicking peritoneal carcinomatosis and liver cirrhosis”. Acta Clinica Belgica 67.2 (2012): 137-139.
  17. Dan X., et al. “Abdominal Tuberculosis Leading to Prehepatic Portal Hypertension: A Case Report”. Journal of Cytology and Histology 5.6 (2014): 1000278. 
  18. Jain D., et al. “Disseminated tuberculosis causing isolated splenic vein thrombosis and multiple splenic abscesses”. Oxford Medical Case Reports 6 (2014): 107-109.
  19. Wariyapperuma UM and Jayasundera CIW. “Peritoneal tuberculosis presenting with portal vein thrombosis and transudative Ascites - a diagnostic dilemma: case report”. BMC Infectious Diseases 15 (2015): 394. 
  20. Turken O., et al. “Hemostatic changes in active pulmonary tuberculosis”. International Journal of Tuberculosis and Lung Disease 6.10 (2002): 927-932.
  21. Rajendran P., et al. “The vascular endothelium and human diseases”. International Journal of Biological Sciences 9.10 (2013): 1057-1069.
  22. Hussain R., et al. “Opsonizing antibodies (IgG1) up-regulate monocyte proinflammatory cytokines tumour necrosis factoralpha (TNF-alpha) and IL-6 but not anti-inflammatory cytokine IL-10 in mycobacterial antigen-stimulated monocytes-implications for pathogenesis”. Clinical Experimental Immunology 123 (2001): 210-218.
  23. Kothari H., et al. “Mycobacterium tuberculosis infection and tissue factor expression in macrophages”. PLoS One 7 (2012): e45700.
  24. Hwang SA., et al. “Mycobacterial trehalose 6,6'-dimycolate induced vascular occlusion is accompanied by subendothelial inflammation”. Tuberculosis 116S (2019): S118-S122.
  25. Esmon CT., et al. “Anticoagulation proteins C and S”. Advances in Experimental Medicine and Biology 214 (1987): 47-54.
  26. Foley JH and Conway EM. “Cross Talk Pathways Between Coagulation and Inflammation”. Circulation Research 118 (2016): 1392-1408.
  27. Ünsal E., et al. “Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis”. Postgraduate Medical Journal 81 (2005): 604-607.
  28. Sarode R., et al. “Hyperaggregation of platelets in intestinal tuberculosis: role of platelets in chronic inflammation”. American Journal of Hematology 48.1 (1995): 52-54.
  29. Gowrinath K., et al. “Unusual complication of cervical tuberculous lymphadenopathy”. Indian Journal of Tuberculosis 58.1 (2011): 35-37.
  30. Puri S., et al. “Tuberculous abdominal lymphadenopathy causing reversible renovascular hypertension”. The Journal of the Association of Physicians of India 48.5 (2000): 530-532.
  31. White NW. “Venous thrombosis and rifampicin”. Lancet 2.8660 (1989): 434-435.
  32. Saluja M., et al. “Rifampicin containing ATT regimen as an emerging cause of thromboembolic complications”. Journal of Evidence Based Medicine and Healthcare 5.45 (2018): 3164-3167.
  33. Sadanshiv M., et al. “Rifampicin-induced immune allergic reaction”. Tropical Doctor 48.2 (2018): 156-159.
Citation: Deepak Jain., et al. “Porto-Splenic Thrombosis-An Intriguing Complication of Tuberculosis”. EC Gastroenterology and Digestive System 7.2 (2020): 01-06.

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