Review Article
Volume 7 Issue 2 - 2020
Non Alcoholic Fatty Liver Disease: Participation of Genetic, Metabolic, Biochemical and Immunologic Factors in the Pathogenesis
Tania Beatriz Romero-Adrián*
Graduate Studies in Immunology, Institute of Biological Research, Faculty of Medicine, University of Zulia, Venezuela
*Corresponding Author: Tania Beatriz Romero- Adrián, Graduate Studies in Immunology, Institute of Biological Research, Faculty of Medicine, University of Zulia, Venezuela.
Received: September 20, 2019; Published: January 09, 2020


Non Alcoholic Fatty Liver Disease (NAFLD) occurs as a result of the accumulation of free fatty acids (FFA) y Triglycerides (TG) in the cytoplasm of hepatocytes. There are a correlation between NAFLD and risk factors as obesity, diabetes, dyslipidemia, high blood pressure (HBP), and other conditions related to lifestyle. It is considered a public health problem and studies have demonstrated that a high percentage (90 to 100%) of the obese patients present some degree of NAFLD. It is estimated that by 2030 around 38% of the world population will have overweight and another 20% will be obese. In the pathogenesis of NAFLD participates metabolic, biochemical and immunologic events with continuous stimulation. The establishment, development and progression of NAFLD is due to the accumulation of reactive oxygen species (ROS) as well as inflammation resulting from the up regulated release of pro-inflammatory cytokines from hepatocytes. Investigations appoint that the augment of proinflammatory/profibrotic cytokines and decrease of anti-inflammatory/anti-fibrotic determine an imbalance which leads to the hepatic injury.

In NAFLD the alteration of lipid and carbohydrate metabolism that leads to the accumulation of liver fat is the initial stimulus; the imbalance of cytokines and oxidant/anti-oxidant factors, ROS accumulation and the mobilization of immune cells, oxidative stress, lipotoxicity, apoptosis and fibrosis are processes lead to imminent tissue damage.

Keywords: NAFLD; ROS (Reactive Oxygen Species); Imbalance


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Citation: Tania Beatriz Romero-Adrián. “Non Alcoholic Fatty Liver Disease: Participation of Genetic, Metabolic, Biochemical and Immunologic Factors in the Pathogenesis”. EC Gastroenterology and Digestive System 7.2 (2020): 01-04.

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