Research Article
Volume 7 Issue 2 - 2020
Clinicopathological Features of Enteric Duplication Cysts in Children: A Five Year Study
Meha Mansi1, Arti Khatri2, Nidhi Mahajan2*, CR Gupta3 and Niyaz Ahmed Khan4
1Ex-Senior Resident, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India
2Assistant Professor, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India
3Associate Professor, Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India
4Assistant Professor, Department of Pediatric Surgery, Chacha Nehru Bal Chikitsalaya, Delhi, India
*Corresponding Author: Nidhi Mahajan, Assistant Professor, Department of Pathology, Chacha Nehru Bal Chikitsalaya, Delhi, India.
Received: November 19, 2019; Published: January 09, 2020


Introduction: Enteric duplication cysts (EDC) are rare congenital defects of gastrointestinal tract. They have wide clinical presentation owing to their location and presence of ectopic tissue or lining.

Materials and Methods: Thirty cases of EDC were retrieved from records in past five years and detailed clinicopathological details were studied.

Results: Age ranged from 4 days to 9 years with 60% cases being infants. Most common presenting complaint was abdominal pain. Commonest site was ileum. Unique histopathological features included gastric, respiratory lining epithelium, ectopic pancreatic rests, segmental absence of intestinal muscle, dystrophic calcification, lymphangiectasia and associated ileal and jejunal atresias.

Conclusion: Histopathology is gold standard in establishing diagnosis in EDC. They can be associated with other congenital GI anomalies. Early diagnosis with appropriate intervention may prevent associated untoward events like torsion, perforation, bleeds from ectopic gastric lining and though rare malignant transformation.

Keywords: Duplication; Cysts; GIT; Enteric Cysts; Ectopic Gastric Mucosa; Ectopic Pancreas


  1. Murty TV., et al. “Gastroduodenal duplications”. Journal of Pediatric Surgery 4 (1992): 515-517.
  2. Uzun MA., et al. “A rare case of duodenal duplication treated surgically”. World Journal of Gastroenterology 2 (2009): 882-884.
  3. Stringer MD., et al. “Management of alimentary tract duplication in children”. British Journal of Surgery 82 (1995): 74-78.
  4. Schalamon J., et al. “Experience with gastrointestinal duplications in childhood”. Langenbeck's Archives of Surgery 385.6 (2000): 402-405.
  5. Fitz RH. “Persistent omphalomesentric remains: their importance in the causation of intestinal duplication, cyst formation and obstruction”. The American Journal of the Medical Sciences 88 (1884): 30-57.
  6. Miller RF., et al. “Bronchogenic cysts: anomalies resulting from maldevelopment of the primitive foregut and midgut”. The American Journal of Roentgenology Radium Therapy and Nuclear Medicine 70 (1953): 771-785.
  7. Parker BC., et al. “Gastric duplications in infancy”. The Journal of Pediatrics 7 (1972): 294-298.
  8. Ladd WE and Gross RE. “Surgical treatment of Duplication of the Alimentary Tract: Enterogenous Cysts, Enteric Cysts, or Ileum Duplex”. Surgery, Gynaecology and Obstretrics 70 (1940): 295-307.
  9. Ladd WE. “Abdominal surgery in the infancy and childhood”. Philadelphia: WB Saunders co (1941).
  10. Sharma S., et al. “Foregut cystic developmental malformation: new taxonomy and classification - unifying embryopathological concepts”. Indian Journal of Pathology and Microbiology 52.4 (2009): 461-472.
  11. Sharma S., et al. “Enteric duplication cysts in children: a clinicopathological dilemma”. Journal of Clinical and Diagnostic Research 9 (2015): 8-11.
  12. Macpherson RI. “Gastrointestinal tract duplications: clinical, pathologic, aetiologic, and considerations”. Radiographics 13 (1993): 1063-1080.
  13. Singhal V., et al. “Mediastinal enteric cyst in a neonate”. Journal of Clinical Neonatology 1.3 (2012): 149-151.
  14. Patel P., et al. American Journal of Neuroradiology 32.3 (2011): 40-41.
  15. Lee J., et al. “Cystic lesions of the gastrointestinal tract: multimodality imaging with pathologic correlations”. Korean Journal of Radiology 11.4 (2010): 457-468.
  16. Rai BK., et al. “Duodenal duplication cyst having ectopic gastric and pancreatic tissues”. APSP Journal of Case Reports 3.2 (2012): 15.
  17. Sinha S., et al. “Ileal atresia with intestinal duplication”. Indian Pediatrics 29.12 (1992): 1573-1574.
  18. Xiao-Ming A., et al. “A huge completely isolated duplication cyst complicated by torsion and lined by 3 different mucosal epithelial components in an adult: A case report”. Medicine (Baltimore) 97.44 (2018).
  19. Master VV., et al. “Gastric duplication cyst causing gastric outlet obstruction”. Pediatric Radiology 34 (2004): 574-576.
  20. Zahir I., et al. “Duplication cyst in a newborn”. International Journal of Surgical Pathology 8.2 (2010): 84-86.
Citation: Nidhi Mahajan., et al. “Clinicopathological Features of Enteric Duplication Cysts in Children: A Five Year Study”. EC Gastroenterology and Digestive System 7.2 (2020): 01-07.

PubMed Indexed Article

EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005

EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777

EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347

EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478

EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253

EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033

EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992

EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505

EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793

EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211

EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047

EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560

EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318

EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819

EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840

EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344

EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476

EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658

EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489

EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278

EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108

EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571

EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333

EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883

EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001

EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937

EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723

EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726

EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603

EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646

EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616

EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290

EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226

EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812

EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268

News and Events

June Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the June issue of respective journals and can be viewed in the current issue pages.

Submission Deadline for August Issue

Ecronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the August issue of respective journals. Submissions are accepted on/before July 13, 2020.

Certificate of Publication

Ecronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

Ecronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.

Immediate Assistance

The prime motto of this team is to clarify all the queries without any delay or hesitation to avoid the inconvenience. For immediate assistance on your queries please don't hesitate to drop an email to