Research Article
Volume 7 Issue 2 - 2020
Off Trail Treatment of Hepatitis C with Hemodialysis Patients, Results of an Algerian Cohort
Haouam MA1*, Boumendjel M2 and Hammada T3
1Assistant at the Department of Hepato-gastro-enterology, Tamenrasset Hospital, Algeria
2Assistant at the Department of Hepato-gastro-enterology, CHU Constantine, Algeria
3Professor, Head of the Department of Hepato-gastro-enterology, CHU Constantine, Algeria
*Corresponding Author: Haouam MA, Assistant at the Department of Hepato-gastro-enterology, Tamenrasset Hospital, Algeria.
Received: November 12, 2019; Published: January 09, 2020


Introduction: There is a wild range in the prevalence of HCV infection among hemodialysis patients (HD) patients in different parts of the world, With constant growth in the number of hemodialysis patients associated to a prevalence of 23,8% of infection with hepatitis C 2, Algeria is confronted to a serious public health problem. With constant growth in the number of hemodialysis patients associated to a prevalence of 23,8% of infection with hepatitis C 2, Algeria is confronted to a serious public health problem. 

Methods: We proceeded to a prospective descriptive study including all patients treated for (VHC) on dialysis over a period of one year (January 2017-January 2018) recruited from all hemodialysis centers of the Provence of Constantine. 29 patients were treated, all included in our study, the therapy was based on: Sofosbuvir 400 mg/Ledipasvir 90 mg +/- Ribavirin for 12 or 24 weeks depending on the liver fibrosis status, prescribed after each dialysis, (3 times a week for all our patients). A viral load was requested in pre-therapeutic (as a reference), at the end of treatment and 12 weeks after therefore defining a sustained viral response (SVR). 

Results: A total of 29 patients were treated, all patients were subjected to a viral load in addition to another one performed 12weeks later confirming a 96% success rate (SVR). No patient had to stop the treatment for any side effects. 

Conclusion: The renal clearance of Sofosbuvir makes it difficult to handle in patients with terminal chronic renal insufficiency, however our study shows that with close and strict monitoring we can get a sustained viral response in more than 95% of patients with no significant side effects.

Keywords: Hemodialysis; HCV Infection; Sofosbuvir


  1. “Kidney Disease: improving global outcomes (KDIGO) KDIGO clinical practice guidelines for the prevention, diagnosis evaluation, and treatment of hepatitis C in chronic kidney Disease”. Kidney International Supplements 109 (2008): S1-S99.
  2. National survey of the MSRH-IPA2008 on 7502 samples.
  3. Mbaeyi C and Thompson ND. “Hepatitis C virus screening and management of seroconversions in hemodialysis facilities”. Seminars in Dialysis 26.4 (2013): 439-446.
  4. Shimokura G., et al. “Patient-care practices associated with an increased prevalence of hepatitis C virus infection among chronic hemodialysis patients”. Infection Control and Hospital Epidemiology 32.5 (2011): 415-424.
  5. Jadoul M and Horsmans Y. “Towards eradication of hepatitis C virus from dialysis units”. Lancet 386.10003 (2015): 1514-1515.
  6. Duc B Nguyen., et al. “Transmission of hepatitis C virus in the dialysis setting and strategies for its prevention”. Seminars in Dialysis 32.2 (2019): 127-134.
  7. EASL Recommendations on Treatment of Hepatitis C. “European Association for the Study of the Liver”. Journal of Hepatology (2018).
  8. Lawitz E., et al. “Safety and efficacy of treatment with once-daily ledipasvir/sofosbuvir (90/400 mg) for 12 weeks in genotype 1 HCV-infected patients with severe renal impairment”. Hepatology 66 (2017): 848A.
  9. “Highlights of prescribing information”. 
  10. Zein NN. “Clinical significance of hepatitis C virus genotypes”. Clinical Microbiology Reviews 13.2 (2000): 223-235.
Citation: Haouam MA., et al. “Off Trail Treatment of Hepatitis C with Hemodialysis Patients, Results of an Algerian Cohort”. EC Gastroenterology and Digestive System 7.2 (2020): 01-04.

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