Research Article
Volume 7 Issue 2 - 2020
Off Trail Treatment of Hepatitis C with Hemodialysis Patients, Results of an Algerian Cohort
Haouam MA1*, Boumendjel M2 and Hammada T3
1Assistant at the Department of Hepato-gastro-enterology, Tamenrasset Hospital, Algeria
2Assistant at the Department of Hepato-gastro-enterology, CHU Constantine, Algeria
3Professor, Head of the Department of Hepato-gastro-enterology, CHU Constantine, Algeria
*Corresponding Author: Haouam MA, Assistant at the Department of Hepato-gastro-enterology, Tamenrasset Hospital, Algeria.
Received: November 12, 2019; Published: January 09, 2020




Abstract

Introduction: There is a wild range in the prevalence of HCV infection among hemodialysis patients (HD) patients in different parts of the world, With constant growth in the number of hemodialysis patients associated to a prevalence of 23,8% of infection with hepatitis C 2, Algeria is confronted to a serious public health problem. With constant growth in the number of hemodialysis patients associated to a prevalence of 23,8% of infection with hepatitis C 2, Algeria is confronted to a serious public health problem. 

Methods: We proceeded to a prospective descriptive study including all patients treated for (VHC) on dialysis over a period of one year (January 2017-January 2018) recruited from all hemodialysis centers of the Provence of Constantine. 29 patients were treated, all included in our study, the therapy was based on: Sofosbuvir 400 mg/Ledipasvir 90 mg +/- Ribavirin for 12 or 24 weeks depending on the liver fibrosis status, prescribed after each dialysis, (3 times a week for all our patients). A viral load was requested in pre-therapeutic (as a reference), at the end of treatment and 12 weeks after therefore defining a sustained viral response (SVR). 

Results: A total of 29 patients were treated, all patients were subjected to a viral load in addition to another one performed 12weeks later confirming a 96% success rate (SVR). No patient had to stop the treatment for any side effects. 

Conclusion: The renal clearance of Sofosbuvir makes it difficult to handle in patients with terminal chronic renal insufficiency, however our study shows that with close and strict monitoring we can get a sustained viral response in more than 95% of patients with no significant side effects.

Keywords: Hemodialysis; HCV Infection; Sofosbuvir

References

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Citation: Haouam MA., et al. “Off Trail Treatment of Hepatitis C with Hemodialysis Patients, Results of an Algerian Cohort”. EC Gastroenterology and Digestive System 7.2 (2020): 01-04.

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