Research Article
Volume 9 Issue 3 - 2022
Correlation between Fecal Calprotectin (CP) and Magnetic Resonance Enterography (MRE) in Crohn’s Disease Activity; at Al-Najah National University Hospital: A Retrospective Study
Fadwa Sharabati*, Sara Almansour, Mohammad Ghannam, Saif Atyani, Abdulsalam khayyat, Souad Belkbir and Intisar Alalami
Submitted in Partial Fulfillment of the Requirement for the Degree for Medicine, Faculty of Medicine and Health Science, at An-Najah National University, Nablus, and Palestine
*Corresponding Author: Fadwa Sharabati, Submitted in Partial Fulfillment of the Requirement for the Degree for Medicine, Faculty of Medicine and Health Science, at An-Najah National University, Nablus, and Palestine.
Received: December 16, 2021; Published: February 10, 2022




Abstract

Background: Thanks to technical advances, imaging modalities are playing an increasingly important role both in the diagnosis and in the clinical management of chronic inflammatory bowel disease (IBD), especially with Crohn's disease. The diagnosis of inflammatory bowel disease (IBD) is based on laboratory tests and histological evidence. However, imaging methods have also become an important part of diagnosing and monitoring the progress. Fecal calprotectin (CP) is an established biomarker for evaluating inflammatory processes in the colon. It is used to detect neutrophils in inflammatory tissue and allows a differentiation between inflammatory and non-inflammatory diseases of the lower intestinal tract. Due to the high sensitivity, the analysis of the fecal CP provides reliable information about the intensity of the inflammatory lesion and adequately reflects the disease activity that can be detected endoscopically. This study aims to find the relationship between fecal CP and Magnetic Resonance Enterography (MRE), in the diagnosis and prognosis of Crohn's Disease.

Methods: In order to conduct the correlation between Fecal CP and MRE, a retrospective study was performed on 500 Crohn's-diagnosed patients from Gastroenterology and Radiology department at Al-Najah University hospital; from January 2017 to January 2020 who underwent MRE and Fecal CP (within a period of 30 days).

Results: The mean age of the study participants was 33.5 years, and 64.6% of them were males. The MRE score mean was 1.21, and the mean of Fecal CP levels was 324.44 mcg/g. Moreover, it was noticed that the mean of Fecal CP levels in the score "2" MRE group was 614.9 mcg/g, 103.68 mcg/g in the score "1" group, and 32.4 mcg/g in the score "0" group. The results of the regression model demonstrated that there was a statistically significant relationship between Fecal CP levels and MRE results (r2=0.363, P=0.000).

Conclusion: Fecal calprotectin correlates well with MRE activity, thus Fecal CP could be used as a predictor marker to select for MRE assessment.

Keywords: Fecal Calprotectin; MRE; Chron's Disease; IBD; Magnetic Resonance Imaging

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Citation: Fadwa Sharabati., et al. “Correlation between Fecal Calprotectin (CP) and Magnetic Resonance Enterography (MRE) in Crohn’s Disease Activity; at Al-Najah National University Hospital: A Retrospective Study”. EC Gastroenterology and Digestive System 9.3 (2022): 01-09.

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