Case Report
Volume 8 Issue 6 - 2021
Diffuse Variant Hepatocarcinoma. Case Report
Cynthia Belén Changoluisa B2, Edgar Steven Changoluisa B2, Dayanna Alejandra Tupiza C2, Darío Javier Nuñez C2, Andrea Verónica Castillo R3, Juan Gonzalo Salinas V3, Jessica Johana Álvarez T3, Mónica Paulina Silva T4, Edison Tarsicio Frías R4 and Edgar Ramiro Changoluisa Paredes1*
1Gastroenterologist Doctor, Hospital Instituto Ecuatoriano de Seguridad Social IESS, Ambato, Ecuador
2General Doctor, Hospital Instituto Ecuatoriano de Seguridad Social IESS, Ambato, Ecuador
3Residentes, Hospital Instituto Ecuatoriano de Seguridad Social IESS, Ambato, Ecuador
4Teaching Doctor, Universidad Técnica de Ambato, Ecuador
*Corresponding Author: Edgar Ramiro Changoluisa Paredes, Hospital Instituto Ecuatoriano de Seguridad Social IESS, Ambato, Ecuador.
Received: April 23, 2021; Published: May 28, 2021




Abstract

Hepatocarcinoma is the most common primary liver neoplasm, it is mostly related to liver cirrhosis, and its presentation without concomitant chronic liver disease is rare; however, there is a percentage of non-cirrhotic patients who develop the disease. We present the clinical case of a 24-year-old female patient, with no medical history, who consulted for long-term recurrent mild abdominal pain. After complementary studies, a liver tumor was detected, with alpha-fetoprotein of 974 ng/dl. The definitive pathology report reports a diffuse variant hepatocarcinoma. Given the rarity of presentation, it is decided to present the case.

Keywords: Hepatocarcinoma; Hepatocelular Carcinoma; Ecuador

References

  1. Arevalo J., et al. “Diagnóstico, Tratamiento Médico”. MARBAN (2011): 1983-1987.
  2. Benson A and D Abbott. Hepatobiliary cancers (2020).
  3. Bialecki E. “Diagnosis of hepatocellular carcinoma”. HPB (Oxford) 1 (2005): 26-34.
  4. Blanco M., et al. “Hepatocarcinoma Avanzado” (2017).
  5. Cabbibo G., et al. “A meta-analysis of survival rates of untreated patients in randomized clinical trials of hepatocellular carcinoma”. Hepatology4 (2010): 1274-1283.
  6. “Hepatocellular carcinoma” (2019).
  7. Erazo A., et al. “Recomendaciones interinstitucionales sobre el diagnóstico y tratamiento del hepatocarcinoma Avanzado”. Revista de Especialidades 23 (2018).
  8. Fassio E and G Mazzolini. “Consenso y guías argentinas para la vigilancia, diagnóstico y tratamiento del hepatocarcinoma” (2017).
  9. Flores S., et al. “Revisión del carcinoma fibrolamelar”. Revista Federación Ecuatoriana de Radiología e Imagen2 (2018): 55-58.
  10. Forner A., et al. “Hepatocellular carcinoma”. Lancet10127 (2018): 1301-1314.
  11. Forner A., et al. “Diagnóstico de hepatocarcinoma. Actualización del documento de consenso de la AEEH, SEOM, SERAM, SERVEI, SETH”. Medicina Clinica (2016).
  12. “Cancer today” (2020).
  13. Gonzalez C and S Mancilla. “Avances en imagenología hepatica”. Acta Médica Grupo Ángeles1 (2016).
  14. Greten T., et al. “Targeted and Immune-based Therapies for Hepatocellular Carcinoma”. Gastroenterology 2 (2019): 510-524.
  15. Hepatology Journal of. “EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma” (2018).
  16. Jabbour T., et al. “Update on hepatocellular carcinoma: Pathologists’ review”. World Journal of Gastroenterology 14 (2019): 1653-1665.
  17. Jhonson P., et al. “The detection of hepatocellular carcinoma using a prospectively developed and validated model based on serological biomarkers”. Cancer Epidemiology, Biomarkers and Prevention 1 (2014): 144-153.
  18. Kulik L and B Hashem. “Epidemiology and Management of Hepatocellular Carcinoma”. Gastroenterology2 (2019): 477-491.e1.
  19. Llovet J., et al. “Trial Design and Endpoints in Hepatocellular Carcinoma: AASLD Consensus Conference”. Hepatology 73.1 (2021): 158-191.
  20. Lopez R. “Neoplasias hepáticas malignas: 1.a parte.Hepatocarcinoma: papel de la biopsia hepática, estudios de inmunohistoquímica y otros aspectos importantes”. Revista Colombiana de Gastroenterologia 2 (2016): 232.
  21. Marrero J., et al. “Diagnosis, Staging, and Management of Hepatocellular Carcinoma”. Hepatology2 (2018): 723-750.
  22. Molina K., et al. “Revisión de carcinoma hepatocelular sarcomatoide y presentación de un caso”. Cirujano General4 (2019): 276-283.
  23. Naugler W., et al. “Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production”. Science 317.5834 (2007): 121-124.
  24. Ogunwobi O., et al. “Mechanisms of hepatocellular carcinoma progression”. World Journal of Gastroenterology19 (2019): 2279-2293.
  25. Villanueva A. “Carcinoma Hepatocellular”. New England Journal of Medicine 380.15 (2019): 1450-1462.
  26. Vogel A., et al. “Hepatocellular carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up”. Annals of Oncology 4 (2018): iv238-iv255.
  27. Yang J., et al. “A global view of hepatocellular carcinoma: trends, risk, prevention and management”. Nature Reviews Gastroenterology and Hepatology 10 (2019): 589-604.
Citation: Edgar Ramiro Changoluisa Paredes., et al. “Diffuse Variant Hepatocarcinoma. Case Report”. EC Gastroenterology and Digestive System 8.6 (2021): 63-69.

PubMed Indexed Article


EC Pharmacology and Toxicology
LC-UV-MS and MS/MS Characterize Glutathione Reactivity with Different Isomers (2,2' and 2,4' vs. 4,4') of Methylene Diphenyl-Diisocyanate.

PMID: 31143884 [PubMed]

PMCID: PMC6536005


EC Pharmacology and Toxicology
Alzheimer's Pathogenesis, Metal-Mediated Redox Stress, and Potential Nanotheranostics.

PMID: 31565701 [PubMed]

PMCID: PMC6764777


EC Neurology
Differences in Rate of Cognitive Decline and Caregiver Burden between Alzheimer's Disease and Vascular Dementia: a Retrospective Study.

PMID: 27747317 [PubMed]

PMCID: PMC5065347


EC Pharmacology and Toxicology
Will Blockchain Technology Transform Healthcare and Biomedical Sciences?

PMID: 31460519 [PubMed]

PMCID: PMC6711478


EC Pharmacology and Toxicology
Is it a Prime Time for AI-powered Virtual Drug Screening?

PMID: 30215059 [PubMed]

PMCID: PMC6133253


EC Psychology and Psychiatry
Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse.

PMID: 30417173 [PubMed]

PMCID: PMC6226033


EC Anaesthesia
Arrest Under Anesthesia - What was the Culprit? A Case Report.

PMID: 30264037 [PubMed]

PMCID: PMC6155992


EC Orthopaedics
Distraction Implantation. A New Technique in Total Joint Arthroplasty and Direct Skeletal Attachment.

PMID: 30198026 [PubMed]

PMCID: PMC6124505


EC Pulmonology and Respiratory Medicine
Prevalence and factors associated with self-reported chronic obstructive pulmonary disease among adults aged 40-79: the National Health and Nutrition Examination Survey (NHANES) 2007-2012.

PMID: 30294723 [PubMed]

PMCID: PMC6169793


EC Dental Science
Important Dental Fiber-Reinforced Composite Molding Compound Breakthroughs

PMID: 29285526 [PubMed]

PMCID: PMC5743211


EC Microbiology
Prevalence of Intestinal Parasites Among HIV Infected and HIV Uninfected Patients Treated at the 1o De Maio Health Centre in Maputo, Mozambique

PMID: 29911204 [PubMed]

PMCID: PMC5999047


EC Microbiology
Macrophages and the Viral Dissemination Super Highway

PMID: 26949751 [PubMed]

PMCID: PMC4774560


EC Microbiology
The Microbiome, Antibiotics, and Health of the Pediatric Population.

PMID: 27390782 [PubMed]

PMCID: PMC4933318


EC Microbiology
Reactive Oxygen Species in HIV Infection

PMID: 28580453 [PubMed]

PMCID: PMC5450819


EC Microbiology
A Review of the CD4 T Cell Contribution to Lung Infection, Inflammation and Repair with a Focus on Wheeze and Asthma in the Pediatric Population

PMID: 26280024 [PubMed]

PMCID: PMC4533840


EC Neurology
Identifying Key Symptoms Differentiating Myalgic Encephalomyelitis and Chronic Fatigue Syndrome from Multiple Sclerosis

PMID: 28066845 [PubMed]

PMCID: PMC5214344


EC Pharmacology and Toxicology
Paradigm Shift is the Normal State of Pharmacology

PMID: 28936490 [PubMed]

PMCID: PMC5604476


EC Neurology
Examining those Meeting IOM Criteria Versus IOM Plus Fibromyalgia

PMID: 28713879 [PubMed]

PMCID: PMC5510658


EC Neurology
Unilateral Frontosphenoid Craniosynostosis: Case Report and a Review of the Literature

PMID: 28133641 [PubMed]

PMCID: PMC5267489


EC Ophthalmology
OCT-Angiography for Non-Invasive Monitoring of Neuronal and Vascular Structure in Mouse Retina: Implication for Characterization of Retinal Neurovascular Coupling

PMID: 29333536 [PubMed]

PMCID: PMC5766278


EC Neurology
Longer Duration of Downslope Treadmill Walking Induces Depression of H-Reflexes Measured during Standing and Walking.

PMID: 31032493 [PubMed]

PMCID: PMC6483108


EC Microbiology
Onchocerciasis in Mozambique: An Unknown Condition for Health Professionals.

PMID: 30957099 [PubMed]

PMCID: PMC6448571


EC Nutrition
Food Insecurity among Households with and without Podoconiosis in East and West Gojjam, Ethiopia.

PMID: 30101228 [PubMed]

PMCID: PMC6086333


EC Ophthalmology
REVIEW. +2 to +3 D. Reading Glasses to Prevent Myopia.

PMID: 31080964 [PubMed]

PMCID: PMC6508883


EC Gynaecology
Biomechanical Mapping of the Female Pelvic Floor: Uterine Prolapse Versus Normal Conditions.

PMID: 31093608 [PubMed]

PMCID: PMC6513001


EC Dental Science
Fiber-Reinforced Composites: A Breakthrough in Practical Clinical Applications with Advanced Wear Resistance for Dental Materials.

PMID: 31552397 [PubMed]

PMCID: PMC6758937


EC Microbiology
Neurocysticercosis in Child Bearing Women: An Overlooked Condition in Mozambique and a Potentially Missed Diagnosis in Women Presenting with Eclampsia.

PMID: 31681909 [PubMed]

PMCID: PMC6824723


EC Microbiology
Molecular Detection of Leptospira spp. in Rodents Trapped in the Mozambique Island City, Nampula Province, Mozambique.

PMID: 31681910 [PubMed]

PMCID: PMC6824726


EC Neurology
Endoplasmic Reticulum-Mitochondrial Cross-Talk in Neurodegenerative and Eye Diseases.

PMID: 31528859 [PubMed]

PMCID: PMC6746603


EC Psychology and Psychiatry
Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

PMID: 31276119 [PubMed]

PMCID: PMC6604646


EC Anaesthesia
Real Time Locating Systems and sustainability of Perioperative Efficiency of Anesthesiologists.

PMID: 31406965 [PubMed]

PMCID: PMC6690616


EC Pharmacology and Toxicology
A Pilot STEM Curriculum Designed to Teach High School Students Concepts in Biochemical Engineering and Pharmacology.

PMID: 31517314 [PubMed]

PMCID: PMC6741290


EC Pharmacology and Toxicology
Toxic Mechanisms Underlying Motor Activity Changes Induced by a Mixture of Lead, Arsenic and Manganese.

PMID: 31633124 [PubMed]

PMCID: PMC6800226


EC Neurology
Research Volunteers' Attitudes Toward Chronic Fatigue Syndrome and Myalgic Encephalomyelitis.

PMID: 29662969 [PubMed]

PMCID: PMC5898812


EC Pharmacology and Toxicology
Hyperbaric Oxygen Therapy for Alzheimer's Disease.

PMID: 30215058 [PubMed]

PMCID: PMC6133268


News and Events


January Issue Release

We always feel pleasure to share our updates with you all. Here, notifying you that we have successfully released the November issue of respective journals and the latest articles can be viewed on the current issue pages.

Submission Deadline for Upcoming Issue

ECronicon delightfully welcomes all the authors around the globe for effective collaboration with an article submission for the upcoming issue of respective journals. Submissions are accepted on/before February 14, 2023.

Certificate of Publication

ECronicon honors with a "Publication Certificate" to the corresponding author by including the names of co-authors as a token of appreciation for publishing the work with our respective journals.

Best Article of the Issue

Editors of respective journals will always be very much interested in electing one Best Article after each issue release. The authors of the selected article will be honored with a "Best Article of the Issue" certificate.

Certifying for Review

ECronicon certifies the Editors for their first review done towards the assigned article of the respective journals.

Latest Articles

The latest articles will be updated immediately on the articles in press page of the respective journals.