Systematic Review
Volume 8 Issue 4 - 2021
Does Antibiotics have a Role in the Treatment of Acute Uncomplicated Diverticulitis? A Systematic Review and Meta-Analysis
Ahmad Arsalan Tahir1*, Kiren Ali2, Aswad U Khan3, Sahifa Kamal4, Anwar Hussain5 and Arif U Khan5
1General Surgery, University Hospital of North Midlands, Stoke on Trent, UK
2General Surgery, Wishaw General Hospital, Wishaw, UK
3General Surgery, Medical University of Pleven, Pleven, Bulgaria
4General Surgery, Pak International Medical College, Peshawar, Pakistan
5General Surgery, Mid Cheshire NHS Foundation Trust, Crewe, UK
*Corresponding Author: Ahmad Arsalan Tahir, General Surgery, University Hospital of North Midlands, Stoke on Trent, UK.
Received: February 22, 2021; Published: March 15, 2021


Introduction: Diverticular disease is a common health problem and is associated with high morbidity and economic costs. The clinical spectrum can range from asymptomatic diverticulosis to varying severity of sepsis. About 75% of the patients would have uncomplicated diverticulitis and the condition is treated with antibiotics, analgesia and dietary advice. Recent evidence has shown that the treatment of uncomplicated diverticulitis is controversial and questioning the use of antibiotics. This study aims to assess the role of antibiotics in the treatment of acute uncomplicated diverticulitis.

Methods: This is a systematic review and Meta-analysis. A literature review of the available studies was conducted using online search engines like Pubmed, Medline, Embase, Google Scholar and Cochrane databases. Statistical analysis was conducted using RevMan 5.4.

Results: 1754 records identified. 1324 were duplicates, remaining 430 studies were screened for inclusion. 395 studies were further excluded. 35 full text articles were assessed for eligibility and in the final review 10 studies were included. PRISMA guidelines were used for this study. Pooled OR for recurrence = 0.92 (95% CI = 0.74 to 1.13). Pooled OR for Hospital stay = -0.66 (95% CI = -1.12 to -0.21). Pooled OR for complications = 1.06 (95% CI = 0.69 to 1.64). Pooled OR for treatment failure = 1.24 (95% CI = 0.90 - 1.69).

Conclusion: We conclude that from the available evidence antibiotics have no role in reducing recurrence, complications, treatment failure and duration of hospital stay in acute uncomplicated diverticulitis. However, risk stratification is required for the selected cases that might benefit from antibiotic use.


Keywords: Diverticulosis; Antibiotics; Acute Uncomplicated Diverticulitis; Colonic Diverticulosis


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Citation: Ahmad Arsalan Tahir., et al. “Does Antibiotics have a Role in the Treatment of Acute Uncomplicated Diverticulitis? A Systematic Review and Meta-Analysis”. EC Gastroenterology and Digestive System 8.4 (2021): 49-58.

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