Research Article
Volume 8 Issue 3 - 2021
Interleukin 28B Polymorphism Predicted Treatment Response in Egyptian Children with Chronic Hepatitis C Virus Infection
Yasser K Rashed1*, Mohamed A El Guindi1, Hala H El said2 and Ola Fouad1
1Department of Pediatric Hepatology, Egypt
2Department of Clinical Biochemsitry, National Liver Institute, Menoufiya University, Egypt
*Corresponding Author: Yasser K Rashed1, Department of Pediatric Hepatology, Egypt.
Received: February 01, 2021; Published: February 26, 2021




Abstract

Background: Host genetic factors is the most important factor responsible for spontaneous and treatment-induced clearance of HCV infection from infected patients. Sustained virological response was associated with single nucleotide polymorphisms (SNPs) near the interleukin 28B (IL28B) Purpose: The aim of this study to evaluate the role of a single nucleotide polymorphism rs12979860 near the Interleukin 28B gene in predicting the response to Pegylated interferon-α and ribavirin treatment in chronic hepatitis C virus infected children. Methods: Sixty nine patients were included in this study with chronic HCV infection, from Pediatric Hepatology Department, National Liver Institute, Menoufia University. They were 40 males and 29 females. The mean age of our patients was 11.1± 3.6 years, Detection of the IL28B rs12979860 C/T polymorphism done in 67 patients. Results: The CC genotype of rs12979860 had a higher SVR (78.9%) as compared to the non-CC genotypes (25.0%) with statistically significant difference (P < 0.0001).

Conclusion: IL28B rs12979860 genotyping could be a useful tool for predicting treatment outcome in children with chronic HCV.

Keywords: HCV; ILB28; Polymorphis; Interferon; Genotype

References

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Citation: Yasser K Rashed.,et al. “Interleukin 28B Polymorphism Predicted Treatment Response in Egyptian Children with Chronic Hepatitis C Virus Infection”. EC Gastroenterology and Digestive System 8.3 (2021): 139-146.

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