Research Article
Volume 8 Issue 2 - 2021
Combination of Intragastric Balloon and Liraglutide: Short-Term Results
Anna Carolina Hoff*, Barrichello SA, Galvão Neto M, Grecco E, Bezerra L and Nunes GC
Diagnostic and Therapeutic Digestive Endoscopy/Bariatric and Respiratory Endoscopy, Technical Director Angioskope SP/Vale, Brazil
*Corresponding Author: Anna Carolina Hoff, Diagnostic and Therapeutic Digestive Endoscopy/Bariatric and Respiratory Endoscopy, Technical Director Angioskope SP/Vale, Brazil.
Received: February 13, 2021; Published: February 26, 2021


Introduction: As isolated therapies, intragastric balloon and liraglutide are used throughout the world to treat excess weight and obesity.

Objective: Compare the effectiveness of intragastric balloon therapy alone and combined with liraglutide.

Methods: Ninety patients (64 women) were randomly divided into two groups of 45 people with the same composition (32 women and 13 men). Group 1 underwent isolated therapy with an intragastric balloon (IGB) for a period of six months. Group 2 also received an IGB implant, along with a daily dose of liraglutide (maximum: 3.0 mg).

Results: Mean age was 34.4 years. Mean initial BMI was 33.93 kg/m2 in Group 1 and 33.95 kg/m2 in Group 2. Forty-two patients in Group 1 and 31 in Group 2 completed treatment. The mean reduction in BMI was significantly greater in Group 2 (7.23 ± 1.07) compared to Group 1 (6.21 ± 0.88) (p < 0.001). The same was found regarding percentage of total body weight loss (22.21 ± 2.94 in Group 2 vs. 18.29 ± 2.16 in Group 1), percentage of excess weight loss (86.53 ± 17.06 in Group 2 vs. 71.81 ± 14.50 in Group 1) and absolute weight loss in kg (21.71 ± 3.72 in Group 2 vs. 17.90 ± 2.87 in Group 1) (p < 0.001 for all comparisons).

Conclusion: Both treatments are effective at promoting weight loss. However, the combination of IGB and liraglutide seems to promote greater weight loss without increasing the occurrence of complications. Therefore, liraglutide proved to be a good adjuvant drug for IGB therapy.


Keywords: Bariatric Endoscopy; Intragastric Balloon; Obesity; Bariatric Surgery


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Citation: Anna Carolina Hoff., et al. “Combination of Intragastric Balloon and Liraglutide: Short-Term Results”. EC Gastroenterology and Digestive System 8.2 (2021): 124-131.

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