Mini Review
Volume 8 Issue 3 - 2021
Review: Epidemiology and Pathophysiology of Osteoporosis in Inflammatory Bowel Disease
Kakkar Apeksha*
M.B.B.S, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India
*Corresponding Author: Kakkar Apeksha, M.B.B.S, Grant Government Medical College and Sir J.J. Group of Hospitals, Mumbai, India.
Received: January 28, 2021; Published: February 12, 2021




Abstract

Osteoporosis is a common clinical pathology encountered in everyday medicine and while the foremost population that comes to mind is elderly postmenopausal women, it may affect varied age-groups and indeed, has several causative factors. One such interesting association is between gastrointestinal illnesses like IBD and osteoporosis. Osteoporosis is important to diagnose because it increases the likelihood of fractures and in IBD patients, this should be especially noted because they are often on glucocorticoid therapy, which on its own is responsible for an increase in fragility fractures. With age and decrease in estrogen, the loss of bone mineral density increases. As a result, patients are at an increased risk of developing osteoporosis and subsequent fractures. In IBD subjects, paramount aspect is the early onset of osteopenia and osteoporosis. Hence, guiding us towards the understanding that in addition to age, genetics, and lifestyle, there are a number of factors operating at a molecular and nutritional status level that lead to osteoporosis. This review article discusses the epidemiology and pathophysiology of osteoporosis in IBD patients to help garner an in-depth view of the imbalance in the several factors that play a role in the pathogenesis and provide a composite view of this common association.

Keywords: Inflammatory Bowel Disease (IBD); Crohn’s Disease (CD); Ulcerative Colitis (UC); Osteoporosis

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Citation: Kakkar Apeksha. “Review: Epidemiology and Pathophysiology of Osteoporosis in Inflammatory Bowel Disease”. EC Gastroenterology and Digestive System 8.3 (2021): 110-115.

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