Research Article
Volume 8 Issue 2 - 2021
Prevalence and Predictors of Acute on Chronic Liver Failure in Cirrhotic Patients Hospitalized for Acute Decompensation
Trad Nouha*, Ghanem Mohamed, Ben Slimen Baha, Boughoula Khouloud, Bizid Sondes, Ben Abdallah Hatem, Bouali Riadh and Abdelli Mohamed Nabil
Department of Gastroenterology, Military Hospital of Tunis, Faculty of Medicine of Tunis, Tunis, Tunisia
*Corresponding Author: Trad Nouha, Department of Gastroenterology, Military Hospital of Tunis, Faculty of Medicine of Tunis, Tunis, Tunisia.
Received: November 26, 2020; Published: January 20, 2021


Background: Acute on chronic liver failure (ACLF) is associated with organ failures and high short-term mortality. Our objective was to determine the prevalence and the predictors of ACLF in cirrhotic patients hospitalized for acute decompensation.

Methods: Consecutive cirrhotic patients hospitalized for acute decompensation were recruited from January 2012 to December 2019. Logistic regression analyses were performed to identify clinical and epidemiological predictors of ACLF.

Results: In total, 195 patients were included. The mean age was 65.4 ± 13.1 years and the sex-ratio was 1.7. During follow-up, these patients were admitted to our department 460 times. ACLF occurred in 28.6% of admissions. Grade 1 was the most common (55.3%) followed by Grade 2 (22.7%) and Grade 3 (21.9%). The predictors of ACLF occurrence in our series were: bacterial infection (p < 0.001), CHILD-pugh score (p = 0.001), high MELD score on admission (p = 0,001), advanced age > 50 years (p = 0,02) and history of high blood pressure (p = 0,04). In multivariate analysis, only bacterial infection (p < 0.001, OR = 23.6), CHILD-pugh score (p = 0.02, OR = 20.3) MELD-Na and MELD score (p = 0.003, OR = 10.2) were independent predictors of ACLF.

Conclusion: In our study, the prevalence of ACLF was 28.6% of admissions. As a major precipitating factor, Bacterial infections would require rapid and effective management as well as close monitoring.

Keywords: Liver Cirrhosis; ACLF; Bacterial Infection; Prevalence; Predictors


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Citation: Trad Nouha., et al. “Prevalence and Predictors of Acute on Chronic Liver Failure in Cirrhotic Patients Hospitalized for Acute Decompensation”. EC Gastroenterology and Digestive System 8.2 (2021): 36-43.

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