Research Article
Volume 7 Issue 9 - 2020
Screening of the Patients with Autoimmune Thyroid Disease (AITD) and Type 1 Diabetes Mellitus (DM1) for Atrophic Gastritis (AG) by Serological Biomarker Testing (GastroPanel®)
Olli-Pekka Koivurova1, Olavi Ukkola2, Minna Koivikko2, Tapani Ebeling2, Iina Yliaska2, Ritva Koskela2, Timo Blomster2, Antti Ala-Rämi2, Olli Kettunen2, Tuomo J Karttunen3, Markus Mäkinen3,4, Jukka Ronkainen5,6 and Kari Syrjänen7,8*
1Departmernt of Endoscopy, Terveystalo Medical Center, Oulu, Finland
2Research Unit of Internal Medicine, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Finland
3Cancer and Translational Medicine Research Unit, University of Oulu, Finland
4Department of Pathology, Oulu University Hospital, Finland
5Center for Life Course Health Research, University of Oulu, Finland
6Primary Health Care Center, Tornio, Finland
7Molecular Oncology Research Center, Barretos Cancer Hospital, Barretos, Brazil
8SMW Consultants Ltd., Kaarina, Finland
*Corresponding Author: Kari Syrjänen, Professor, SMW Consultants Ltd., Kaarina, Finland.
Received: July 09, 2020; Published: August 29, 2020




Abstract

Background: The high prevalence (10 - 30%) of autoimmune atrophic gastritis (AAG/AG) in patients with autoimmune thyroid disease (AITD) or type 1 diabetes mellitus (DM1) advocates a screening of these patients by gastroscopy. An alternative to invasive gastroscopy is offered by a non-invasive serological biomarker test; GastroPanel® (Biohit Oyj, Helsinki, Finland).

Objective: To establish the prevalence of AAG/AG in AITD- and DM1 patients by the new-generation GastroPanel® test in a clinical validation study.

Material and Methods: A cohort of 244 patients (207 with AITD and 37 with DM1) was enrolled at the Outpatient Department of Internal Medicine, Oulu University Hospital (OUH, Oulu, Finland). A written consent was obtained from all patients, and the study was approved by the joint Ethical Committee of OUH/Oulu University (Dno 28/2017). All patients underwent GastroPanel® examination and those with AG/AAG biomarker profile were referred for gastroscopy and biopsy confirmation (reference test).

Results: Of the 244 patients, biopsy-confirmed AG was found in 12.0% (25/207) of the AITD- and in 10.8% (4/37) of the DM1 patients. The adjusted overall agreement between GastroPanel® and the USS classification was 73.3% (95%CI 60.4 - 86.2%), and the adjusted weighted kappa: kw = 0.881 (95%CI 0.783 - 0.935). In ROC analysis for AGC2+ (moderate/severe AGC) endpoint, the ROC curves have AUC = 0.939 (95%CI 0.870 - 1.000) and AUC = 0.945 (95%CI 0.879 - 1.000) for PGI and PGI/PGII, respectively.

Conclusion: AG/AAG is far more prevalent among the AITD- and DM1 patients as compared with general population. The new generation GastroPanel® is an ideal test for non-invasive screening of these patients for early diagnosis of AG/AAG.

Keywords: Autoimmune Thyroid Disease (AITD); Type I Diabetes Mellitus (DM1); Autoimmune Atrophic Gastritis (AAG); Atrophic Gastritis (AG); Serological Biomarker Panel; GastroPanel; Non-Invasive; Helicobacter pylori; Pepsinogen I; Pepsinogen II; Gastrin-17; Pernicious Anemia; Parietal Cell Antibody

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Citation: Kari Syrjänen., et al. “Screening of the Patients with Autoimmune Thyroid Disease (AITD) and Type 1 Diabetes Mellitus (DM1) for Atrophic Gastritis (AG) by Serological Biomarker Testing (GastroPanel®)”. EC Gastroenterology and Digestive System 7.9 (2020): 181-195.

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